These are 4 early signs of Alzheimer’s disease

You can recognise Alzheimer’s disease by these symptoms

In a lot of cases, dementia is connected to Alzheimer’s disease. No less than one in 14 people over 65 gets Alzheimer’s and for people over 85 that number is at one in six people. It’s important to recognise the signals and symptoms at an early date.

Of all types of dementia, Alzheimer’s is the most common one.

Causes of Alzheimer’s

Alzheimer’s is a type of dementia. The term ‘Alzheimer’ is often confused with a more general type of dementia, but this isn’t correct. With Alzheimer’s disease, there’s definitely dementia, but not all people with dementia have Alzheimer’s. Alzheimer’s is a syndrome that is degenerative in nature, which means it gets worse over time. There’s an ongoing decline in brain function. Certain proteins called plaques and tangles are deposited in the brain. These proteins restrict the communication between nerve cells, which eventually affects the memory. There’s no scientific proof for these proteins causing Alzheimer’s. However, together with high blood pressure and a high cholesterol level, this does increase the risk of developing the disease. The exact cause for the disease isn’t known yet.

Symptoms

An important aspect of this disease is that it starts off slowly and gets worse over time. These are a couple of symptoms that will help you recognise Alzheimer’s disease:

• Memory loss: This is the most common symptom. People start to have trouble retaining new information. They start to forget things about recent events of conversations, for example. Problems with reading, talking, writing and maths start to arise as well.
• Cognitive functions: The ability to think, judge/decide and understand is slowly lost. Taking initiative and acting independently starts to become difficult. Social skills start to degenerate and people can get disoriented about time and/or place.
• Losing grip on reality: Alzheimer patients can start to become suspicious or paranoid. Half of all patients have delusions: beliefs that don’t comply with reality. Because of the paranoia and suspicions, patients can think they’ve been stolen from or lied to by their partners or carers. Hallucinations are also a common symptom.
• Problems with everyday activities: Activities that have always been the most natural thing in the world are now done with more difficulty and clumsiness. At the same time, common social relations can remain intact for a long time. This is why it might appear to the outside world as if everything is alright.

Treatment

There is still no cure for Alzheimer’s, but there are certain medicines and therapies that can help make the lives of patients a little bit easier. There are medicines that are said to inhibit early Alzheimer’s, but the opinions on these medicines are divided. Several doctors claim that the side effects of the medicines are bigger than the inhibitory effect on the brain disease. Therapy is mostly about support and guidance and focuses on the question: “How can we make sure the patient feels most comfortable and safe?” The goal is to make sure patients can live at home for as long as possible. People with Alzheimer’s are said to function better when they still live at home.

 

 

New insights on inflammation promoting heart disease

A new study has found that bone marrow factors lead to increased production of w ..

Read more at:
https://health.economictimes.indiatimes.com/news/industry/new-insights-on-inflammation-promoting-heart-disease-study/88490543

A new study has found that bone marrow factors lead to increased production of white blood cells that drive inflammation in cardiovascular disease.

In patients with heart disease, white blood cells are more numerous, said senior author of the study.

Many of these cells can be found in a plaque- the buildup of fats, cholesterol and other substances in a blood vessel- where they arrive after being born in the bone marrow and migrating through the bloodstream. But what leads to their increased bone marrow output is not clear, the Dr. added.

Through experiments conducted in human bone marrow and mice, the researchers found that high blood pressure, atherosclerosis, and the occurrences of a heart attack each can cause changes in the number of blood vessels in the bone marrow. These hallmarks of cardiovascular disease also changed the bone marrow vessels’ structure and function and affected their release of factors that regulate white blood cell production and migration.

As a consequence, more white blood cells were available in the body, and this increase, called leukocytosis, propels inflammation everywhere, including in the arteries and the heart, explained the Dr.

This study will allow us to now examine how to reduce white blood cell production to normal values, thereby cooling off inflamed plaques anywhere in the body, the Dr. added.

This study provides strong evidence that cardiovascular disease affects the bone marrow vasculature and consequently blood stem cell activity said a researcher.

This work sheds new light on the important role played by the vascular bone marrow niche and how inflammation

occurs. It could lead to new targets and treatments for heart disease, the leading cause of death, the researcher concluded.

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