When cancer spreads to the liver: Finding a way around this dangerous complication

One danger that all cancer patients face is liver metastasis. In laymen terms, this means that the cancer has spread to the liver. This is a dangerous complication and, most of the time, it is irreversible, and it significantly increases the mortality rate of cancer patients. However, researchers have been trying a way to overcome this complication by understanding the reason for poor prognosis and developing new treatment procedure. Now, a new study finds that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. But coupling immunotherapy with radiotherapy to the liver may restore the immune cell function and led to better outcomes. This has tremendous implications and may well pave the way for better treatment and prognosis for patients. The study is published in Nature Medicine.

Immunotherapy vs radiation therapy

According to researchers from University of Michigan Rogel Cancer Center, patients with liver metastases receive little benefit from immunotherapy, a treatment that has been a game-changer for many cancers. This research suggests that radiation therapy can reverse this resistance. This has potential to make a real difference in outcomes for these patients. A multidisciplinary team from the University looked at data from 718 patients who had received immunotherapy at the center. Patients had a variety of cancer types, including non-small cell lung cancer, melanoma, urothelial cancer and renal cell cancer, which had spread to different organs, including the liver and lungs.

Liver metastasis suppresses immune response

Repeatedly, those with liver metastases had worse responses to immunotherapy. The issue was not just in the liver either: these patients had more cancer throughout their bodies, compared to similar patients whose cancer had spread but not to the liver. The liver initiates a systemic immunosuppressive mechanism. The mechanism happens in the liver, but the entire body suffers the systemic impact.

The liver is one of the most common site to which cancer metastasizes. It’s known to interfere with immune response in autoimmune diseases, viral infections and organ transplants by suppressing certain critical immune cells. This plays out in metastatic cancer as oncologists observed a lack of immune response. Patients with liver metastases who received chemotherapy or targeted therapies did not have worse outcomes compared to those with other types of metastases. It’s unique to immunotherapy.

Tumous in liver siphon off the T cells

Looking within the microenvironment of the liver metastases, researchers saw that the tumors were siphoning off the T cells — immune cells that should have been working to attack the cancer. Not only were the T cells being eliminated in the liver, but this was also creating an immune desert throughout the body. As a result, the immune system could not be activated to fight tumors at any sites.

Activating the immune system with radiation therapy

Using mice with liver metastases, researchers delivered radiation therapy directly to the tumors in the liver. This stopped T cell death. With the T cells restored, an immune checkpoint inhibitor was then able to activate the immune system to eliminate the cancer throughout the body, on par with results seen in non-liver metastases.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

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7 Drinks to Clean Your Kidneys Naturally

Kidneys are small organs that play a vital role in keeping you healthy. They are part of your urinary tract and work to filter your blood. What they filter out is passed out as urine.
If you’ve ever had a kidney stone, you are well aware of your kidneys. Passing a stone has been likened to giving birth. It’s not fun!

Kidney infections are very dangerous. Kidney (renal) cancer causes about 14,000 deaths annually with 63,990 new cases diagnosed each year. Help keep kidneys operating happily and healthily by enjoying these drinks. In fact, one might be growing in your yard right this moment.
Number 5 is used for many cleanses and number 3 tastes like Christmas!

Dandelion Tea

Everyone knows the annoying dandelion, but did you know it is a healthy food source. The entire dandelion is edible and is particularly good for your kidneys. Dandelion tea is a good source of vitamins A, B-complex, C and D, iron, potassium, and zinc. It is a diuretic (make you urinate more) and replaces potassium lost in urine.
Dandelions are used in Native American medicines to treat kidney disease. It’s an anti-inflammatory and dissolves kidney stones. Check with a doctor first and use it only for a month at a time.

Beet Juice

Beet juice is a terrific kidney cleanser and will improve your liver health as well. Beet juice is full of anti-oxidants that remove free radicals and the beets increase urine acidity. This helps remove calcium decreasing the chance of developing kidney stones. Beets help cleanse your blood, supporting that part of the kidneys’ job.
A quick internet search yields many beet juice recipes, ranging from lemon/ginger/beet to a spicy basil/beet to watermelon and beet juices.
Ginger Tea
Ginger is one spice with a lot of health benefits. Research backs up the benefits of ginger. It removes free radicals and decreases inflammation associated with kidney disease.

Grate unpeeled washed ginger into hot water, cover it and allow it to step for 5 or more minutes. If you need a sweetener, add a touch of honey and enjoy. This tea will help a cough and sooth an upset stomach, including morning sickness. It may also lower cholesterol levels and fight infections.

Stinging nettle

Stinging nettle is a plant with a long history of uses in traditional herbal medicine. It is known to decrease inflammation and is high in anti-oxidants. Stinging nettle is approved for use in several European countries for treating kidney ailments. Because it is a diuretic, stinging nettle helps flush bacteria from the urinary tract. Drink an extra glass of water with each cup of tea to help the kidneys flush.
Stinging nettle can be an allergen and pregnant women shouldn’t drink stinging nettle.

Lemon juice
Most people have heard about lemon juice for fat flush and liver cleansing. Lemon and orange juice contain citrate that helps remove calcium from kidneys, thereby preventing the growth of kidney stones. Squeeze four or five lemons into a quart of cold water and drink.
Squeeze your juices from fruit because store brought varieties have a lot of added sugar and the pasteurization process breaks down nutrients.

Cranberry Juice

Cranberry juice is a popular and generally effective treatment for bladder infections. Since it gets filtered through the kidneys first, cranberry juice may help keep kidneys healthy. Bladder and urinary tract infections are unpleasant. Kidney infections that result from bacteria traveling from the urinary tract to the kidneys can be deadly. Cranberry juice can also prevent kidney stones.

Choose cranberry juice, not concentrate or cocktail. Straight cranberry juice can be a bit tart, so dilute with water.

Turmeric tea
Turmeric is another spice with amazing health properties. It is a powerful anti-inflammatory and known to stop inflammation associated with chronic kidney disease. Turmeric appears to stop leaky gut, also associated with chronic inflammation.

Turmeric lowers blood pressure, the second leading cause of kidney disease. Since it also improves liver function, drinking turmeric tea is a terrific kidney cleanse.

Turmeric Tea

Turmeric is another spice with amazing health properties. It is a powerful anti-inflammatory and known to stop inflammation associated with chronic kidney disease. Turmeric appears to stop leaky gut, also associated with chronic inflammation.

Turmeric lowers blood pressure, the second leading cause of kidney disease. Since it also improves liver function, drinking turmeric tea is a terrific kidney cleanser.

Add one teaspoon of ground turmeric to boiling water, simmer for 10 minutes. Add a bit of lemon juice and a pinch of black pepper.

To conclude
Every one of these natural kidney cleanses also come with other health benefits. You pretty much can’t go wrong! While you are enjoying these drinks, work on improving your lifestyle to further support your kidneys. Smoking and drinking alcohol and caffeine are hard on your kidneys. Control your blood pressure and blood sugar levels. Work to lower your cholesterol and lose weight as needed.

Kidneys are an important part of your body and they work hard. Support their efforts with these healthy drinks and you’ll hopefully avoid the pain of kidney stones and the agony of UTIs and kidney infections.

 this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
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Five Lesser Known Cancers That Every Man Should Be Aware About

The five widely ignored cancers among men are prostate, bladder, kidney, testicular and penis (penile) cancer. It is therefore important to be aware of the causes, symptoms and treatment for each of these for timely detection and treatment.

While prostate cancer is the most commonly spoken about, the others are equally significant.

Prostate Cancer

Prostate cancer occurs in the gland cells of the prostate, the gland surrounding the neck of the bladder. According to doctors, prostate cancer is the second leading cancer among males in India with the highest incidence among those who are more than 50 years of age.

Prostate cancer does not have significant symptoms initially but in the advanced stages, it can lead to obstruction in passage of urine and/or show blood in urine.

Common treatment methods include Radical Prostatectomy, Radical Radiotherapy, Hormonal Treatment or Chemotherapy.

Prostate cancer can be prevented by adopting lifestyle changes such as regular exercise, avoiding consumption of red meat, quitting smoking and consumption of alcohol and maintaining a healthy body weight.

Bladder Cancer

Bladder cancer occurs due to abnormal growth of the urinary bladder. While bladder cancer is primarily known to affect the elderly, there is a rising incidence among the younger population. Smoking is responsible for up to 66% of bladder cancers.

The most common symptoms are blood in urine, dark coloured urine, frequent urination or pain during urination. Please avoid smoking, drink enough fluids and eat a well-balanced diet.

Renal Cancer

Kidney cancer is a condition in which the kidney cells become malignant and form tumours.

Renal cancer is a condition in which the kidney cells become malignant and form tumours. It appears in the lining of tiny tubes inside the kidney.

While this disease has primarily affected the elderly over decades, there is a growing incidence among younger people.

Initial symptoms are blood in urine, persistent nagging pain or heaviness on the side of the back, unexplained fever, loss of appetite, anaemia, unexplained weight loss and swelling in ankles or legs.

Renal cancer can be prevented by eating a healthy diet, keeping blood pressure levels in control, exercising regularly and quitting smoking and consumption of alcohol.

Testicular Cancer

Testicular cancer is cancer of testicles, which are male reproductive organs. Testicular tumours are most common in young men aged between 15-34 years. The warning signs for this cancer include painless enlargement of the testes, heaviness of the scrotal sac and lumps in the testicles.

Testicular cancer is best treated through a multi-modality therapy including chemotherapy, surgery and radiotherapy.

Penile Cancer

Penile cancers develop in the penis. This is one of the few cancers, which can be prevented by maintaining good hygiene especially in the glans penis (bell end of the penis).

The incidence of penile cancer is more in developing countries such as India and it is more common in rural areas as compared to the urban population.

The cancer starts spreading from the foreskin or the glans penis. The early signs include red discoloration of the glans or foreskin, presence of painless or painful ulcers or any kind of abnormal growth.

 

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