Endometriosis, ovarian cancer are genetically tied

A new research, led by the University of Queensland researchers, has demonstrated a link between endometriosis and ovarian cancer subtypes, enabling them to identify potential drug targets for therapy and increasing the understanding of both diseases.

The study was published in the journal, ‘Cell Reports Medicine’. Previous studies have shown that endometriosis sufferers have a slightly increased risk of developing epithelial ovarian cancer.

Dr Sally Mortlock and Professor Grant Montgomery from UQ’s Institute for Molecular Bioscience carried out a large genetic study to identify a genetic basis for this risk with a view to better understand the biological overlap between these reproductive disorders.

"More information about how they develop, their associated risk factors, and the pathways shared between endometriosis and different types of ovarian cancer have been needed," Dr Mortlock said.

Endometriosis is a chronic debilitating disease that affects the health of 1 in 9 women of reproductive age, where tissue similar to the uterus lining grows in other parts of the body, causing pain and infertility.

"Our research shows that individuals carrying certain genetic markers that predispose them to have endometriosis also have a higher risk of certain epithelial ovarian cancer subtypes, namely clear cell and endometriosis ovarian cancer," said Dr Mortlock.

She also said that although the diseases are genetically linked, the risk of ovarian cancer for those with endometriosis is not substantially increased.

"Overall, studies have estimated that 1 in 76 women are at risk of developing ovarian cancer in their lifetime and having endometriosis increases this slightly to 1 in 55, so the overall risk is still very low," she said.

The study found genes that could be drug targets to treat both endometriosis and epithelial ovarian cancer in the future.

"We explored specific areas of DNA that increase the risk of both diseases and identified genes in the ovary and uterus tissue that could be targeted for therapy and may be valuable to understand the link between the disorders and to disrupt biological pathways initiating cancer," Dr Mortlock added.

The researchers combined large datasets comparing the genomes of 15,000 people with endometriosis and 25,000 with ovarian cancer to find an overlap in risk factors between the two diseases.

 

 

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Home Treatments That Can Help Manage Ankylosing Spondylitis

Ankylosing spondylitis is a rare inflammatory condition that can be really difficult to live with, but you can help manage the symptoms of this debilitating disease with smart lifestyle choices, ranging from a specific exercise plan to more unusual treatments like acupuncture. This article focuses on these at-home treatments that will make life with this condition easier, can slow down the progression of the disease and prevent the development of dangerous complications.

What Are the Signs and Symptoms Of Ankylosing Spondylitis?

The symptoms of ankylosing spondylitis (AS) vary greatly, with some patients reporting back pain and stiffness in their late adolescence, and others starting to experience pain or immobility in other parts of the body as late as their mid-40s. Since the causes of the condition are still unknown, it is difficult to predict why people develop AS, but it is known that it may have a genetic component.

Also, men are more likely to suffer from AS than women, and in women, the condition more often manifests itself differently than in men, making diagnosis even more challenging. AS typically starts in the lower back, but it can affect most joints, such as:

• The joint between connecting the spine with the pelvis
• Vertebrae, especially the lower back
• Hips
• Shoulders
• Ribs and the breastbone.​

Despite the great variability, AS can be characterized by the following symptoms depending on the stage of the development of the disease:

• Back pain
• Stiffness
• Symptoms typically worsen during periods of inactivity, such as sleep or long periods of sitting
• Poor posture or stooped shoulders
• Pain and lack of flexibility in the feet
• Loss of appetite
• Low-grade fever
• Weight loss
• Fatigue
• Anemia or low iron.

If left untreated, the vertebrae in the lower back can fuse together, causing a characteristic tilt forward of the upper body. The complications of the disease include eye damage, problems breathing and even heart damage. Medical interventions and surgery are the traditional ways of managing the symptoms of AS, but doctors urge AS patients to stay active to slow the progression of the disease, as there is no cure for AS.

Below, we discuss natural treatments and why they are beneficial to AS patients.

Yoga and Stretching

Retaining your flexibility and range of motion is one of the main goals for an AS patient, as it helps your posture and reduces the pain. Yoga and stretching on a daily basis can make your spine and joints more flexible and improve your strength. 

Heat and cold therapy

Hot and cold temperatures are your friend if you’re experiencing stiffness or if your joints feel inflamed and painful. A warming shower or heating pads can decrease the pain and stiffness that come with AS, and ice packs may be helpful at reducing inflammation.

Exercise

Exercises that aim to stabilize and strengthen the joints are very beneficial to AS patients. These include range-of-motion exercises and strength training exercises. Strength exercises will also help you maintain a healthy weight, which is very important for AS patients.

Posture training

As we have discussed above, bad posture is one of the symptoms of AS, as the stiffness and the pain in the spine affect one’s posture. Practice good posture, give yourself reminders and be aware of how you carry your weight on a regular basis. You can also use special devices, such as chairs and seats that encourage good posture.

Therapeutic Massages

Therapeutic massages are beneficial for people suffering from AS, as they can help with the range of motion. Both relaxing and invigorating massages are beneficial, just make sure to mention to your massage therapist that you have AS, as deep tissue massage and joint massage is usually prohibited for patients with AS, and therapists use a specific kind of technique to relieve the pain and inflammation for this condition.

Acupuncture

This Ancient Chinese medicinal technique is known for stimulating specific points in the body, which triggers the release of pain-relieving hormones in the brain so this treatment can be beneficial for relieving pain for some AS patients. If you’re considering acupuncture to treat AS, look for a trained professional who works in a clean environment and uses sterile or disposable needles.

In summary, there are a variety of different home treatments of ankylosing spondylitis that will help people suffering from this condition maintain an active and fulfilling life, but each treatment should be discussed and supported by a medical professional for your safety.

See my next post for yoga poses for strengthening spine, thanks

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/    

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A New Way to Treat Vertigo

Do you suffer from chronic vertigo or dizziness? In severe cases, your doctor can prescribe you a medication, though this comes with a host of problems. Thankfully, there is a special treatment that you can try and it is free and safe enough to practice at home. 

 

Before we get into technique let's take a closer look at what vertigo is. Vertigo isn't just dizziness. It is a debilitating condition that can lead to life-threatening consequences, like higher risks of falls and car accidents. People who have experienced vertigo report that everything about them moves and spins. They will be unable to drive and walk and will have to hold onto a wall. It is a terrifying experience. 

Thankfully, otolaryngologist Dr. says that this special method will stamp vertigo right out when the patient starts to experience its first signs. But what causes vertigo? It usually stems from a complex inner ear issue where a build-up of particles start shifting upon movement, making the sufferer feel an intense spinning sensation. Recognizing this, Dr. realized that by using a twisting and turning motion she was able to release the built-up particles, alleviating the symptoms of dizziness. She then developed an exercise for her patients which anyone can do at home.

Here's How:
1. Get down on your knees and sit on the backs of your heels.
2. Tilt your head back with your eyes aimed at the ceiling. If your dizziness increases momentarily, don't worry.
3. While on your knees, put hands on the floor in front of you and let your head hang loose with your chin slightly tucked in.
4. Turn your head to either your right or left elbow depending on which ear you need to treat.
Bear in mind that it's important you achieve the right form.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                            PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/   

  FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                                https:// kneereplacement-stickclub.blogspot.com/                              

FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com