Are Your Organs Ageing Well? This Blood Test Can Tell

Researchers suggest that blood tests could be used to determine the biological age of a person's organs, which would allow them to address health issues before they manifest. According to a study undertaken by US scientists, the method could also be utilized to predict the progression of illnesses such as Alzheimer's disease. Research suggests that individuals whose organs age faster than the rest of their bodies are at an increased risk of developing organ-specific diseases within 15 years.

The team, led by researchers from Stanford University in California, used machine learning to analyze protein levels in human blood. The study focused on 11 organs, organ systems, or tissues, including the brain, heart, lungs, kidneys, liver, pancreas, and intestines, as well as the immune system, muscles, fat, and vasculature.

To develop their algorithm, the researchers looked at the protein levels in the blood of 1,398 healthy people at the Knight Alzheimer's Disease Research Center, ranging in age from 20 to 90, with a concentration on the middle to late stages of life. 

 

The researchers identified 858 organ-specific proteins by analyzing nearly 5,000 proteins and pinpointing those with genes that displayed a fourfold increase in activation in one organ as compared to another organ. Subsequently, the algorithm was trained to estimate a person's age using these specific proteins. 

 

The study’s senior author, Tony Wyss-Coray, a professor of neurology and the DH Chen Professor II at Stanford University, said: “We can estimate the biological age of an organ in an apparently healthy person. That, in turn, predicts a person’s risk for disease related to that organ.”

The researchers tested their technique on a total of 5,676 patients from five separate cohorts. The findings, published in Nature, revealed that roughly 20% of the patients had a significant acceleration of aging in a specific organ, with 1.7% having aging effects in several organs.

They also discovered that accelerated organ aging was associated with a 20% to 50% increase in mortality risk. Individuals with accelerated heart aging were 250% more likely to develop heart failure, but rapid aging in the brain and vascular system outperformed the most effective available blood-based biomarker in predicting Alzheimer's progression. 

 

In the future, Professor Wyss-Coray believes the finding may help us identify organs undergoing rapid aging in people's bodies and treat them before they become ill if it can be replicated in a larger sample of 50,000 to 100,000 people.

 

The development of more accurate and less intrusive methods for detecting signals of age-related disorders, such as the early symptoms and progression of Alzheimer's, is an essential step toward curing them. Continuous research is needed to enhance and evaluate tools of this type, putting us ahead in the fight against these diseases.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
https://cancersupportindia.blogspot.com  for infor on cancer and health related topics
https://GSiyers home remedies.blogspot.com   is the latest addition to my blogs. I'm going to add posts there, do give me your valuable feed back on my blogs. Thanks a lot, take care, be healthy and be happy.

New swallowable sensors to monitor human gut health

Scientists have successfully completed the first human trials of an ingestible capsule that can monitor gases in the gut in real time, potentially revolutionising the way stomach and colon disorders are diagnosed.

The capsule can uncover mechanisms in the body that have never been seen before, including a potentially new immune system, researchers said.

The new technology is a game-changer for the one-in-five people worldwide who will suffer from a gastrointestinal disorder in their lifetime. They could also lead to fewer invasive procedures like colonoscopies, they said.

The ingestible capsule developed by researchers detects and measures gut gases — hydrogen, carbon dioxides and oxygen — in real time. This data can be sent to a mobile phone.

“We found that the stomach releases oxidising chemicals to break down and beat foreign compounds that are staying in the stomach for longer than usual,” said a Dr.

“This could represent a gastric protection system against foreign bodies. Such an immune mechanism has never been reported before,” said the co-inventor of the capsule.

Another never before seen observation from the trial was that the colon may contain oxygen.

“Trials showed the presence of high concentrations of oxygen in the colon under an extremely high-fibre diet,” the Dr. said.

“This contradicts the old belief that the colon is always oxygen free. This new information could help us better understand how debilitating diseases like colon cancer occur,” he said.

The trials were conducted on seven healthy individuals on low- and high-fibre diets.

Results showed that the capsule accurately shows the onset of food fermentation, highlighting their potential to clinically monitor digestion and normal gut health.

The trials also demonstrated that the capsule could offer a much more effective way of measuring microbiome activities in the stomach, a critical way of determining gut health.

“Previously, we have had to rely on faecal samples or surgery to sample and analyse microbes in the gut,” the Dr. said.

“But this meant measuring them when they are not a true reflection of the gut microbiota at that time. Our capsule will offer a non-invasive method to measure microbiome activity,” he said. 

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.    
 
PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                      
HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                       

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/
FOR CROCHET DESIGNS
HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM