Human Stem Cells May Help Boost Diabetes Treatment:- Foods That Can Help Manage Diabetes

Human stem cells could hold the ability to produce insulin-producing cells that in the future can be transplanted into diabetes patients. According to a latest study, this path-breaking discovery may prove to be a useful intervention in the ongoing diabetes treatment studies across the globe.

The study published in the journal Nature Cell Biology stated, that about 415 million people have been diagnosed with diabetes globally. Most of these people lack the ability to produce sufficient amounts of insulin, which regulates the blood sugar in the body. This lack of insulin production can bring about a  host of health consequences in the body and even prove to be fatal.

The findings revealed that regulation of cell polarity is the key to the development of many other human cell types, for instance the nerve cells as well for transmitting signals in neurons. The cell polarity is the asymmetric organisation of several cellular components, including its plasma membrane, cytoskeleton or organelles.

For the study, the team studies how the body creates the complex piping systems that transport fluids and gases in our organs to understand the machinery for initiating progenitor cells into their different paths. 

"By identifying the signals that instruct mouse progenitor cells to become cells that make tubes and later insulin-producing beta cells, we can transfer this knowledge to human stem cells to more robustly make beta cells," said a Professor.

The study further noted that the same signal -- the so-called epidermal growth factor (EGF) pathway -- controls both the formation of pipes and beta cells through polarity changes.

"Therefore, the development of pancreatic progenitor into beta cells depends on their orientation in the pipes," the researchers explained on the basis of the study conducted over mice.

"Now we can use this knowledge to more efficiently turn human stem cells into beta cells in the laboratory with the hope to use them to replace lost beta cells in patients suffering from diabetes," the Prof. stated.

If you already happen to suffer from diabetes, keep the following diet-related points in mind for better health:

1. Fenugreek/ Methi- Fenugreek is excellent for maintaining blood sugar levels. Include fenugreek seeds and leaves in your diet. Fenugreek water can be included in your diet while soaked and sprouted fenugreek seeds also work wonder in managing diabetes.

2. Indian gooseberry /Amla juice - Amla Juice when consumed the first thing in the morning, can go a long way in helping you manage diabetes better. Add a pinch of turmeric for better results. Bitter gourd juice and aloe vera juice can also become a regular part of your diet.

3. Beetroot-  Beetroots are a rich source of vitamins, minerals, fiber, and phytonutrients - all of which help in managing diabetes. When consumed the natural sugars in beetroot don't get converted into glucose in the body too quickly which makes them good for diabetics. Beetroots are also high in a type of antioxidant called lipoic acid which protects your cells from the damage caused by aging.

4. Tomatoes- Rich in lycopene, tomatoes are great for your heart. They also reduce blood pressure and the risk of heart complications associated with diabetes. Tomatoes are packed with Vitamin C, Vitamin A and potassium. They are low-carb and also low in calories which make them a superfood for diabetics.

5. Pumpkin Seeds- Keep a handful of pumpkin seeds with you to fight cravings for fatty and sugary foods. They are rich in iron and unsaturated fats and help in suppressing your appetite. When it comes to snacking, always remember that the key is portion control.
 
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES. PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                      

HTTP:GSEASYRECIPES.BLOGSPOT.COM/
FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                       

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/
FOR CROCHET DESIGNS
HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

Type 2 diabetes drug can exhaust insulin-producing cells, claims new study

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOUR PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.

PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-
HTTP:GSEASYRECIPES.BLOGSPOT.COM      

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/

FOR CROCHET DESIGNS- http://My Crochet Creations.blogspot.com/


Long-term use of liraglutide - a drug used to lower blood sugar levels in type 2 diabetes patients - may have a deteriorating effect on insulin-producing beta cells, leading to an increase in blood sugar levels, a new study has claimed.

There is now compelling evidence that liraglutide therapy is efficacious at least in the short term, since it produces an initial reduction in blood sugar. However, many patients do not respond to the treatment and some even display adverse reactions such as nausea, vomiting and diarrhoea.

Researchers from Karolinska Institute in Sweden and University of Miami in US conducted a study on mice implanted with human insulin-producing cells. Blood-sugar suppressors in the form of analogues of the incretin hormone GLP-1 are commonly used in the treatment of type 2 diabetes, since they stimulate the glucose response of the pancreatic beta cells to make them secrete more insulin.

To study the long-term effects of incretin therapy, researchers worked with humanised mice, generated by transplanting human insulin-producing cells into the anterior chamber of the eye. The mice were given daily doses of liraglutide for more than 250 days, during which time the researchers were able to monitor how the pancreatic beta cells were affected.

The results showed an initial improvement in the insulin-producing cells, followed by a gradual exhaustion, with reduced secretion of insulin as a response to glucose. This, they say, was unexpected.

"Given the lack of clinical studies on the long-term effect of these drugs in diabetes patients, this is a very important discovery," said Midhat Abdulreda from University of Miami. "We also need to take these results into account before prescribing blood-sugar suppressing GLP-1 analogues when planning long-term treatment regimens for patients," said Per-Olof Berggren from Karolinska Institute.

"Our study also shows in general how to carry out in vivo studies of the long-term effects of drugs on human insulin-producing cells, which should be extremely important to the drug industry," said Berggren.

The findings were published in the journal Cell Metabolism.