Sensor To Detect Vitamin B12 Deficiency In a Jiffy

Researchers from University of Adelaide have developed a world's first optical sensor that can detect vitamin B12 in diluted human blood - a novel step towards developing a low-cost and portable deficiency test.

Vitamin B12 deficiency is associated with an increased risk of dementia and Alzheimer's disease.

Such a device would enable the tracking of vitamin B12 levels in high-risk patients and early intervention can help overcome the limitations of current testing methods which are time-consuming and costly.

"Vitamin B12 deficiency has been shown to be a potential modifiable risk factor for dementia and Alzheimer's disease and is associated with cognitive decline," said Dr Georgios Tsiminis, Research Fellow at University of Adelaide.

Older adults are particularly at risk of B12 deficiency due to age-related reduction in absorbing vitamin B12 received through their diet.

"Our sensor is an early step towards a point-of-care solution for measuring and tracking B12 in healthy ageing adults. This would allow doctors to monitor B12 levels and intervene as soon as B12 deficiency was detected," Dr Tsiminis added.

The sensor is still at proof-of-concept stage but, with development, has wide-reaching potential applications.

The optical sensor measurement of B12 in human blood takes less than a minute and requires minimum preparation.

This is the first demonstration of vitamin B12 being measured in human blood serum without the need for a full laboratory test.

The sensor uses an optical measuring technique called Raman spectroscopy which produces a unique optical fingerprint of a target molecule, in this case vitamin B12.

"Our method provides a realistic basis for a system that is portable, cost-effective, and affords rapid results, along the lines of the pin-prick test for diabetes," Dr Tsiminis noted in a statement.

The research by scientists in the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), the Institute for Photonics and Advanced Sensing, and the Schools of Physical Sciences and Medicine was presented at an international biophotonics conference in Adelaide last weekend.

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New sensor to detect cancer, HIV

The sensor can detect viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others.


Researchers have developed a highly sensitive nanomechanical sensor that can detect cancerous tumours as well as viral disease markers for HIV, hepatitis and herpes.

Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.

The sensor can detect viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others. The sensor will also enable doctors to identify tumour markers, whose presence in the body signals the emergence and growth of cancerous tumours.

The highly sensitive sensor will allow for diagnosing diseases long before they can be detected by any other method, which will pave the way for a new-generation of diagnostics, researchers said. Calculations done by the researchers, Dmitry Fedyanin and Yury Stebunov, showed that the new sensor will combine high sensitivity with a comparative ease of production and miniature dimensions, allowing it to be used in all portable devices, such as smartphones, wearable electronics, etc.

One chip, several millimetres in size, will be able to accommodate several thousand such sensors, configured to detect different particles or molecules, researchers said. The device, described in a study published in the journal Scientific Reports, is an optical or, more precisely, optomechanical chip.

"We've been following the progress made in the development of micro- and nanomechanical biosensors for quite a while now and can say that no one has been able to introduce a simple and scalable technology for parallel monitoring that would be ready to use outside a laboratory," the researchers said. "So our goal was not only to achieve the high sensitivity of the sensor and make it compact, but also make it scalabile and compatibile with standard microelectronics technologies," researchers said.

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