Fatty liver breakthrough: A common vitamin shows promise in the study

Metabolic-associated fatty liver disease (MASLD( impacts roughly 30 % of people globally and has long lacked effective, targeted therapies. Now, researchers have uncovered a key genetic factor that worsens the condition. Even more surprising, the most effective way to target this factor may be an already and widely available treatment: Vitamin B 3.

An international research team has identified micro RNA-93 (miR-93) as a central regulator in MASLD. This marks the first time this molecule has been early linked to how the disease develops and progresses.

How miR-93 Disrupts Liver Function

MiR-93 is a small RNA molecule found in liver cells that controls the activity of certain genes. The researchers discovered that levels of miR-93 are unusually high in both people with fatty liver disease and in animal models. Their analysis showed that miR-93 drives fat buildup, inflammation, and scarring in the liver by suppressing SIRT1m a gene that plays a key role in managing fat metabolism inside liver cells.

To better understand its role, the team used gene editing to stop the production of miR-93 in mice. These animals showed significantly less fat accumulation in the liver, along with improved insulin sensitivity and better overall liver function. In contrast, mice engineered to produce excess miR-93 experiences more severe metabolic problems in the liver.

Vitamin B3 Emerges as a Potential Treatment

The researchers then screened 150 FDA-approved drugs to see if any could reduce miR-93 levels. Niacin ( Vitamin B3) stood out as the most effective option. In mice treated with niacin, miR-93 levels dropped sharply, while SIRT1 activity increased. This helped restore normal fat-processing pathways I the liver and improved overall lipid balance.

The research team explained, “ This study precisely elucidates the molecular origin on MASLD and demonstrates the potential for repurposing an already approved vitamin compound to modulate this pathway, which has high translational clinical relevance”.

They added, “ Given that niacin is a well-established and safe medication used to treat hyperlipidemia, it holds promise as a candidate for combination therapies targeting miRNA pathway in MASLD.”

 

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IMPORTANCE OF B-VITAMINS

Vitamin B is a complex of 8 vitamins, which not only essential for a good health, but also enables smooth functioning of various functions of the body. Further, each of the vitamin B complexes has specific body functions ranging from iron metabolism to hair health to preventing migraine. Our body requires vitamin substances, as stated by their names.

• Vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6, B7 (biotin), B9 (folate), B12.
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• Vitamin B complex is widely present in food sources, and in someone who eats a well-balanced diet would be getting the required amounts of vitamin B complex.
• Vitamin B1, also known as thiamine, is required for the body to make new cells and so has a significant role in the immune system. It has also known as the anti-stress vitamin as it helps in improving immunity. It also is required for breakdown of carbohydrates.
• Vitamin B2, chemically known as riboflavin, is essential for red blood cell production and transporting oxygen throughout the body. It also has antioxidant properties by reducing free radicals. This also has anti-aging properties and reduces the onset of heart disease.
• Vitamin B3, also known as niacin, is essential for cholesterol regulation. It promotes the formation of good cholesterol and so essential for preventing the onset of heart disease. It also is shown to have anti-acne effects.
• Vitamin B5, pantothenic acid, is essential for fat and carbohydrate metabolism. It also is required for the production of hormones including testosterone and cortisol (stress hormones). It is also beneficial to the skin by reducing anti-aging effects including reducing brown spots.
• Vitamin B6 or pyridoxine, has a major role to play in sleep and mood regulation. It produces various neurotransmitters like serotonin, melatonin, and norepinephrine which are essential for emotional well-being. It also has anti-inflammatory properties and is useful in conditions like rheumatoid arthritis.
• Vitamin B7 or Biotin is known as the beauty vitamin, as it has major hair, skin, and nail benefits. It is also essential for glucose level maintenance. It assumes great importance in pregnancy as it is important for normal growth of the baby.
• Vitamin B9 or folate or folic acid is again very essential in pregnancy as deficiency can lead to neurological defects in the developing baby. It also plays a major role in carrying oxygen to the cells through the RBCs.
• Vitamin B12 or cobalamin is essential to ensure the other vitamins are functioning properly. B12 deficiency leads to anaemia, as it enables the red blood cells to carry oxygen throughout the body. It is mostly present in non-vegetarian foods and supplements are commonly given in anaemic people.
   this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.
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  https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes 
  https://kneereplacement-stickclub.blogspot.com. for info on knee replacement