Wednesday, March 16, 2022

USC experts discover brain differences in young children with binge eating disorder

Brain scans of children ages 9-10 with a type of eating disorder that causes uncontrollable overeating showed differences in gray matter density compared to their unaffected peers, according to a USC-led study.

Binge eating disorder, which affects about 3-5% of the U.S. population, is characterized by frequent episodes of eating large amounts of food and a sense of having no control over the behavior. The study’s findings suggest that abnormal development in the brain’s centers for reward and inhibition may play a role.

“In children with binge eating disorder, we see abnormality in brain development in brain regions specifically linked to reward and impulsivity, or the ability to inhibit reward,” said lead author Stuart Murray, Della Martin Associate Professor of Psychiatry and the Behavioral Sciences at the Keck School of Medicine of USC, where he serves as director of the Eating Disorders Program.

“These kids have a very, very heightened reward sensitivity, especially toward calorically dense, high-sugar foods. The findings underscore the fact that this is not a lack of discipline for these kids.”

Pandemic saw increase in eating disorders among young people.
Experts say eating disorders in young people soared during the pandemic, along with steep increases in hospitalizations. Social isolation, stress, disruption of routine and a social media-fueled quest for perfection all exacerbated disorders such as anorexia, muscle dysmorphia and binge eating.

Binge eating disorder puts people at risk for obesity, metabolic syndrome, abnormal cardiac function and suicidal thoughts. Treatment goals include reducing the frequency of binge eating episodes by removing “trigger” foods, as well as addressing underlying anxiety or depression. Treatment with medication and talk therapy is effective about only half the time, Murray said.

For this study, Murray and his colleagues analyzed brain scans and other data from 71 children with diagnosed binge eating disorder and 74 children without binge eating disorder, who are part of a large longitudinal study called the Adolescent Brain and Cognitive Development Study. That study includes data of 11,875 children ages 9-10 who were enrolled in 2016-2018 and recruited from 21 sites around the U.S.

In the children with binge eating disorder, they saw elevations in gray matter density in areas that are typically “pruned” during healthy brain development. Synaptic pruning, a development phase that occurs between ages 2 and 10, eliminates synapses that are no longer used, making the brain more efficient. Disturbed synaptic pruning is linked to a number of psychiatric disorders.

“This study suggests to me that binge eating disorder is wired in the brain, even from a very, very early age,” Murray said. “The question that we don’t know, which is something that we will address in time, is whether successful treatment of binge eating disorder in kids helps correct brain development. The prognosis of almost all psychiatric diseases is better if you can treat them in childhood.”
 

 

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Saturday, June 22, 2019

Adolescents exercising to gain weight are prone to disordered eating

Maintaining health is a good habit. But a new study has pointed out that some adolescents who indulge in exercises to gain weight are prone to so-called muscularity-oriented disordered eating behaviours.

The findings published stated that 22 % of males and 5 % of females aged 18-24 exhibit these disordered eating behaviours.

These disorders are defined as including at least one of the following eating more or differently to gain weight or bulk up, and use of dietary supplements or anabolic steroids to achieve the same goal.
If neglected or left unchecked, these behaviours y  escalate to muscle dysmorphia, characterized by rigid diet, obsessive over-exercising and extreme preoccupation with the physique.

Unlike anorexia nervosa, which may be easily identified by parents or paediatricians, disordered eating to increase bulk may masquerade as healthy habits and because of this, it tends to go unnoticed, said the 1st author of the study.

He also added that at its most extreme, it can lead to heart failure due to insufficient calories and overexertion, as well as muscle dysmorphia, which is associated with social withdrawal and depression.

The study incorporated 14,891 young adults from U.S., who were followed for 7 years. The researchers wanted to see if the early data, when the participants' average age was 15, revealed something about their perceptions and habits that may serve as warning signs.

they found that boys who exercised specifically to gain weight had 142 % higher odds of this type of disordered eating. In girls, the odds were increased by 248%.

On the other hand, boys who perceived themselves as being underweight had 56% odds, in girls, the odds were 271 % higher.

Additionally, being of black race bolstered odds by 66% in boys and 191% in girls.

In young adulthood, 6.9% of males reported supplement use to gain weight or build muscle and 2.8% said they used anabolic steroids. While supplement use in young women was significantly lower at 0.7% and 0.4% respectively.

Supplements can cause liver and kidney damage. Anabolic steroids can cause both long-term and short-term health issues, including shrunken testicles, stunted growth and heart disease, he noted.

He also pointed out some clues that indicate hinting at muscle dysmorphia include a highly restrictive diet that omits fats and carbohydrates, compulsive weighing and checking of appearance, and extensive time dedicated to exercise that may cut into social activities.

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