Monday, October 07, 2019

Probiotics could help end malnutrition in next 20 years, Bill Gates says

Bill Gates has said he believes probiotics could help solve malnutrition over the next two decades.
On Monday morning, the Microsoft co-founder published an essay about the devastating impact of malnutrition.

The philanthropist stated that malnutrition is the “greatest health inequity in the world”, accounting for half of all childhood deaths in sub-Saharan Africa.

Gates explained that malnutrition causes the wasting away of the body and the stunting of growth, something that may be combatted by a “deeper understanding” of the “microbiome of the human body”.

“All of us rely on our body’s microbiome to function properly. We have more microbial cells living inside our bodies than human cells,” he wrote.
“These bacteria protect us from infection and are particularly essential to digestion. For example, your body literally cannot break down certain types of plant fibres without an assist from the bacteria in your gut.”

Gates stated  that the scientific community is “in the relatively early stages of research into the microbiome”, adding that more knowledge will be garnered regarding individual microbial species over the next 10 to 20 years.

“That knowledge will allow us to smartly engineer interventions that ‘correct’ the microbiome when it’s out of whack,” he said.

“You’re probably familiar with one of these interventions: probiotics.”

The co-founder of the Bill and Melinda Gates Foundation, which is committed to improving nutrition  for women and children across the world, explained how in the future, scientists will be able to “create next-generation probiotic pills that contain ideal combinations of bacteria”, some of which could be “tailored to your specific gut”.

“If we can figure nutrition out – and I believe we will within the next two decades – we’ll save millions of lives and improve even more,” Gates concluded.

Probiotics are live bacteria and yeasts that are believed to be beneficial for the health of the gut, the NHS explains.

They can usually be found in food products such as yoghurt or taken as food supplements.

However, the NHS warns that as probiotics are usually categorised as food as opposed to medicine, they are not tested in the same way that medicinal products would be.

“There’s likely to be a huge difference between the pharmaceutical-grade probiotics that show promise in clinical trials and the yoghurt and supplements sold in shops,” the health agency outlines.

Earlier this year, it was reported that hunger was the cause for almost half of all child deaths in Africa.

A report released by the African Child Policy Forum found that in 2018, 60 million African children were stunted in growth.

The report also said that 90 per cent of all children in Africa are malnourished or undernourished, and 60 per cent do not meet the minimum meal frequency threshold set by the World Health Organisation  (WHO).

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Monday, September 29, 2014

Scientists discover early signs of pancreatic cancer

  Scientists have discovered the early signs of pancreatic cancer that show the symptoms for the disease.

Scientists at Dana-Farber Cancer Institute, of the Massachusetts Institute of Technology (MIT), US, identified that an upsurge in certain amino acids that occurs before the disease is diagnosed, is a sign of the early development of the disease.

Although the increase wasn't large enough to be the basis of a new test for early detection of the disease, the findings would help researchers understand better how pancreatic cancer affected the rest of the body, particularly how it could trigger the sometimes deadly muscle-wasting disease known as cachexia.

The researchers utilised blood samples collected years earlier from 1,500 people participating in large health-tracking studies. They analysed the samples for more than 100 different metabolites, substances produced by the metabolic process, and compared the results from participants  who had gone on to develop pancreatic cancer and those who had not.

Brian Wolpin, co-senior author of the new study said they found that the higher levels of branched chain amino acids were present in people who went on to develop pancreatic cancer compared to those who did not develop the disease.

The amount of time that would elapse before those individuals were diagnosed with pancreatic cancer ranged from two to 25 years, although the highest risk was several years before diagnosis, the researchers found. Wolpin added that it helped them to hypothesise that the increase in branched chain amino acids was due to the presence of an early pancreatic tumor.

The researchers found the increase was due to a breakdown of muscle tissue, which caused branched amino acids to be released into the bloodstream. The process was similar to what occurs in patients with cancer cachexia.

The study is due to be published in the journal Nature Medicine.


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