Sunday, March 01, 2020

Transcendental meditation correlated with specific changes in the brain

A new study conducted at IMT School for Advanced Studies Lucca shows that the subjective feeling of well-being experienced by many people with the practice of meditation is correlated with specific changes in the brain.

The research, which appeared in Brain and Cognition, examined the effects of the technique known as Transcendental Meditation (TM), which consists in the silent repetition of a meaningless sound, a "mantra".

For the study, conducted at the Molecular Mind Laboratory (MoMiLab) of IMT School for Advanced Studies Lucca, the researchers enrolled 34 healthy young volunteers and divided them in two groups. The first one practiced Transcendental Meditation 40 minutes per day in two sessions of 20 minutes each, one in the morning and the other in the evening; the second group did not change its daily routine.

At the beginning of the study, the researchers also measured through psychometric questionnaires the anxiety and stress level of all the participants, as well as their ability to manage stressful situations. Each individual was also subjected to a functional magnetic resonance imaging test (fMRI), in order to measure brain activity at rest and changes in the functional connectivity among different cerebral areas. After three months, at the end of the study, the same tests were repeated.

The analysis of the data clearly showed that levels of anxiety and stress perceived by the subjects who followed the meditation program were significantly reduced in comparison with those of the volunteers who did not practice TM.

Magnetic resonance imaging also shows that the reduction of anxiety levels is associated with specific changes in the connectivity between different cerebral areas, such as precuneus, left parietal lobe and insula, which all have an important role in the modulation of emotions and inner states. In the control group, instead, none of these changes was observed".    Giulia Avvenuti, Ph.D. fellow at IMT School and first author of the study.


"The fact that Transcendental Meditation has measurable effects on the 'dialogue' between brain structures involved in the modulation of affective states opens new perspectives for the understanding of brain-mind relationships" says Pietro Pietrini, IMT School's Director and coordinator of the study. "It also extends the results of recent research suggesting that drugs therapies and psychotherapy leverage on the same biological mechanism".

Transcendental Meditation has recently gained an increasing success worldwide as a relaxation practice also thanks to the David Lynch Foundation, which co-financed the study along with the Fondazione Cassa di Risparmio di Lucca. Founded in 2005 by the movie director David Lynch, who is himself a longtime practitioner and supporter of the social value of Transcendental Meditation, the David Lynch Foundation promotes TM practice as an approach to reduce stress in schools (as for the 'Quiet Time-Meditate Lucca' project at the Pertini High School) and workplaces, and to build resilience in victims of trauma.

"I am very happy of the results of this study that used the latest technology to show the beautiful benefits for the human beings of TM. Now I'm working to form my foundation also in Italy, with teachers who teach transcendental meditation in schools, work places and other groups, reaching as many people as possible" says David Lynch.

This new study, coherently with previous ones, shows that even a few months of practice of Transcendental Meditation have positive effects on psychological well-being and that these effects are correlated with measurable changes in the brain.


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

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Friday, March 15, 2019

The Surprising Link Between Sleep and Pain Sensitivity

The correlation between sleep deprivation and a heightened sensitivity to pain is not an apparent one, but it may exist. In a 2018 paper, researchers established that our brains may turn off their “pain-protection” gear on days we don’t sleep enough.

Now let’s delve a little deeper into the findings of this paper and try to understand what makes us so irritable and grumpy when we sleep too little.
 
The Experiment To examine the connection between pain and no sleep, the researchers conducted an experiment using functional magnetic-resonance imaging (FMRI), during which a number of participants’ brain activity was recorded as they were exposed to a growing heat on one of their legs.
Once the patient noted the heat becoming unbearable this point was established as the pain threshold and the experimenters stopped recording brain activity.
Findings
1. How Did Participants React to Pain?  The findings surprised even the researchers themselves. Despite the small sample size (25 participants), the experimenters managed to establish that the threshold for thermal pain among the well-rested individuals was 111°F (44°C), whereas the sleep-deprived group could handle 4 degrees less.
2. What Brain Regions Could Account for The Different Pain Sensitivity? 
 
The region of the brain responsible for the perception of pain, the primary somatosensory cortex (highlighted in orange in the picture below), was significantly more responsive in the sleep-deprived individuals.
pain and sleep primary somatosensory cortex
The most interesting and surprising finding, however, was related to other parts of the brain, the striatum and the insula (schematically highlighted below in purple).
These regions are responsible for producing a hormone linked to pain tolerance, among other things, dopamine. The brains of the people who didn’t get enough sleep produced significantly less dopamine, which made them worse at tolerating painful stimuli than the control group.
Finally, the researchers conclude that the effect of sleep deprivation can last for several days, with the individuals who got less sleep continuing to be more sensitive to pain days after getting little sleep.
 
striatum and insula

3. What Conclusions Can We Make From This Study?

  • These findings opened our eyes to the problem of sleep deprivation-induced pain sensitivity. This is particularly important hospital patients, who can be experiencing more pain because of the noisy hospital rooms in which they have to stay.
  • The data can also be relevant to people suffering from painful chronic conditions, as a quality sleep could decrease their pain sensitivity.
  • Finally, it is yet to be discovered if the same pain and no sleep link can be extended to the psychological experiences we have when we don’t get enough sleep: irritability and nervousness.
What remains really clear, however, is that scientists found yet another reason for us to get a good night’s sleep every night. 

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