Women's Pain Is Different From Men's—the Drugs Could Be Too

Men and women can’t feel each other's pain. Literally. We have different biological pathways for chronic pain, which means pain-relieving drugs that work for one sex might fail in the other half of the population.

So why don’t we have pain medicines designed just for men or women? The reason is simple: Because no one has looked for them. Drug development begins with studies on rats and mice, and until three years ago, almost all that research used only male animals. As a result, women in particular may be left with unnecessary pain—but men might be too.

Now a study reveals differences in the sensory nerves that enter the spinal cords of men and women with neuropathic pain, which is persistent shooting or burning pain. The first such study in humans, it provides the most compelling evidence yet that we need different drugs for men and women.

"There’s a huge amount of suffering that’s happening that we could solve," says a professor of neuroscience, and an author. “As a field, it would be awesome to start having some success stories.”

Modern-day pain control is notoriously dismal. Our go-to medicines—opioids and anti-inflammatories—are just new versions of opium and  willow bark, substances we’ve used for thousands of years. Although they are remarkably effective in relieving the sudden pain of a broken bone or pulled tooth, they don’t work as well for people with persistent pain that lasts three months or longer.

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Sleep disturbance may be fatal for women with diabetes

Sleep disturbance in female diabetes patients can give way to elevated blood sugar levels, neuropathic pain and fatigue, a recent study has suggested.

In a study, conducted on 90 women with type 2 diabetes, these life threatening conditions were found even after controlling factors such as age, diabetes duration, depressive symptoms, and distress.

Senior author said, "Sleep disturbance in patients with diabetes is common and may negatively affect blood glucose".

The findings suggest that a comprehensive sleep evaluation for diabetes patients should also include tests on symptoms such as neuropathic pain and fatigue.

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"A thorough sleep assessment, especially in female adults, must include a symptom assessment. To do otherwise limits our ability to treat sleep disturbance effectively in this population", Dr. added.