Wednesday, December 18, 2019

What Every Woman Should Know About Her Thyroid Gland

Your heart and brain get all the attention, but your thyroid—that butterfly-shaped gland situated below your voice box and above your collarbone—is the true unsung hero of your body. It produces two main hormones, triiodothyronine (T3) and thyroxine (T4), that travel in your bloodstream, influencing physiological functions from head to toe. “Every cell in your body needs thyroid hormones to work correctly,” says a Dr. “They regulate everything from metabolism to bone health. So much depends on your thyroid being perfect.”

When it’s not, problems arise. If your thyroid gland is underactive, for example—a condition known as hypothyroidism  levels of T3 and T4 can sink too low; because the hormones influence neurological function, you might feel forgetful or depressed. If your thyroid is overactive, a condition called hyperthyroidism, T3 and T4 creep too high, and you may experience irritability or anxiousness, explains a Dr. Hyperthyroidism can also speed up your metabolism, and may lead to weight loss, while hypothyroidism can cause weight gain.

A thyroid dysfunction can throw off your menstrual cycle, too, and might explain peekaboo periods. Your thyroid even affects the regularity of your No. 2s: Hypothyroidism is linked to constipation, and hyperthyroidism can bring on frequent, loose BMs.

There’s a risk of more serious health issues as well. When thyroid hormones climb too high, the body destroys old bone faster than it can be replaced, which hastens osteoporosis. An overactive thyroid can also trigger the heart rhythm disorder atrial fibrillation. An underactive thyroid, on the other hand, can make you more prone to high cholesterol and complications with your blood pressure.
But the biggest tip-off that your thyroid isn’t functioning right is feeling “wiped,” says an endocrinologist. “You’re so tired that you’re not able to carry out your daily tasks or get through your normal workout routine.” And the tiredness doesn’t go away after a good night’s rest. That kind of overwhelming fatigue is a symptom of both hypo- and hyperthyroidism.

Risk Factors

Just being a woman raises your likelihood of developing a thyroid problem. Why that is remains somewhat of a mystery. “Estrogen definitely plays a role in some way,” says a Dr. “Thyroid cells have a lot of estrogen receptors,” he explains, which would make them especially sensitive to the effects of the female hormone.

There’s also the fact that many thyroid conditions are autoimmune disorders. The most common cause of an underactive thyroid, for example, is Hashimoto’s disease, while the most common cause of an overactive thyroid is Graves’ disease. And those are more likely to affect women too. Your genes may factor in as well: A 2017 study  found that almost half of Hashimoto’s patients have a family history of the disease.

The good news is, most thyroid disorders are treatable once you have a diagnosis. Your doctor can get a picture of what’s going on with an exam and a blood test that measures your level of TSH—or thyroid-stimulating hormone. This hormone is released by your pituitary gland to trigger the thyroid to produce T3 and T4.

In people with hypothyroidism, the thyroid gland doesn’t respond well to TSH, and the pituitary gland churns out more and more of the hormone in an effort to stimulate the release of T3 and T4. Conversely, when the thyroid is in overdrive, your brain senses that levels of T3 and T4 are too high, and the pituitary gland makes little to no TSH.

If your doc diagnoses you with hypothyroidism, she will prescribe a synthetic form of thyroid hormone called levothyroxine. This medication, which you take once a day, is considered very safe, says a Dr.  at the right dose, you should have minimal or no side effects.

With hyperthyroidism, the first line of treatment is usually the drug methimazole, which stops the thyroid from pumping out too much of the hormones, a Dr. says. But because there are some concerns with using antithyroid drugs during pregnancy, if you’re planning on having children at some point, you might consider having your thyroid removed instead, or taking radioactive iodine, which gradually shrinks the gland and ultimately destroys it. Once your thyroid is gone, you’ll need to take levothyroxine for life.

Stay Balanced

One thing you can do to help keep your thyroid healthy is make sure you have a good source of iodine in your diet. The mineral is a critical raw material for the production of T3 and T4. Most people consume enough iodine since it’s in fortified foods, such as breads, as well as iodized table salt—just ½ to ¾ of a teaspoon will get you to the daily target of 150 mcg. But if you are on a very-low-salt diet or only cook with sea salt, or you’re gluten-free, you might need to focus on other sources, says the Dr. Eggs, dairy, saltwater fish, and seaweed can all help you meet the requirement. People with hypo- or hyperthyroidism don’t need to consume more or less iodine than the recommended amount; there’s no evidence that the mineral can actually treat those conditions, and excessive amounts may worsen them.

If you suspect your thyroid needs a boost, you may be curious about the many “thyroid support” supplements sold in drugstores and online. These pills promise to increase your energy, rev your metabolism, and more. But they’re risky, warns a Dr.

When Mayo Clinic researchers analyzed 10 popular products, they discovered that nine of them actually contained T3 or T4, or both—and some of the supplements supplied doses that were equal to or higher than the amount of synthetic thyroid hormone a doctor might prescribe. Such a dose could cause serious side effects, including bone-mass loss or an irregular heartbeat.

Bring your thyroid concerns up with your doc before you experiment with an over-the-counter pill. She’ll help you identify the underlying problem, so you get a remedy that’s effective and safe. “Your thyroid is the engine that powers your entire body,” says a Dr. “With a little teamwork, you and your physician can make sure it’s right on track.”

Is thyroid cancer becoming more common?

In the past 30 years, diagnoses of thyroid cancer have tripled. But the spike isn’t as alarming as it sounds, says  a thyroid cancer surgeon.

Doctors are using ultrasound and other neck imaging more often, he explains: “Studies suggest much of the increase in diagnoses is due to incidental findings of small, slow-growing cancers that may not have been diagnosed in decades past.” In fact, he adds, there are many women walking around with such tumors who may never need treatment.

If your doc detects a nodule that’s less than a centimeter, she’ll likely track it to see if it’s growing, says an oncologist. (About 90 percent to 95 percent of nodules are benign.) With a larger cancerous nodule, depending on the size, the protocol is to have part or all of your thyroid surgically removed; after that, you’ll take a daily dose of the synthetic thyroid hormone replacement medication levothyroxine.


There’s unfortunately not much you can do to reduce your odds of thyroid cancer, says the Dr. “Over 95 percent of the time, there’s no associated risk factor—we just consider these cancers random genetic events.”
 this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

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Wednesday, July 10, 2019

Aggressive breast cancers more likely to hit black and younger women

Younger women face elevated risks of developing breast cancers that are not only aggressive but also less responsive to treatment, a new study confirms. 

Researchers found that non-Hispanic black women were more than twice as likely as white women to be diagnosed with so-called triple-negative breast cancers, while women under 40 were nearly twice as likely to be diagnosed with the aggressive cancer as those aged 50 to 64, according to the study. 

In their analysis of more than one million cases of breast cancer between 2010 and 2014, the researchers also found that triple-negative cancers occurred more rarely than had previously been reported. 

The researchers did not respond to requests for comment but did supply a press statement. “We hope that this update on the epidemiology of triple-negative breast cancer can provide a basis to further explore contributing factors in future research,”  a researcher said in the statement. 

Noting that few previous studies had looked beyond the scope of a single state, researchers turned to the U.S. Cancer Statistics database, a population-based surveillance system of cancer registries with data that represents 99% of the U.S. population. The researchers identified 1.15 million cases of breast cancer between 2010 and 2014 in women from 39 states, including 96,749 cases (8.4%) of triple-negative cancer. 

Analyzing the data, the team found that non-Hispanic black women were 2.27 times more likely to be diagnosed with triple-negative breast cancer than non-Hispanic white women. Women under 40 were 1.95 times more likely than women aged 50 to 64 to be diagnosed with the aggressive cancer. 

The researchers also found that when women were diagnosed with a late stage cancer, it was more likely to be triple-negative.

The study confirms what cancer specialists have been seeing, said  a medical oncologist. Some of the increased risk in younger women can be tied to the BRCA1 gene, the Dr. said. “Besides BRCA1, we don’t have a clear cause for it in these women,” he added. 

Dr. was struck by the size of the study. “This is one of the larger, if not the largest, so far,” said a professor of medicine.

Another striking thing is triple-negative breast cancer was thought to be 15% of the total but this study found it was 8.4%.

That change could be due to a tightening of the definition of triple-negative breast cancer, the Dr. said. 

According to the U.S. National Cancer Institute, triple-negative breast cancer cells do not have estrogen receptors, progesterone receptors, or large amounts of a protein called HER2/.

While this study and earlier ones showed that triple-negative breast cancer is more common in women under 40, “I hear all the time from younger women that they were initially told by a doctor that they were too young to have breast cancer, said a Dr. “Most of them were symptomatic. They had lumps or discharge. A lot of times I see women who had lumps for 18 months before I saw them.” 

Since younger women aren’t screened regularly, the Dr. advises them to “be vigilant. Know your breasts and what is normal. Make sure you have a relationship with a provider who trusts you and who will work with you.” 

There’s a lot of misinformation out there about triple-negative breast cancer, the Dr. said. “The message on the internet is that this disease is like death sentence,” he said. “It has a higher mortality rate than other breast cancers, but 65% to 70% of people go on to be cured with conventional therapy.”

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