Women's Pain Is Different From Men's—the Drugs Could Be Too
Men and women can’t feel each other's pain. Literally. We have different biological pathways for chronic pain, which means pain-relieving drugs that work for one sex might fail in the other half of the population.
So why don’t we have pain medicines designed just for men or women? The reason is simple: Because no one has looked for them. Drug development begins with studies on rats and mice, and until three years ago, almost all that research used only male animals. As a result, women in particular may be left with unnecessary pain—but men might be too.
So why don’t we have pain medicines designed just for men or women? The reason is simple: Because no one has looked for them. Drug development begins with studies on rats and mice, and until three years ago, almost all that research used only male animals. As a result, women in particular may be left with unnecessary pain—but men might be too.
Now a study
reveals differences in the sensory nerves that enter the spinal cords
of men and women with neuropathic pain, which is persistent shooting or
burning pain. The first such study in humans, it provides the most
compelling evidence yet that we need different drugs for men and women.
"There’s
a huge amount of suffering that’s happening that we could solve," says a professor of neuroscience,
and an author. “As a field, it would be awesome to start having some success stories.”
Modern-day pain control is notoriously dismal. Our go-to medicines—opioids and anti-inflammatories—are just new versions of opium and willow bark,
substances we’ve used for thousands of years. Although they are
remarkably effective in relieving the sudden pain of a broken bone or
pulled tooth, they don’t work as well for people with persistent pain
that lasts three months or longer.
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Labels: different, men's, neuropathic pain, pain, sensory nerves, women's
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