Probiotics prevent deadly complications of liver disease: Study

Probiotics are effective in preventing hepatic encephalopathy in patients with cirrhosis of the liver, according to a study by the Govind Ballabh Pant Hospital, New Delhi.


Hepatic encephalopathy is the deterioration of brain function - a serious complication of liver disease.
The research shows that probiotics modify the gut microbiota to prevent hepatic encephalopathy.
According to experts, the results offer a safe, well tolerated and a cheaper alternative to current treatments.

The researchers at G.B. Pant conducted a single-centre, randomised trial with cirrhosis patients who showed risk factors for hepatic encephalopathy, but had yet to experience an obvious episode.
When comparing treatment with probiotics versus placebo, the researchers found that the incidence of hepatic encephalopathy was lower in patients treated with probiotics.

Probiotic supplementation was not associated with any side effects and none of the patients required discontinuation of therapy.

“These results suggest that probiotics are similar in effectiveness to the current standard of care, lactulose, in the prevention of hepatic encephalopathy, yet they appear to be much better tolerated,” researchers added.

Up to 45 percent of patients with cirrhosis develop hepatic encephalopathy, a loss of brain function that occurs when the liver is unable to remove toxins from the blood.

Prognosis is poor, with a 58 percent mortality rate at one year, and a 77 percent mortality rate at three years.

"These results offer a safe, well tolerated and perhaps cheaper alternative to current treatments," said David W. Victor III, who contributed an editorial in the journal Clinical Gastroenterology and Hepatology on this research.

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Links between alcoholic liver disease and circadian clock revealed!

Researchers have revealed a putative role for the circadian clock in the liver in the development of alcohol-induced hepatic steatosis, or fatty liver disease.

The team from the University of Notre Dame and the Indiana University School of Medicine has shown that the development of liver steatosis produced by alcohol abuse is intertwined with disturbances of the normal operation of the 24-hour clock system located in the cells of the liver.

The study has suggested that either the circadian clock is important in the actual development of the liver disease or that the development of steatosis disrupts the normal pattern of the clock mechanism.

The researchers said that the mechanism by which chronic alcohol intake is thought to alter the control of fat metabolism in the liver is also a shared signal to the circadian clock mechanism, this being the ratio of production of reduced nicotinamide adenine dinucleotide, and may be a key to the shared disturbance to the two biological mechanisms of lipid metabolism and the circadian clock.

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