Insulin may boost breast milk supply

Scientists have found that the hormone insulin may play an important role in breast milk production, a finding that can help explain why many mothers have difficulty making enough milk to breastfeed.

Researchers  found insulin to be responsible for lactation success.

The study is the first to describe how the human mammary gland becomes highly sensitive to insulin during lactation. It is also the first study to get an accurate picture of how specific genes are switched on in the human mammary gland during lactation.

The researchers used next generation sequencing technology, RNA sequencing, to reveal "in exquisite detail" the blueprint for making milk in the human mammary gland, according to  author of the study.

For a long time, insulin was not thought to play a direct role in regulating the milk-making cells of the human breast, because insulin is not needed for these cells to take in sugars, such as glucose.

Scientists now, however, appreciate that insulin does more than facilitate uptake of sugars. This new study shows a dramatic switching on of the insulin receptor and its downstream signals during the breast's transition to a bio-factory that manufactures massive amounts of proteins, fats and carbohydrates for nourishing the newborn baby.

Researchers were able to use a non-invasive method to capture mammary gland RNA - a chain of

molecules that are blueprints for making specified proteins - in samples of human breast milk. They then created the first publicly accessible library of genes expressed in the mammary gland based on RNA-sequencing technology.

This approach revealed a highly sensitive portrait of the genes being expressed in human milk-making cells. They discovered an orchestrated switching on and off of various genes as the mammary gland transitions from secreting small amounts of immunity-boosting colostrum in the first days after giving birth to the copious production of milk in mature lactation.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a bio-marker linking insulin resistance with insufficient milk supply.

Now that they've demonstrated the significance of insulin signalling in the human mammary gland, scientists are planning a phase I/II clinical trial with a drug used to control blood sugar in type 2 diabetes to determine whether it improves insulin action in the mammary gland, thus improving milk supply.

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

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ACCORDING TO A NEW STUDY, COW'S MILK PROTECTS AGAINST HIV

Cows’ milk can be potentially developed into affordable 

creams that can help protect humans against HIV, a study 

has claimed.

Scientist from University of Melbourne found that when 

pregnant cows were vaccinated with an HIV protein, the first 

milk produced by the cow after giving birth, called colostrum, 

produced high antibodies to protect its newborn against 

disease.

Researchers were now planning to test the effectiveness and 

safety of the milk before turning it into a cream which will 

hopefully allow women to protect themselves against 

contracting the virus during sex, without relying on men.

However, the final result could be a decade off.

The researchers were able to inhibit the virus from infecting 

cells when combing the virus cells with milk.

We think the antibodies bind to the surface of the virus and 

blocks the protein which needs to be freed to get in contact 

with human cells — like a key and lock system. It’s a very 

cheap and easy way to produce a lot of antibodies.

We have the antibodies at the moment — the next step will 

be formulation.

Condoms were “cheap and easy” but not an option for 

everyone with millions of people getting infected with HIV 

every year.

A lot of women, especially in Africa or South America they 

don’t have the power to say you need to use a condom before 

we have sex.

This milk looks like it can be a cheap, easy new prevention 

tool, because if you use drugs it’s really expensive.