New monoclonal antibody safe and effective for rare liver disease

A new monoclonal antibody treatment has shown promising results for a rare liver disease called primary sclerosing cholangitis (PSC).  The team from the University of California-Davis, US, tested an anti-inflammatory and anti-fibrotic monoclonal antibody known as nebokitug and found it to be safe and potentially effective in patients with PSC. Published in the American Journal of Gastroenterology, the results offer encouraging news for patients with PSC, for which there are currently no effective treatments short of liver transplantation. "In the trial, nebokitug demonstrated that it has the potential to change the lives of patients with PSC by reducing fibrosis and inflammation, which should lead to improved outcomes," said Christopher Bowlus, chief of Gastroenterology and Hepatology at UC Davis Health.

"These results are good news for patients with PSC, who are in desperate need of an effective, FDA-approved therapy."

PSC is a rare, chronic liver disease that causes inflammation and scarring of the bile ducts. These ducts carry bile from the liver to the small intestine to help digest fats. When they become damaged and narrow, bile builds up in the liver, leading to liver injury over time.

The exact cause of PSC is not fully understood, but most patients also have inflammatory bowel disease, suggesting a direct link between intestinal inflammation and the liver.

Symptoms can include fatigue, itching, and jaundice, though some people have no symptoms at first. There is no cure, and treatment focuses on managing symptoms and complications. In advanced cases, a liver transplant may be needed.

Nebokitug is a lab-made antibody designed to block a protein called CCL24. This protein plays a role in inflammation and scarring by interacting with certain inflammatory cells in the liver.

In PSC, CCL24 levels are higher than normal and are found around the bile ducts, where they contribute to liver damage. Studies have shown that blocking CCL24 can reduce these harmful processes.

For the Phase 2 trial, 76 PSC patients across five countries were randomly assigned to receive nebokitug at two different doses or a placebo through an IV every three weeks for 15 weeks. The main goal was to check safety.

Results showed nebokitug was safe and well-tolerated. Patients, especially those with more advanced liver scarring, had improvements in key measures like liver stiffness and fibrosis markers compared to placebo. (IANS)are damaged.

The findings open a new window into how cardiovascular changes contribute to cognitive decline and may offer novel prevention strategies.

 

 

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Scientists Discover a New Benefit of Drinking Coffee

Coffee is one of the most controversial drinks in existence. In the past, many believed that it causes cardiovascular disease, but more recent research suggests that the antioxidant-rich drink actually has numerous health benefits, provided that you don’t drink more than a few cups of coffee every day. Among the notable health benefits of coffee are improved heart and brain health, as well as a reduced risk of certain types of cancer. But there’s one more health benefit we can now confidently add to that list - liver health.

This is the biggest study yet to find that coffee benefits liver health

Liver disease is a widespread health issue all around the world, and it’s on the rise too. More recent estimates suggest that one in ten Americans suffers from some kind of liver disease. Fatty liver disease and liver cirrhosis are among the most common kinds of liver disease. According to a recent study from the United Kingdom, drinking coffee lowers one’s risk of liver disease.

The study followed 495,585 people for 10 years. 78 percent of the participants consumed ground coffee, instant coffee, or decaf, whereas the remaining 22 percent didn’t drink coffee. Over the ten-year period, 3,600 cases of fatty liver disease and 184 cases of liver cancer were recorded.

The study found that liver disease was more common among the participants who didn’t drink coffee. Among the coffee drinkers, the risk of liver disease fell by 21 percent and the risk of death from chronic liver disease was reduced by 49 percent compared to those who didn’t drink coffee. Researchers believe that the anti-inflammatory or anti-fibrotic properties of coffee may be why it’s beneficial for liver health.

“There are previous studies suggesting lower risk of cirrhosis (severe liver scarring), improvements in fatty liver disease, lower rates of hospitalization and mortality in cirrhosis, associated with coffee use,” stated Dr. Albert Do, a Yale Medicine hepatologist and fatty liver disease expert to Healthline. So this study is a big contribution to an already existing belief among experts that coffee is beneficial for the liver. The researchers conclude that coffee is an accessible and affordable drink capable of reducing one’s risk of liver disease.

Do instant, decaf, and ground coffee have the same effect?

Although both decaf and instant coffee were associated with some health benefits, the beneficial effect was the strongest in the group who drank ground coffee. The researchers believe that this is due to the fact that ground coffee has the most cafestol and kahweol — two compounds naturally present in coffee believed to protect the liver. This doesn’t mean that you should switch to ground coffee, as you’ll still experience some benefits from decaffeinated coffee, especially if you opt for decaf for health reasons.

How much coffee one should drink to feel the effects?

The study found that the health benefits plateaued at 4-5 cups of coffee daily. This doesn’t mean that you should drink that much, but rather that there’s no point in drinking more than 4 cups of coffee a day. Even if you drink 1-2 cups of coffee a day, you should experience the same benefits. 

 

 Experts usually don’t recommend drinking more than 400mg of coffee a day (which is about 3-4 cups of coffee) because all the benefits of coffee are only relevant when consuming caffeine in moderation. The moment you increase your caffeine intake to more than 400 mg a day, the negative effects, such as a racing heart and cardiovascular issues start to kick in. 

 

Those who suffer from heart disease, high blood pressure, and heartburn should be especially careful when drinking any amount of coffee. With that said, those who enjoy their morning coffee daily will probably be glad to find out that their coffee drinking habit is healthier than they think.

 

 

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

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Scientists Discover a New Benefit of Drinking Coffee

Coffee is one of the most controversial drinks in existence. In the past, many believed that it causes cardiovascular disease, but more recent research suggests that the antioxidant-rich drink actually has numerous health benefits, provided that you don’t drink more than a few cups of coffee every day. Among the notable health benefits of coffee are improved heart and brain health, as well as a reduced risk of certain types of cancer. But there’s one more health benefit we can now confidently add to that list - liver health.

This is the biggest study yet to find that coffee benefits liver health  

Liver disease is a widespread health issue all around the world, and it’s on the rise too. More recent estimates suggest that one in ten Americans suffers from some kind of liver disease. Fatty liver disease and liver cirrhosis are among the most common kinds of liver disease. According to a recent study from the United Kingdom, drinking coffee lowers one’s risk of liver disease.

The study followed 495,585 people for 10 years. 78 percent of the participants consumed ground coffee, instant coffee, or decaf, whereas the remaining 22 percent didn’t drink coffee. Over the ten-year period, 3,600 cases of fatty liver disease and 184 cases of liver cancer were recorded. 

 

The study found that liver disease was more common among the participants who didn’t drink coffee. Among the coffee drinkers, the risk of liver disease fell by 21 percent and the risk of death from chronic liver disease was reduced by 49 percent compared to those who didn’t drink coffee. Researchers believe that the anti-inflammatory or anti-fibrotic properties of coffee may be why it’s beneficial for liver health. 

 

“There are previous studies suggesting lower risk of cirrhosis (severe liver scarring), improvements in fatty liver disease, lower rates of hospitalization and mortality in cirrhosis, associated with coffee use,” stated Dr. Albert Do, a Yale Medicine hepatologist and fatty liver disease expert to Healthline. So this study is a big contribution to an already existing belief among experts that coffee is beneficial for the liver. The researchers conclude that coffee is an accessible and affordable drink capable of reducing one’s risk of liver disease.

 

Do instant, decaf, and ground coffee have the same effect?

Although both decaf and instant coffee were associated with some health benefits, the beneficial effect was the strongest in the group who drank ground coffee. The researchers believe that this is due to the fact that ground coffee has the most cafestol and kahweol — two compounds naturally present in coffee believed to protect the liver. This doesn’t mean that you should switch to ground coffee, as you’ll still experience some benefits from decaffeinated coffee, especially if you opt for decaf for health reasons. 

 

How much coffee should drink to feel the effects? 

The study found that the health benefits plateaued at 4-5 cups of coffee daily. This doesn’t mean that you should drink that much, but rather that there’s no point in drinking more than 4 cups of coffee a day. Even if you drink 1-2 cups of coffee a day, you should experience the same benefits. 

 

Experts usually don’t recommend drinking more than 400mg of coffee a day (which is about 3-4 cups of coffee) because all the benefits of coffee are only relevant when consuming caffeine in moderation. The moment you increase your caffeine intake to more than 400 mg a day, the negative effects, such as a racing heart and cardiovascular issues start to kick in. 

 

Those who suffer from heart disease, high blood pressure, and heartburn should be especially careful when drinking any amount of coffee. With that said, those who enjoy their morning coffee daily will probably be glad to find out that their coffee drinking habit is healthier than they think.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement