Coffee compounds may help to reduce prostate cancer risk
Scientists have identified kahweol
acetate and cafestol hydrocarbon compounds naturally found in Arabica
coffee which may inhibit the growth of prostate cancer.
The pilot study showed kahweol acetate and cafestol can inhibit growth in cells that are resistant to common anti-cancer drugs like Cabazitaxel.
“We found that kahweol acetate and cafestol inhibited the growth of cancer cells in mice, but the combination seemed to work synergistically, leading to a significantly slower tumour growth than in untreated mice,” said lead author.
For the study, presented at the European Association of Urology Congress in Barcelona, the team tested six compounds, naturally found in coffee, on proliferation of human prostate cancers cells in vitro (i.e. in a petri-dish).
They found cells treated with kahweol acetate and cafestol grew more slowly than controls. They then tested these compounds on prostate cancer cells, transplanted to mice (16 mice).
“After 11 days, the untreated tumours had grown by around three and a half times the original volume (342 per cent), whereas tumours in the mice treated with both compounds had grown by just over one and a half (167 per cent) times the original size,” he said.
It also showed the growth reduction occurred in transplanted tumour cells, rather than in native tumour cells.
Although “these are promising findings, but they should not make people change their coffee consumption,” cautioned Professor from the varsity.
“Coffee can have both positive and negative effects. We need to find out more about the mechanisms behind these findings before we can think about clinical applications. But if we can confirm these results, we may have candidates to treat drug-resistant prostate cancer,” he noted.
The pilot study showed kahweol acetate and cafestol can inhibit growth in cells that are resistant to common anti-cancer drugs like Cabazitaxel.
“We found that kahweol acetate and cafestol inhibited the growth of cancer cells in mice, but the combination seemed to work synergistically, leading to a significantly slower tumour growth than in untreated mice,” said lead author.
For the study, presented at the European Association of Urology Congress in Barcelona, the team tested six compounds, naturally found in coffee, on proliferation of human prostate cancers cells in vitro (i.e. in a petri-dish).
They found cells treated with kahweol acetate and cafestol grew more slowly than controls. They then tested these compounds on prostate cancer cells, transplanted to mice (16 mice).
“After 11 days, the untreated tumours had grown by around three and a half times the original volume (342 per cent), whereas tumours in the mice treated with both compounds had grown by just over one and a half (167 per cent) times the original size,” he said.
It also showed the growth reduction occurred in transplanted tumour cells, rather than in native tumour cells.
Although “these are promising findings, but they should not make people change their coffee consumption,” cautioned Professor from the varsity.
“Coffee can have both positive and negative effects. We need to find out more about the mechanisms behind these findings before we can think about clinical applications. But if we can confirm these results, we may have candidates to treat drug-resistant prostate cancer,” he noted.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE
HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
PS-
THOSE INTERESTED IN
RECIPES ARE FREE TO VIEW MY BLOG-
https://gseasyrecipes.blogspot.com/
FOR INFO ABOUT KNEE
REPLACEMENT, YOU CAN VIEW MY BLOG-
https:// kneereplacement-stickclub.blogspot.com/
FOR CROCHET DESIGNS https://gscrochetdesigns.blogspot.com
Labels: anti-cancer drugs, cafesol hydrocarbon, coffee compounds, growth of, inhibits, kahweol acetate, Prostate Cancer, resistant
posted by G S Iyer at 11:56 PM
0 Comments:
Post a Comment
<< Home