Gallbladder gangrene reported in 5 patients who recovered from Covid; ‘first such case in India’, say doctors

Doctors at Sir Ganga Ram Hospital have seen five patients who developed gallbladder gangrene after recovering from Covid-19. Medical experts at the hospital believe this is the first report of such cases in India.

The five patients – four men and a woman aged between 37 and 75 – were successfully treated at the hospital between June and August. They complained of fever, pain in the right upper quadrant of abdomen, and vomiting. Two of them had diabetes and one suffered from heart disease. Three patients had received steroids for management of Covid-19 symptoms.

Dr Anil Arora, Chairman of the Institute of Liver, Gastroenterology and Pancreaticobiliary Sciences at the hospital, said, “We recently successfully treated five patients for gallbladder gangrene between June to August 2021, who had recovered from Covid-19 infection and presented with severe inflammation of gallbladder without gallstones (acalculous cholecystitis) resulting in gangrene of gallbladder requiring urgent surgery. To the best of our knowledge, this is the first report of a series of five cases from India in which gallbladder gangrene had occurred in patients after recovery from Covid-19 infection.”

The median duration between Covid-19 symptoms and diagnosis of “acalculous cholecystitis” was two months, and diagnosis was confirmed through ultrasound and CT scan of the abdomen.

Gallbladder stone disease is a very common problem in North India (affecting 8% of the general population) and is responsible for 90% cases of acute inflammation called cholecystitis. Only 10% of patients have “acalculous cholecystitis”, which is inflammation of gallbladder without evidence of gallstones or cystic duct obstruction.

All these patients successfully underwent laparoscopic removal of necrotic perforated gall bladders, Dr Arora said. He added that “acalculous cholecystitis” with gangrenous gallbladder is a serious condition associated with high morbidity (up to 30-60%) and much higher mortality than “calculous cholecystitis”.

It is usually seen in patients suffering from diabetes, HIV, vascular disease, total parenteral nutrition, those on prolonged fasting, in ICUs, and those with underlying history of trauma, burns and sepsis.

According to doctors, all five patients had recovered from Covid-19 and did not have the common and conventional predisposing factors mentioned above.

Dr Praveen Sharma, Senior Consultant, Gastroenterology Department, said: “Timely diagnosis and early intervention with broad spectrum antibiotics may prevent the development of onerous complication of gangrene and perforation of gallbladder.”

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Gangrene, hearing loss suggest Delta variant more severe, say doctors

Delta, the coronavirus variant that triggered India's devastating second wave of the pandemic, is definitely highly contagious, according to experts and multiple studies. Now, doctors in India draw from their experience that it is also possibly more severe than most other known variants. Blood clots and hearing impairment are just two of the many severe conditions Indian doctors have linked with the new strain.

: What is the Delta variant of COVID-19?

Delta or B.1.617.2 variant was first detected in India last year and has spread to 60 countries over the past six months. A recent study by an Indian government panel stated the variant was the "primary cause" behind India's deadly second wave and is 50% more infectious than a strain first identified in the UK. It is now sparking outbreaks in numerous other countries.

Conditions: Several patients developed blood clots, leading to gangrene

Some coronavirus patients in India developed micro thrombi - small but severe blood clots that caused the affected tissue to die and develop gangrene, said Ganesh Manudhane, a Mumbai-based cardiologist, according to Bloomberg. Manudhane treated eight such patients at the Seven Hills Hospital during the past two months, as compared to three or four cases throughout last year.

Fact: What is gangrene?

Gangrene is the death of body tissue due to a lack of blood flow or a bacterial infection. Signs and symptoms of the condition may include discoloration of the skin, swelling, and severe pain, among others. Treatments typically include surgery, antibiotics, and hyperbaric oxygen therapy.

Conditions: Hearing impairment, tonsillitis also seen in several patients

Meanwhile, some COVID-19 patients sought treatment for hearing loss, swelling around the neck, and severe tonsillitis, said Dr. Hetal Marfatia, an ENT surgeon at Mumbai's King Edward Memorial Hospital. "Every person is showing different symptoms" during the current wave, she was quoted as saying. Cases of Mucormycosis or "Black fungus" - a rare fungal infection - also reached record highs in India this year.

Vaccinations: How does it affect the course of vaccinations?

Emerging scientific evidence indicates that Delta and other variants may be able to evade antibodies generated from vaccination. Experts hence want pharmaceutical companies to tweak the formula for existing vaccines or develop new ones. "New vaccines have to prepared with new variants in mind," said Dr. Abdul Ghafur. "We can't get ahead of the virus, but at least we can keep up with it."

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Tragic pet owner dies after catching rare infection from his dog’s saliva that left him with gangrene and blisters

A PET owner has died after catching a rare infection from his dog's saliva which left him with gangrene and horrific blisters.

The 63-year-old, who has not been named, was completely healthy before being struck down with the devastating disease, doctors said.

The 63-year-old was completely healthy before being struck down with the devastating disease.

He spent more than two weeks suffering in hospital with a string of serious health conditions including pneumonia, gangrene and a fever of 41C.

The man was infected with Capnocytophaga canimorsus, a bacteria which is normally transmitted by bites - but can be spread through just a lick.

DEADLY INFECTION

When the man first went to hospital he had had flu-like symptoms for three days, a fever and had difficulty breathing.
His devastating story was reported in a medical journal by doctors from the Rote Kreuz Krankenhaus in Bremen, Germany.
Once medical treatment was underway, the man was already diagnosed with sepsis, and the man needed intensive care to try and save his life.
In the first four days while he was in hospital his condition got significantly worse, beginning with a rash on his face and nerve pain and bruises in his legs, reported recently.

What is Capnocytophaga canimorsus?

Capnocytophaga Canimorsus, a bacterial pathogen, is typically found in the saliva of cats and dogs.
It has the rare ability to cause disease in healthy individuals but has been known to cause severe illness in people with pre-existing conditions or compromised immune system.

The bacteria's transmission can occur through bites, licks or even close proximity to the animals.
Symptoms usually appear within one to eight days of exposure, but mostly on the second day. They can range from flu-like symptoms to sepsis.

Infection can usually be treated effectively with antibiotics and is recommended for a minimum of three weeks.

But there can be long-term side effects include amputation from gangrene, heart attack, and kidney failure.

The faster the infection is diagnosed the better the chance of survival. About 30 percent of all those infected die.

This then progressed to his kidneys and liver shutting down and blood clotting in his blood vessels, starting to rot his skin away.

These horrific effects then tragically led to a cardiac arrest.

The deadly infection he contracted is most often triggered by bites, according to doctors.

Medics were surprised it happened after licking alone, as the bug is rare and, according to one study in the Netherlands, affects only one in every 1.5million people. 

It is fatal in around 28 to 31 per cent of cases.

The man did not even have an open wound to begin with, which they said could have explained the more serious illness.

The team, led by Dr Naomi Mader, wrote: "Pet owners with flu-like symptoms should urgently seek medical advice when their symptoms exceed those of a simple viral infection, which in this case were (breathing problems and rash).

"Physicians confronted with such patients should ask about contact with dogs and cats."


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https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
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