Tuesday, September 07, 2021

Here’s Where Our Minds Sharpen in Old Age

Many have noted that the big contenders in the last two American presidential elections were well into their 70s, raising questions of the mental capacity, going forward, of these potential leaders. “Starting after middle age, say around 60 or so, memory and other abilities decline,” says Dilip Jeste, professor of psychiatry and neuroscience at UC San Diego and director of the UCSD Center for Healthy Aging. But what actually declines—and what abilities might improve, as well as when, how, and at what speed—is a complex issue. 

It turns out, according to a new study in Nature Human Behavior, that many things improve with age, including some cognitive aspects that had previously been thought to get worse. John Verssimo, of the University of Lisbon, and his colleagues, looked at a large sample of people between the ages of 58 and 98 and measured their performance on a broad range of cognitive tasks to get a more detailed picture of cognitive aging. They controlled for participants’ sex and education, as well as declines in general thinking speed, motor control, and perception, and found some surprising and hopeful results. 

The broad strokes of the traditional thinking on lifespan psychology is that people improve in all kinds of cognition until their early 20s. After that, " fluid intelligence , which includes thinking about new things, thinking quickly, and abstract reasoning, gradually declines until the end of life.  " Crystalized" intelligence, on the other hand, which is characterized by wisdom, knowledge, and expertise at things one practices often, continues to improve with age, but with slower returns as we get older. This continues into your 70s, after which things begin to decline.

But, as cognitive psychologists have suggested some of the aspects of fluid intelligence, such as attention, can be broken down into component parts—like alerting, orienting, and executive control. Alerting covers one’s vigilance and preparedness for responding to information coming in. This is important for driving, for example. Orienting is one’s ability to select some perceptual information over others based on what’s important. Executive control refers to one’s ability to inhibit all the information that orienting deemed unimportant, such as the  conversations at other tables in a restaurant. These abilities are somewhat independent, and even involve different neural substrates. “Given that these attention/executive functions show neurocognitive differentiation,” Verssimo and his colleagues write, “we suggest that they may also show distinct susceptibilities to aging.”

Does age affect fluid intelligence broadly, as has been traditionally believed? Or, given that these components are anatomically distinct, might aging affect each one differently?

To find out, Verssimo and his colleagues used a common measurement tool, the Attention Network Test, which provides individual scores for alerting, orientation, and executive function. As expected, older people are slower in general, as measured by their response time in the task (how fast they hit a button in response to something on the screen), at the rate of an average increase of 6.3 milliseconds per additional year of age. But there were differences in the components: alerting got worse with increasing age but orienting, and the ability to inhibit irrelevant information, got better. There are ways we get smarter with age, even in the domain of fluid intelligence.

“Thus, our findings, together with other data, argue against theories positing general age-related declines in attention and executive function,” the researchers write. “Even though aging is widely viewed as leading to cognitive declines, it in fact yields multifaceted outcomes, including a range of benefits.”

Many decisions a president has to make require careful thought, and the important decisions never need to be made so fast that milliseconds make a difference. These days, presidents don’t even drive themselves. And given that age tends to increase abilities in vocabulary, language comprehension, reading others’ emotions, and knowledge, perhaps American candidates being in their 70s shouldn’t worry us too much. At least as far as brain power goes.

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Sunday, June 09, 2019

Respiratory disorders in children can now be detected via smartphone

The diagnosis of childhood respiratory disorders can now be readily done with an automated cough analysis technology incorporated in a smartphone app, according to a recent study. This system delivers high diagnostic accuracy ( between 81-97%) in detecting respiratory disorders, including pneumonia, RAD, croup, bronchitis, upper and lower respiratory tract disorders.

In children, respiratory disorders are the 2nd most common reason for admission to the emergency department and is a major disease burden worldwide. The differential diagnosis of respiratory disorders can be challenging even for experienced clinicians with access to diagnostic support services.


Diagnostic delays and errors can result in an increased risk of morbidity, antibiotic stewardship and mortality.


Researchers compared diagnoses made by the algorithm to those from a clinical adjudication panel ( who had access to all medical records and diagnostic support service results) in order to determine positive and negative percent agreement for a number of respiratory conditions.


It can be difficult to differentiate between respiratory disorders in children, even for experienced doctors.This study demonstrates how new technology, mathematical concepts, machine learning and clinical medicine can be successfully combined to produce completely new diagnostic tests utilising the expertise of several disciplines, said a Dr.


To develop the app, the authors used similar technology to that used in speech recognition, which they trained to recognise features of coughs which are characteristic of 5 different respiratory diseases. The researchers then used the app to categorise the coughs of 585 children between ages 29 days to 12 years who were being cared for at 2 hospitals.


The accuracy of the automated cough analyser was determined by comparing its diagnosis to a diagnosis reached by a panel of pediatricians after they had reviewed results of imaging, laboratory findings, hospital charts and conducted all available clinical investigations.


The authors note that the technology developed for this study is able to provide a diagnosis without the need for a clinical examination by a doctor in person, addressing a major limiting feature of existing telehealth consultations, which are used to provide clinical services remotely. removing the need for a clinical examination may allow targeted treatments to begin sooner.


The Dr. said, as the tool does not rely on clinical investigations, it can be used by health care providers of all levels of training and expertise. However, we would advise that where possible the tool should be used in conjunction with a clinician to maximise the clinical accuracy.


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Read more at Speciality Medical Dialogues: Respiratory disorders in children can now be detected via smartphone https://speciality.medicaldialogues.in/respiratory-disorders-in-children-can-now-be-detected-via-smartphone/

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