Friday, March 25, 2022

Some Basic facts about Cancer

Cancer is as old as mankind. It was found in the mummy of Egypt from 5000 years back. Unfortunately, even now, people are unaware about its nature, its cause, its prevention and most importantly there are several mis-concepts which make the problem even more complicated.


What is Cancer?
Body has the inherent capacity of repairing a dead or damaged tissue by multiplication of cells and there is a control system for this. When there is lack of control, the cells multiply excessively and form a lump. This is called tumour. This can be benign- where the lump is slow growing, does not cause damage to the neighbouring structure and do not spread to other organs and are usually not fatal. The other type of tumour is obviously malignant (cancer), where the lump grows very rapidly, involves the neighbouring and distant organs and can be fatal if not treated early.


What are the common types of Cancer?

In male, where tobacco addiction is a common problem, the common cancers are that of oral cavity, lung and prostate. In females, in rural population the common cancer is that of uterine cervix, whereas that of urban women is breast cancer.


What are the causes of Cancer?

Unfortunately, the causes in 2/3 of all cancers are still not clear, and several researches are going on worldwide to determine this. In 1/3, the causes are proved beyond doubt- of which the most important is tobacco in any form- smoking (Bidi, cigarette, hukka etc.) and smokeless (paan, paan masala, ghutka, khaini, jarda etc.). The other less common causative agents are diet (adulterated food, high fat and less of fruits, vegetables and vitamins, more intake of junk, fast, stored and charred food), sunlight (causes skin cancer especially in the white race), western lifestyle (lack of or delayed pregnancy and less breast feeding can cause breast cancer). For uterine cervical cancer the common causes are early and multiple children, multiple partners, low personal hygiene, infection by a virus (Human Papilloma Virus). In some cases (less than 5%), a genetic abnormality is found which can predispose to cancers in many members of the same family (mainly of breast, ovaries and bowel).


What are the symptoms of cancer?

Loss of appetite and body weight, an ulcer which is not healing, lump which is rapidly increasing, persistent change of voice, bleeding with cough, stool or urine, inte-rmenstrual bleeding, difficulty in swallowing etc.


Some common
misconceptions:
Cancer means death- Most cancers if detected early can be cured completely.


Cancer is contagious
– it is not


Biopsy can cause cancer or spread of cancer-
Biopsy or any surgery does not cause a benign tumour to turn cancerous. Taking a small sample of tissue (mostly done by Fine/ Wide bore Needle or a small punch forceps) do not cause any spread. The doctors can guide you regarding the best way of doing it. Biopsy is important before embarking on a major surgery, radiotherapy or chemotherapy as the tumour may actually be not malignant at all. Even if malignant, the treatment strategy is completely different in different kinds of cancer, so it is important to plan beforehand by knowing the nature of it.


Surgery in cancer causes spread of cancer- it is the reverse. The main treatment for most cancers in early stage is to remove the tumour along with some good healthy tissue margins and the neighbouring glands which may be involved. Removing a tumour partially is always bad and is never advisable. If the tumour is big and when complete surgical excision is not possible, chemotherapy (anti-cancer drugs) or radiotherapy is used to reduce the size and make it operable.


Cancer is hereditary- in 95% cases they are not. So there is no need to panic if only one member in the family had cancer, as it may be just accidental. However, if there are 2 or more members who are affected, it will definitely be advisable to see an Oncologist who can assess the risks and order relevant tests.


Chemotherapy is painful and causes severe vomiting and permanent hair-loss-
Although some strong chemotherapies which are administered in advanced diseases may cause vomiting, diarrhoea, low White Cell count and hence low Immunity etc., these can be counteracted by some preventive medications. Hair-loss is only temporary and does not occur with most of the chemotherapies.


Cancer can cause a very painful death- fortunately with different medicines which are now available and also with radiotherapy in some cases; pain can be very well controlled in advanced diseases where the patient cannot be cured. A new modality is Interventional pain therapy where the nerves conducting pain to the brain can be blocked by injection at specific sites.


There is no diagnostic or treatment facility in Eastern India- this is about time people of Eastern India realizes that there is no need to travel to far south or west or outside India for management of cancer. It is not only expensive to travel long distances, but causes unnecessary mental stress on the patient, when they prefer to stay in their locality and get maximum support from all the near and dear ones. There are enough facilities available in Eastern India for all classes of people. You may take help of different help lines, media and internet to find out which one suits you most.


Take home messages:
Cancer is preventable by avoiding the risk factors, and can be detected early if people come forward to the doctors with symptoms mentioned above without ignoring them. There is no need to think that one should not do tests as that may cause cancer or expose the fact that he or she is harbouring cancer. On the contrary, it is prudent to detect a cancer or a pre-cancerous area which can then be completely cured. The more it is neglected the worse is the result and more aggressive and expensive will be the treatment. Many organs like breast, limbs, larynx (voice-box) etc. can be preserved in early stages with the new modalities of treatment. It is not contagious, and hence it is important that the families give maximum support to the victims rather than staying away in fear.


Biopsies are advisable before embarking on a treatment and surgery is the treatment in most of the cancers in the early stage. There is no need to panic about radiotherapy and chemotherapy- in expert hands the side-effects are minimum and can improve the results significantly. Even in advanced stages symptom control can be well achieved with the Palliative care team and different Support groups. Together we must fight to remove all the misconceptions and try and prevent this potentially preventable and curable disease.


(The writer is Immediate Past President of IASO, Medical Director & Prof in Dept of Surgical Oncology, Saroj Gupta Cancer Centre & Research Institute, Thakurpukur, Kolkata)

 

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Monday, November 11, 2019

Pneumonia Epidemic World's Deadliest Child Killer

Pneumonia is the world's deadliest child killer, with a "forgotten epidemic" claiming one young life every 39 seconds, international health and children's agencies warned Tuesday.

The disease is preventable but still kills more children -- 800,000 under the age of five last year -- than any other infection, they said in a statement to mark World Pneumonia Day.

"Every day, nearly 2,200 children under the age of five die from pneumonia, a curable and mostly preventable disease," Henrietta Fore, Executive Director of UNICEF, said in a joint statement.

"Strong global commitment and increased investments are critical to the fight against this disease... Only through cost-effective protective, preventative and treatment interventions delivered to where children are will we be able to truly save millions of lives."

The numbers make grim reading and compare with 437,000 under-fives dying last year due to diarrhoea and 272,000 to malaria.

Five countries accounted for more than half of the child pneumonia deaths -- Nigeria with 162,000, India 127,000, Pakistan 58,000, the Democratic Republic of Congo 40,000 and Ethiopia 32,000.

Pneumonia is caused by bacteria, viruses or fungi, and leaves children fighting for breath as their lungs fill with pus and fluid.

Children with weakened immune systems and those living in areas with high levels of air pollution and unsafe water are most at risk.

The disease can be prevented with vaccines and is easily treated with low-cost antibiotics if properly diagnosed.

"This is a forgotten global epidemic that demands an urgent international response," said Kevin Watkins, chief executive of Save the Children UK.

"Millions of children are dying for want of vaccines, affordable antibiotics, and routine oxygen treatment. The pneumonia crisis is a symptom of neglect and indefensible inequalities in access to health care."

In January, the agencies will host world leaders in Spain at the first ever Global Forum on Childhood Pneumonia.

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Saturday, February 10, 2018

Doctors reveal new method to detect cancer cells at its most 'curable' stages

The cure for cancer has taken a giant step forward after the development of a project titled "CancerSEEK." The said project was developed by a medical team.

The principle behind the project is to detect cancer at its most curable stages. This detection is done through a unique blood test that is revealed to be capable of discovering up to eight diseases at once.
Particularly, these eight diseases are ovarian, esophageal, pancreatic, stomach, liver, breast, colorectal, and lung cancers. These were all in the report published in the journal.
 
The blood tests are unique due to its ability to detect mutated genes in the DNA of the person. The test checks the status of eight proteins along with the 16 genes in detecting cancer.

By detecting mutated genes early, researchers believe that they can formulate several strategies in combating and curing the cancer cells. So, while not exactly a quick cure for cancer, CancerSEEK prevents and cures it more efficiently compared to previous methods.

"This field of early detection is critical. I think this can have an enormous impact on cancer mortality. The earlier a cancer is found, the greater the chance of being able to treat it," said a cancer specialist.

CancerSEEK was tested on an estimate of 1,000 cancer patients. It is to be noted that the cancer patients who were tested were not in the grave stages where the cancer had already spread to other tissues.

According to the researchers' findings, 70 percent of the results were accurate, detecting cancer cells of all sorts from their list. Despite the high success rate, the team  has not released it publicly yet.

However, the research team gave an estimate of how much it could possibly cost, which is around $500 — cheaper or similar in price when compared with conventional methods for detecting cancer.

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