A New Antibiotic Could Help Prevent Alzheimer’s, Parkinson’s

Researchers have found that antibiotic minocycline can increase the lifespan of aged roundworms by preventing the build-up of proteins, revealing a protective mechanism that could be used to help prevent age-related neurodegenerative diseases in humans.

Protein aggregation has been known to cause several progressive age-related brain diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's and prion disease.

The study, led by a team from the Scripps Research in the US, showed that minocycline prevents this build-up even in older animals with age-impaired stress-response pathways.

The number of proteins in a cell is balanced by the rate of protein manufacture and disposal, called proteostasis. As we age, proteostasis becomes impaired.

For the study, the team first tested 21 different molecules known to extend lifespan in young and old Caenorhabditis elegans (C. elegans) worms.

They found that all of these molecules prolonged the lives of young worms; however, the only drug that worked on older worms was minocycline.

To find out why, they treated young and old worms with either water or minocycline and then measured two proteins called a-synuclein and amyloid-ß -- known to build up in Parkinson's and Alzheimer's diseases, respectively.

It is because minocycline directly affects the protein-manufacturing machinery of the cell, known as the ribosome. This was true in worms as well as in mouse and human cells, the researchers said.

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Mediterranean Diet, Exercise Can Cut Risk Of Alzheimer's

Mediterranean diet, regular physical activity and a normal body mass index can reduce the incidence of protein build-ups that are associated with the onset of Alzheimer's disease, says a study.

The findings showed that each one of several lifestyle factors - a healthy body mass index, physical activity and a Mediterranean diet - were linked to lower levels of plaques and tangles on the brain scans. Plaque, deposits of a toxic protein called beta-amyloid in the spaces between nerve cells in the brain; and tangles, knotted threads of the tau protein found within brain cells, are considered the key indicators of Alzheimer's.

The Mediterranean diet is rich in fruits, vegetables, legumes, cereals and fish and low in meat and dairy, and characterised by a high ratio of monounsaturated to saturated fats, and mild to moderate alcohol consumption.

Earlier studies have linked a healthy lifestyle to delays in the onset of Alzheimer's disease.

However, the new study is the first to demonstrate how lifestyle factors directly influence abnormal proteins in people with subtle memory loss who have not yet been diagnosed with dementia, the researchers said. "The study reinforces the importance of living a healthy life to prevent Alzheimer's, even before the development of clinically significant dementia," said lead author David Merrill, Psychiatrist at the University of California, Los Angeles.

Healthy lifestyle factors have also been shown to be related to reduced shrinking of the brain and lower rates of atrophy in people with Alzheimer's.

Older age is the leading non-modifiable risk factor for Alzheimer's disease.

"The fact that we could detect this influence of lifestyle at a molecular level before the beginning of serious memory problems surprised us," Merrill added.

In the study, 44 adults ranging in age from 40 to 85 with mild memory changes but no dementia underwent an experimental type of positron emission tomography (PET) scan to measure the level of plaque and tangles in the brain.

Researchers also collected information on participants' body mass index, levels of physical activity, diet and other lifestyle factors.
"The work lends key insight not only into the ability of patients to prevent Alzheimer's disease, but also physicians' ability to detect and image these changes," Merrill noted in the paper appearing in the American Journal of Geriatric Psychiatry.

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