Saturday, August 29, 2026

Science tells us what you should do right after getting up,, and how ti shapes your entire day

 In the first hour after you wake up, your brain is doing something remarkable. While you reach for your phone, pour coffee, or scan your inbox, it’s still coming out of its overnight cleaning cycle. 

The National Institute of Neurological Disorders and Stroke describes this process as flushing out metabolic waste and resetting neural pathways for the day ahead. What you do in that window doesn’t just start your morning; it shapes how those pathways perform for the next 16 hours. 

Your brain doesn’t switch on the moment you wake up, no matter how loud your alarm is. In the minutes after waking, thinking is slower, focus is foggy, and memory is still catching up, according to research

Grabbing your phone in that window may feel automatic, but it works against you. You’re handing your attention to other people’s priorities before your own mind is fully online. 

For founders acting as CEO, marketer, operator, and bookkeeper before 9 a.m., that’s not a small detail. It’s either a competitive edge or a missed one. 

What the science says about mornings 

Your brain runs on a 24-hour internal clock—the circadian rhythm—and that cycle governs far more than sleep. BMJ Mental Health research reveals that how you structure your day—wake time, light exposure, and nighttime screen use—directly impacts mood, focus, and decision-making the next day. 

The first hour after waking sets the tone. Neuroscience research from Tohoku University found that cognitive performance fluctuates by time of day, with mornings offering peak conditions for learning, adaptation, and connection-making. Cortisol naturally rises then, sharpening focus and mental clarity. 

This is your brain’s best window for deep thinking and important decisions. Spend it on email, and you’re handing your sharpest hour to someone else’s priorities. 

Consistency matters just as much. Research on morning routines shows that repeated habits can rewire the brain, shifting behavior from effortful control to automatic execution. 

The more consistent your morning routine, the less mental energy you burn and the more of your best thinking you save for work that moves things forward. 

The habits with the strongest science behind them 

Not all morning habits are equal. Research is clear on what actually moves the needle. 

  1. Get light fast. Within 30 minutes of waking, step into natural light. A Medical Hypotheses study found that daylight suppresses melatonin, triggers wakefulness, and resets your circadian clock. Five minutes outside or by a bright window is enough—high impact, low effort. 
  2. Move before you scroll. Even light exercise boosts cognitive performance, especially early in the day. That doesn’t require a full workout, just 10 minutes of walking, stretching, or yoga is enough to sharpen focus and support memory for hours. 
  3. Guard your first hour. Morning cortisol peaks make this your strongest window for deep work and decision making. Email, messages, and social media hijack that focus before you’ve used it for your own priorities. 

What this means for how you start your day 

You don’t need a complicated morning routine to see results. You need consistency. 

Choose one or two habits—light exposure, movement, or protecting your first hour—and do them in the same order every day. Consistency matters more than complexity. Over time, your brain automates the sequence, reducing decision fatigue and freeing up mental energy. 

That’s how you preserve your sharpest thinking for the work that matters most. 

Your morning isn’t just the start of your day. It’s the foundation for everything that follows. 


 

This is only for your information, kindly take the advice of your doctor for food, medicines, exercises and so on.   

 

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Thursday, January 02, 2020

Dengue virus becomes resistant to certain vaccines


While searching for a new approach in vaccine development for dengue, researchers discovered that the dengue virus changes its shape through mutations in envelope protein to evade vaccines and therapeutics.

DENV2 (a dengue virus) exists as smooth spherical surface particles while growing at the mosquito's physiological temperature (29 degrees Celsius). It then changes to bumpy surfaced particles at human physiological temperature (37 degrees Celsius).

This ability to morph helps the virus to evade the immune system of the human host. Hence, understanding the mechanism behind this is important for therapeutics and vaccine development, reported the study.

"Together with Professor Pei-Yong Shi from UTMB, we found that in laboratory-developed DENV2 strains, mutations in the virus' E protein causes its transformation into bumpy particles. These structural changes can cause vaccines and therapeutics to be ineffective against the virus," said Ms Xin-Ni Lim, the study's lead author who is from Duke-NUS' Emerging Infectious Diseases (EID) Programme.

The team also tested four DENV2 strains obtained from patients. They observed that in contrast to the laboratory-adapted viruses, the majority of these clinical strains maintained smooth surface structure at 37 degrees Celsius.

However, at 40 degrees Celsius, the temperature of a fever, all virus strains took on a bumpy surface.

"Our study gives a new direction to vaccine development and treatment for dengue disease. For prevention of disease through vaccines that are administered to the patient before dengue infection, we should use those that are effective against the smooth surface virus," said Dr Sheemei Lok, Professor, Duke-NUS' EID and corresponding author of this study.

"When it comes to patients displaying fever symptoms, treatment strategies effective against the bumpy surface particles should be implemented," added Dr Lok.

"This study is a first step towards gaining more insight into how DENV2 reacts and adapts to the host's immunological defences. We were also able to use computational modelling approaches to predict why particles from different DENV2 strains are more or less adept at morphing from the smooth to bumpy structures. By better understanding the interactions between the virus and the host, we will be able to develop better therapies and vaccines to treat or prevent infections, and contribute to public health outcomes," said Dr Peter Bond, Principal Investigator from A*STAR's BII.

The study's findings also show that the lab adapted DENV2 may not be a good model for research, as its structure is different from the clinical strains isolated from patients. The team is planning to study the other DENV serotypes to find out if there are any other possible structural changes.


this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
 




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Sunday, November 03, 2019

New Study Reveals Importance of Exercising Before Eating

It has long since been stated that the time at which you eat and exercise on a regular basis is of immense importance. Breakfast is also highly regarded as the most important meal of the day. While the normal assumption has been so far that exercise is better performed after consumption of food, food acting as a fuel for our bodies and breakfast being the foremost source of fuel, a recent study has found the opposite to be far more effective for staying healthy. 

One Study Among Many

Numerous studies have looked into the beneficial effects of exercising during periods of fasting. One particular study, dated as far back as 2010, looked into this very concept and successfully discovered the same. The effects of fasted training were found to be more potent than training that occurred after being fed. Facilitating the strength and adaptation of muscles to the training exercises in question increased glucose tolerance in the entire body. Insulin sensitivity was also improved in cases of consumption of high-calorie diets. 
 
However, the 2010 study  was conducted on healthy men, still leaving open a question regarding the effects of fasted training on those that are overweight or suffering from obesity. In fact, most studies in this line specifically studied the effects on lean or healthy persons. The study in question is therefore unique, as it followed the impact of the same on overweight and obese men in particular. 

A Different Approach

Aware of the results of fasting and feeding prior to exercise training on lean healthy men, this study is acknowledging that the precise physiological effects on people who are overweight or obese could be different on a structural level. Similar studies had been conducted in the past on obese and overweight women, but not on men in that category, keeping in mind that biological sex can also affect physiology. 

The study  was conducted by scientists from the University of Bath and the University of Birmingham, and divided into two sub-groups, acute and training groups. 

The acute group was to calculate the results in a preliminary manner, and the results of a single day test of exercise post and prior to eating breakfast for obese men. The training group was designed to check the long term effects of exercise prior to food consumption in obese men. The main purpose of approaching this study from this specific perspective was because of the effect that being sedentary and lethargic can have on muscle movement as well as insulin sensitivity. 

The Acute Study
The acute group consisted of 12 overweight and obese men from Birmingham who were given a standardized breakfast, usually consisting of cornflakes, skim milk, and toast with spread and jam. 

Their arrival and food consumption in the laboratory was monitored carefully, as was their meal consumption for the 48 hours prior to coming to the lab. This was to ensure that no meals were eaten in excess that could affect the outcome of the testing. 

After breakfast, a 90-minute rest was granted and then 60 minutes of cycling was carried out by the subjects. At each stage, samples of blood, muscle tissue and gas were collected from each subject and tested. 

The same test was also conducted in reverse on the 12 men, with breakfast being consumed immediately after the exercise was completed. It was found in this acute study, that the number of intramuscular lipids (a biochemical found in muscles which helps control insulin levels), was far greater utilized in those who exercised prior to breakfast.

The Training Study
The second test required 30 male participants from the region of Bath, UK. They were split into 3 groups; Group 1 was the no-exercise group, essentially maintaining the same routine as before.  Group 2 included those who exercised after consumption of breakfast,  and finally Group 3, who were required to exercise prior to breakfast. They were monitored for a period of 6 weeks to mark the results. 

It was first noted that group 3 burned double the amount of fat than the other exercise group. This is because overnight fasting improves insulin sensitivity, and lower insulin levels assist the body drastically in burning fat. While this burning of fat did not have a direct effect on weight loss, it improved the overall health of the participants in a number of ways. The tests revealed an increase in protein buildup in the body as well as a significant strengthening of the muscles. In fact, insulin levels appeared to remain stable for Group 3 even post-consumption of breakfast. 

Effect on Future Studies 

It was conclusively found in this study that exercising during fasting periods, essentially prior to the consumption of any major meal, as opposed to post-consumption (following a set period of rest time), was far more beneficial for the body, especially in the case of obese and overweight men. While the amount of weight lost and the fitness gained by control groups 2 and 3 were relatively the same, there was an increase in glucose-delivering proteins to the muscles that can help improve movement and lethargy.  In other words, exercising before breakfast burned more fat and made the muscles more efficient.
The study focused on the consumption of food high in carbohydrates, so future studies are aimed at looking at the possibilities in relation to low-carb meals, as well as the effects of the above tests on women because the current test was sex-specific. This study has paved the way for much future research into the benefits of fasted exercising, which has been revealed to be a viable method by which both healthy and obese men can improve their health. 

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
  
 
  

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