Simple blood test to improve ovarian cancer diagnosis

A new study, published in the journal Scientific Reports, found that testing for a specific immune biomarker allows clinicians to identify whether growths on the ovaries are cancerous or not, without the need for tests like the MRI scans or ultrasounds. Ovarian cancer is one of the most common gynaecologic cancers, with the highest mortality rate. About 300,000 new cases are diagnosed globally each year, with an estimated 60 per cent of women dying within five years after diagnosis.

“Our new test is as accurate as the combined results of a standard blood test and ultrasound. This is especially important for women in remote or disadvantaged communities, where under-resourced hospitals may not have access to complex and expensive equipment like ultrasound machines or MRI scanners,” said study senior author Magdalena Plebanski from the RMIT University in Australia. “It also means patients with benign cysts identified through imaging could potentially be spared unnecessary surgeries,” Plebanski added.

According to the researchers, the test could be an important diagnostic tool for assessing suspicious ovarian growths before operations. “This study looked at women with advanced ovarian cancer, but we hope further research could explore the potential for adding this biomarker to routine diagnostic tests at earlier stages of the disease,” Plebanski said.

The study used an immune marker for inflammation (IL-6) together with cancer markers to detect epithelial ovarian cancer in blood. According to the researchers, results were validated across two separate human trial cohorts. “Every day in Australia, four women are diagnosed with ovarian cancer and three will die from the disease,” Plebanski said.

“Developing tests that are simpler and more practical may help get more women to hospital for treatment more effectively, with the hope that survival rates will improve,” Plebanski concluded.

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Simple blood test detects cancer!

A simple blood test now has the potential to diagnose cancer!

A new collaborative study of scientists from India, US and the UK on 16,134 patients drawn from major Indian cities has presented clinical evidence for an innovative test that can detect clusters of cancer cells in the blood, through a simple diagnostic method.

The first of its kind study, which was published in the recent edition of International Journal of Cancer (IJC), holds promise for making cancer screening easier, efficient and affordable in the country. The simple blood test will soon be available commercially.

Dr Vineet Datta, Executive Director, Datar Cancer Genetics, who is involved with the research, during his visit to Hyderabad on Friday said the first of its kind study had established definitive new systemic hallmark to detect cancers.

“The technique we have used is a breakthrough innovation. When clusters of cells break off from an early stage tumour and enter the bloodstream, we can efficiently and accurately isolate a few hundred malignant cells from more than 100 million cells, using just 10 ml of blood. While almost all cancer samples had these cell clusters, they were seen in very few of the samples which were apparently without cancer,” researchers explained.

Dr Tim Crook, Medical Oncologist, St Luke’s Cancer Centre, Royal Surrey County Hospital, UK, who is attending a cancer conference in Hyderabad and is involved in the study, said that the innovative blood-based test will impact outcomes through easy, patient-friendly detection and diagnosis in apparently healthy people who may have a silent malignancy in their bodies.

It has the potential to eliminate the need for invasive biopsies and the risks associated with it. In the near future, a simple, inexpensive blood test that could be all that is required to reliably detect and diagnose cancer, researchers said.

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This Simple Blood Test Can Predict Cancer as Accurately as a Lump in The Breast

A common blood test has shown to be just as accurate in predicting any type of cancer as a lump is for breast cancer, and researchers say it's the most promising detection method for cancer in 30 years.

A high number of platelets (tiny blood cells that help wounds clot) have been linked to an increased risk of all forms of cancer, and scientists are now urging doctors to consider thrombocytosis - a condition where too many platelets are produced in the body - as a detection method for patients who are yet to show symptoms.
 
"Our findings on thrombocytosis show a strong association with cancer, particularly in men - far stronger than that of a breast lump for breast cancer in women," says one of the team, Willie Hamilton from the University of Exeter in the UK.


"It is now crucial that we roll out cancer investigation of thrombocytosis. It could save hundreds of lives each year."

Thrombocytosis affects around 2 percent of people over the age of 40, and it's been linked to cancer before. What this new study does is establish a stronger link across all ages and genders, and with cancer in all areas of the body.

The researchers looked at 31,261 records of patients in the UK with a high platelet count (thrombocytosis), and 7,969 records of patients whose platelet count was normal.

They found that 11.6 percent of males with thrombocytosis went on to be diagnosed with cancer within a year, compared to 4.1 percent of those without. For females, cancer developed in 6.2 percent of those with thrombocytosis, compared to 2.2 percent without.

If a second high platelet count was recorded within six months, those risks went even higher: 18.1 percent for males and 10.1 percent for females.

A lump on the breast turns out to be cancerous in around 8.5 percent of cases for women aged 50 to 59 years, by comparison.
The researchers report that Lung and colorectal cancer were the types most commonly linked to thrombocytosis.

What's more, one-third of those with lung or colorectal cancer had no other symptoms of the disease apart from thrombocytosis - which means this could be a very important indicator in the future for cases when cancer wouldn't otherwise be spotted so soon.

The team says this the first new indicator of cancer to have been clearly identified in the last three decades, with the potential to identify thousands of cancers earlier and save hundreds of lives a year.

While early diagnosis is just one of many factors that affect the chances of someone getting better, it's known to improve survival rates across all types of cancer.

"We know that early diagnosis is absolutely key in whether people survive cancer," says one of the team, Sarah Bailey.

"Our research suggests that substantial numbers of people could have their cancer diagnosed up to three months earlier if thrombocytosis prompted investigation for cancer. This time could make a vital difference in achieving earlier diagnosis."

The research has been published in The British Journal of Medical Practice.

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