Saturday, November 24, 2018

Take Leave When You Have Flu

Biologists have detected what they say is the first evidence of changes in the social networks of ants through collective altered behaviour to protect their colonies from potentially deadly infections.

The scientists, who intentionally introduced a fungus in ant colonies grown in their laboratory, found that the fungus-contaminated ants and the uncontaminated ants stayed away from each other, displaying behavioural changes that protected vulnerable members of their colonies.

“The isolation of sick individuals had been observed earlier in ants and honeybees,” said  an evolutionary scientist and lead researcher.

“But this is the first time we’re seeing behaviour changes in contaminated and healthy ants affecting their colonies’ social networks.”

The findings point towards evolutionary mechanisms meant to prevent infections from spreading within colonies of social insects that are extremely vulnerable to infections because of their high population counts, frequent physical contact between individuals, and genetic similarities.

Researchers used an automated system to track the movements of thousands of black garden ants, maintained in 22 colonies, before and after exposing about 10 per cent of the worker ants to fungal spores.

They noticed changes in the ants’ behaviour even before the fungus-exposed ants had become sick. In the presence of the fungal spores, the ants changed how they interacted with each other -– the foragers and the nurses had fewer contacts with one another.

Using sensitive laboratory techniques, the scientists also found that this altered behaviour lowered the risk of the transfer of fungal spores from the infected ants to the others.

A few individuals received a high dose of the fungus but more ants received a low dose that, the scientists believe, could help bolster their immunity from future infections.

“The ants’ immune system can deal well with this lower pathogen level, which provides a form of immune memory,”  an evolutionary biologist said.

The biologist said the precise mechanisms through which the ants are able to detect the arrival of the fungus and subsequently alter their behaviour and social networking remain unclear.

“The detection itself may be through the sense of smell, which is very developed in ants,” the biologist said.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                             https:// kneereplacement-stickclub.blogspot.com/                                                                                       FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com

Labels: , , , , , , , , , , , ,

Monday, December 11, 2017

New drug could offer first treatment for irreversible Huntington's disease

The unstoppable progression of the inherited disease Huntington’s could be slowed or even halted by an experimental new treatment which has proved “enormously successful” in early patient trials.

A trial led by researchers  has demonstrated for the first time that a treatment is capable of suppressing the genetic defect which causes toxic proteins to build up in the brain.

Huntington's sufferers currently face the deterioration of their motor skills, memory and eventually death.

Patients ultimately die from complications including pneumonia and heart failure.

Currently treatments only exist for the symptoms of Huntington’s, which usually begin to appear between the ages of 30 and 50, leading to their gradual decline over the next 10 to 25 years.

Huntington’s sufferers carry a mutation in the Huntington gene, which results in the production of a toxic form of the Huntington protein that attacks the neurons making up the brain and nervous system.

The trial, involving 46 patients with the disease, saw a new experimental drug injected into the spinal fluid to silence the defective section of the genetic code which produces this toxic protein.

Patients were from different countries and roughly a quarter were given a placebo treatment.
 
The participants in the trial saw a drop in the levels of Huntington in the nervous system and, crucially, the drug appeared to be safe without harmful side-effects for patients.

Roughly 10,000 people in the UK have Huntington's, and around 25,000 people have inherited a gene that means they are at risk of developing it later in life.

The trial’s lead investigators, a professor of clinical neurology said: "The results of this trial are of ground-breaking importance for Huntington's disease patients and families.

“For the first time, a drug has lowered the level of the toxic disease-causing protein in the nervous system, and the drug was safe and well tolerated.

“The key now is to move quickly to a larger trial to test whether the drug slows disease progression".
 
“We are encouraged by the performance of IONIS-HTTRx in the clinical study,” said a Dr.

He added that the treatment “substantially exceeded our expectations and we were equally encouraged by the safety profile of the drug".

A Dr.  said: “This is a potential game-changer, not only for Huntington's disease patients but also for genomic medicine in general.

"Though more work needs to be done, if gene silencing lives up to this promise we could be on the brink of some of the personalised treatments that patients with severe genetic diseases need so badly.
"But this will also raise further questions for society and for policy-makers about how best to use such a powerful technique.”


THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.   

PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                      

HTTP:GSEASYRECIPES.BLOGSPOT.COM/
FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                       
HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/
FOR CROCHET DESIGNS

HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

Labels: , , , , , , , ,