Wednesday, January 15, 2020

AI can spot low-glucose levels without fingerprick test, finds study

Researchers have developed a new Artificial Intelligence (AI)-based technique that can detect low-sugar levels from raw ECG signals via wearable sensors without any fingerprint test.

Current methods to measure glucose requires needles and repeated fingerpicks over the day. Fingerpicks can often be painful, deterring patient compliance.

The new technique developed by researchers at University of Warwick works with an 82 per cent reliability, and could replace the need for invasive finger-prick testing with a needle, especially for kids who are afraid of those.

"Our innovation consisted in using AI for automatic detecting hypoglycaemia via few ECG beats. This is relevant because ECG can be detected in any circumstance, including sleeping," said Dr Leandro Pecchia from School of Engineering in a paper published in the Nature Springer journal Scientific Reports.


Two pilot studies with healthy volunteers found the average sensitivity and specificity approximately 82 per cent for hypoglycaemia detection.

"Fingerpicks are never pleasant and in some circumstances are particularly cumbersome. Taking fingerpick during the night certainly is unpleasant, especially for patients in paediatric age," said Pecchia.

The figure shows the output of the algorithms over the time: the green line represents normal glucose levels, while the red line represents the low glucose levels.

"Our approach enable personalised tuning of detection algorithms and emphasise how hypoglycaemic events affect ECG in individuals. Basing on this information, clinicians can adapt the therapy to each individual," the authors wrote.


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Wednesday, April 11, 2018

Novel skin patch can end painful, finger-prick blood tests in diabetic patients

Scientists have developed an adhesive patch, which can non-invasively monitor glucose levels in diabetics through the skin, potentially spelling an end for frequent painful finger-prick blood tests.

The patch does not pierce the skin, instead it draws glucose out from fluid between cells across hair follicles, which are individually accessed via an array of miniature sensors using a small electric current.

The glucose collects in tiny reservoirs and is measured, according to  a study published in the journal Nature Nanotechnology. Readings can be taken every 10 to 15 minutes over several hours.

Due to the design of the array of sensors and reservoirs, the patch does not require calibration with a blood sample - meaning that finger prick blood tests are unnecessary.

Researchers  hope that it can eventually become a low-cost, wearable sensor that sends regular, clinically relevant glucose measurements to the wearer's phone or smartwatch wire-lessly, alerting them when they may need to take action.

The advantage of this device is that each miniature sensor of the array can operate on a small area over an individual hair follicle - this significantly reduces inter- and intra-skin variability in glucose extraction and increases the accuracy of the measurements taken such that calibration via a blood sample is not required.

"A non-invasive - that is, needle-less - method to monitor blood sugar has proven a difficult goal to attain," said the researcher.

"The closest that has been achieved has required either at least a single-point calibration with a classic 'finger-stick', or the implantation of a pre-calibrated sensor via a single needle insertion," said the researcher.

"The monitor developed  promises a truly calibration-free approach, an essential contribution in the fight to combat the ever-increasing global incidence of diabetes," he said.

"We utilised graphene as one of the components as it brings important advantages: specifically, it is strong, conductive, flexible, and potentially low-cost and environmentally friendly," said a researcher.


"In addition, our design can be implemented using high-throughput fabrication techniques like screen printing, which we hope will ultimately support a disposable, widely affordable device," she said.

In this study the team tested the patch on both pig skin, where they showed it could accurately track glucose levels across the range seen in diabetic human patients, and on healthy human volunteers, where again the patch was able to track blood sugar variations throughout the day.

The next steps include further refinement of the design of the patch to optimise the number of sensors in the array, to demonstrate full functionality over a 24-hour wear period, and to undertake a number of key clinical trials.


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Scientists have developed an adhesive patch, which can non-invasively monitor glucose levels in diabetics through the skin, potentially spelling an end for frequent painful finger-prick blood tests.

The patch does not pierce the skin, instead it draws glucose out from fluid between cells across hair follicles, which are individually accessed via an array of miniature sensors using a small electric current.

Scientists have developed an adhesive patch, which can non-invasively monitor glucose levels in diabetics through the skin, potentially spelling an end for frequent painful finger-prick blood tests.

The patch does not pierce the skin, instead it draws glucose out from fluid between cells across hair follicles, which are individually accessed via an array of miniature sensors using a small electric current.

The glucose collects in tiny reservoirs and is measured, according to  ..

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