Breast Cancer Vaccine In Clinical Trials

Vaccines have saved humankind from a wide variety of life-threatening illnesses, some of which have been virtually eradicated thanks to widespread vaccine use. If a new clinical trial is any indication, the next disease we can cross off our list may be breast cancer, a disease which kills tens of thousands of women, and some men as well, every year.

The Mayo clinic has begun performing clinical trials with a potential vaccine for triple-negative breast cancer. For now, it’s being used on women who have survived early-stage breast cancer as a method of keeping the cancer from recurring.

Stacy Hanson has stage IV triple-negative breast cancer, so it is too late for the vaccine to do anything to help her. However, she is hoping the research can protect people like her young daughter, Lucy, who has likely inherited the gene mutation that significantly increased Hanson’s risk of the disease.

Hanson found out she had breast cancer just two years after Lucy was born, in her mid-forties. She beat the initial cancer, but then it came back as stage IV, and it’s now considered incurable. For a while, Hanson worried she wouldn’t live long enough to see her daughter start kindergarten.

Hanson inherited the mutated gene that likely caused her cancer from her father, but none of her siblings got it. Lucy is the only one in Hanson’s family, therefore, who likely has inherited the gene and is at an increased risk of developing breast cancer. The hope, of course, is that a vaccine will be available long before that risk goes into effect.
Yes, I hope that in my lifetime, science catches up and I get 40, 50 years,”  Hanson says, “I want that for myself. But more importantly, I want my daughter to have a life without cancer. I don’t want her to ever have to worry about cancer.”

 

The trial that may keep Lucy from getting cancer one day is still underway, and no conclusions can really be made at this point, but researchers are excited about the results they’re seeing so far.
Hanson hopes her story will encourage others fighting breast cancer to participate in research that could help keep people like her from developing cancer in the future.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

Radionuclide Therapy Could Be A Viable Treatment For Early-Stage Breast Cancer,

Researchers have identified another potential therapy for early-stage breast cancer.

Radionuclide therapy is a systemic (or whole-body) treatment that travels through the body via the bloodstream, like chemotherapy does. However, the radioactive substances in the treatment target  diseased cells in particular, so side effects are greatly reduced (unlike chemotherapy).

Roughly 20% of five-year breast cancer survivors will experience metastatic breast cancer sometime within five to ten years after treatment for the first occurrence of breast cancer. Metastatic breast cancer occurs when cancerous cells from the initial tumor break off and gain access to the circulatory system. From there, they can travel anywhere in the body. These cancerous cells are called  disseminated tumor cells (DTCs). DTCs may immediately develop into tumors elsewhere in the body, or they may stay dormant for several years before suddenly becoming active.

Researchers have found that radionuclide therapy can accurately target these DTCs and delay or stop their growth in early-stage breast cancer. Radionuclide therapy utilizes the alpha-particle-emitting radiopharmaceutical 223RaCl2 (Radium-233 dichloride). Not only can the treatment target DTCs, but it also is able to find and attack cancer cells that are outside of the immediate radiation field, called  bystander cells.

The study was published in the Journal of Nuclear Medicine. Researchers split female mice into three groups. First, each group was given either 0 kBq/kg (the control group), 50kBq/kg, or 600 kBq/kg of 223RaCl2 to create bystander conditions. Then, 24 hours later, the bone marrow of the mice were injected with human breast cancer cells that were either estrogen receptor-positive (ER+) or triple negative (which is not fueled by estrogen, progesterone, or HER2). The tumor cell count was measured on day one and then once a week after that to track growth.
Researchers found that DTCs were present in mice with both types of breast cancer. They found that mice with ER+ breast cancer had a 7-day growth delay in tumor progression when given 50 kBq/kg of 223RaCl2, and a 65-day growth delay when given 600 kBq/kg. The mice with triple negative breast cancer (TNBC) experienced a 10-day growth delay in tumor progression when given 600 kBq/kg. The mice with TNBC who were given 50 kBq/kg experienced no significant difference from the control group.

“The increased magnitude of the bystander effect in this study suggests that higher injected activities may better sterilize undetected dormant or slow-growing DTCs in the bone marrow micro-environment,” said researchers.
Because of these promising results, researchers say it may eventually be an option for certain patients who are in the early stages of breast cancer.

“This study adds to the mounting evidence that radiation-induced bystander effects can play a role in in the design of future treatment plans for radiopharmaceuticals alone or combined with external-beam therapy,” researchers said. “Furthermore, the capacity to target specific cells or tissues in a systemic manner may offer advantages over the use of external beams of radiation for eliciting therapeutic bystander responses.”

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

Aggressive breast cancers more likely to hit black and younger women

Younger women face elevated risks of developing breast cancers that are not only aggressive but also less responsive to treatment, a new study confirms. 

Researchers found that non-Hispanic black women were more than twice as likely as white women to be diagnosed with so-called triple-negative breast cancers, while women under 40 were nearly twice as likely to be diagnosed with the aggressive cancer as those aged 50 to 64, according to the study. 

In their analysis of more than one million cases of breast cancer between 2010 and 2014, the researchers also found that triple-negative cancers occurred more rarely than had previously been reported. 

The researchers did not respond to requests for comment but did supply a press statement. “We hope that this update on the epidemiology of triple-negative breast cancer can provide a basis to further explore contributing factors in future research,”  a researcher said in the statement. 

Noting that few previous studies had looked beyond the scope of a single state, researchers turned to the U.S. Cancer Statistics database, a population-based surveillance system of cancer registries with data that represents 99% of the U.S. population. The researchers identified 1.15 million cases of breast cancer between 2010 and 2014 in women from 39 states, including 96,749 cases (8.4%) of triple-negative cancer. 

Analyzing the data, the team found that non-Hispanic black women were 2.27 times more likely to be diagnosed with triple-negative breast cancer than non-Hispanic white women. Women under 40 were 1.95 times more likely than women aged 50 to 64 to be diagnosed with the aggressive cancer. 

The researchers also found that when women were diagnosed with a late stage cancer, it was more likely to be triple-negative.

The study confirms what cancer specialists have been seeing, said  a medical oncologist. Some of the increased risk in younger women can be tied to the BRCA1 gene, the Dr. said. “Besides BRCA1, we don’t have a clear cause for it in these women,” he added. 

Dr. was struck by the size of the study. “This is one of the larger, if not the largest, so far,” said a professor of medicine.

Another striking thing is triple-negative breast cancer was thought to be 15% of the total but this study found it was 8.4%.

That change could be due to a tightening of the definition of triple-negative breast cancer, the Dr. said. 

According to the U.S. National Cancer Institute, triple-negative breast cancer cells do not have estrogen receptors, progesterone receptors, or large amounts of a protein called HER2/.

While this study and earlier ones showed that triple-negative breast cancer is more common in women under 40, “I hear all the time from younger women that they were initially told by a doctor that they were too young to have breast cancer, said a Dr. “Most of them were symptomatic. They had lumps or discharge. A lot of times I see women who had lumps for 18 months before I saw them.” 

Since younger women aren’t screened regularly, the Dr. advises them to “be vigilant. Know your breasts and what is normal. Make sure you have a relationship with a provider who trusts you and who will work with you.” 

There’s a lot of misinformation out there about triple-negative breast cancer, the Dr. said. “The message on the internet is that this disease is like death sentence,” he said. “It has a higher mortality rate than other breast cancers, but 65% to 70% of people go on to be cured with conventional therapy.”

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                                                                                                     https://gscrochetdesigns.blogspot.com