Scientists are hopeful that their discovery might be a breakthrough
in Alzheimer’s research, after experiments with oxytocin showed it might
be useful in treating, and maybe even reversing, degenerative
disorders.
The research, published on July 20, has revealed for the first time
that the chemical oxytocin, also known as the ‘cuddle hormone,’ could
have therapeutic benefits for cognitive disorders, including dementia.
Oxytocin is released by the pituitary gland and is known for its role
in the female reproductive system and in inducing feelings of love and
happiness. It can also can boost learning and memory, scientists found.
The study suggests that signals in the brain that become blocked, leading to dementia, may be able to be unblocked.
Alzheimer’s disease is a progressive disorder in which the nerve
cells, or neurons, in the brain and the connections among them
degenerate slowly, causing severe memory loss and deterioration in motor
skills and communication. One of the main causes is the accumulation of
a protein called amyloid beta (Aβ) in clusters around the brain
neurons, which hampers their activity and triggers their degeneration.
This deterioration affects a specific trait of the neurons, called
“synaptic plasticity”, which is the ability of synapses—where neurons
swap signals—to adapt to an increase or decrease in brain activity.
Synaptic plasticity is crucial to the development of learning and
cognitive functions in the hippocampus—the area of the brain where new
memories are formed and skills are learned.
Love is the drug
When oxytocin was added to the brains of mice, scientists found the
signaling abilities increased, which researchers say suggests that
oxytocin can reverse the impairment of synaptic plasticity caused by the
amyloid beta protein.
Scientists also artificially “blocked” oxytocin receptors in the
brain samples from mice to show that the hormone needs these receptors
to still be effective in boosting the synapses.
Researchers also found that oxytocin itself does not have any effect
on synaptic plasticity in the hippocampus, but it is somehow able to
reverse the ill-effects of amyloid beta.
Oxytocin is known to facilitate certain cellular chemical activities
that are important in strengthening neuronal signaling and formation of
memories.
Professor Akiyoshi Saitoh, who led a team of scientists from
Japan at the Tokyo University of Science, says, “This is the first study
in the world that has shown that oxytocin can reverse Aβ-induced
impairments in the mouse hippocampus.”
“Oxytocin was recently found to be involved in regulating learning
and memory performance, but so far, no previous study deals with the
effect of oxytocin on Aβ-induced cognitive impairment.”
This is only a first step and further research needs to be carried
out in living animals and then humans before sufficient knowledge can be
gathered to use oxytocin as a drug for Alzheimer’s, the team said.
But, Prof. Saitoh remains hopeful their new study could be the start of a breakthrough in the treatment of Alzheimer’s.
“At present, there are no sufficiently satisfactory drugs to treat
dementia, and new therapies with novel mechanisms of action are desired.
“Our study puts forth the interesting possibility that oxytocin could
be a novel therapeutic modality for the treatment of memory loss
associated with cognitive disorders such as Alzheimer’s disease.
“We expect that our findings will open up a new pathway to the
creation of new drugs for the treatment of dementia caused by
Alzheimer’s disease.”