Asthma: just believing an odor is harmful 'could trigger airway inflammation'

For many individuals with asthma, exposure to some odors - such as perfume - can increase inflammation of the airways. But according to a new study by researchers from the Monell Chemical Senses Center in Philadelphia, PA, just believing an odor will cause harm, even if it contains no irritants, can have the same effect.

Asthma- a chronic lung disease characterized by inflammation and narrowing of the airways - affects more than 25 million people in the US. Symptoms of the disease include coughing, wheezing, shortness of breath and chest tightness.

Because the airways of asthmatics are sensitive, symptoms can be caused by certain "triggers," including dust, pollen, allergens and chemical irritants.

According to Jaén and colleagues, many health organizations cite that certain scents and fragrances - such as perfume or hairspray - can trigger symptoms of asthma. They note that this can cause patients to worry that their asthma will flare up when they are exposed to such odors.

The team wanted to determine whether anxiety surrounding exposure to odors may contribute to the development of asthma symptoms.

'It's not just what you smell, but also what you think you smell'

For their study, the researchers enrolled 17 participants with moderate asthma and exposed them to an odorant called phenylethyl alcohol (PEA) for 15 minutes.

According to the researchers, PEA has a rose fragrance and is a deemed a "pure" odorant that has no physiological irritant elements.

Before PEA exposure, eight of the participants were told that the odor may have therapeutic properties, while the remaining nine participants were told that the odor could cause mild respiratory issues.

The team found that the participants who were told that PEA exposure could be harmful rated the odor as being more irritating, compared with those who were told it could be therapeutic.

Furthermore, participants who believed the odor could cause harm experienced immediate airway inflammation, and to the team's surprise, this inflammation remained 24 hours later. No such inflammation was found among participants who believed the odor may be therapeutic.
 
The researchers believe their findings indicate that the effects of fragrances on asthma may be related to the expectation that the odor can cause harm, rather than the odor itself.

Jaén says:

"It's not just what you smell, but also what you think you smell. Asthmatics often are anxious about scents and fragrances. When we expect that an odor is harmful, our bodies react as if that odor is indeed harmful. Both patients and care providers need to understand how expectations about odors can influence symptoms of the disease."

The team says they now want to investigate the biological mechanisms underlying the association between harmful odor expectation and airway inflammation. In addition, they want to see whether reducing anxiety surrounding odor exposure among asthmatics could improve symptoms.
Earlier this year, Medical News Today reported on a study published in the journal Clinical & Experimental Immunology, which suggested that reduced exposure to "healthy microbes" in rural environments could increase the risk of asthma and allergies.

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Dogs can sniff out ovarian cancer: Study

Woman's best friend! Researchers have trained dogs to sniff out the signature chemical compound that indicates the presence of ovarian cancer with 100 % accuracy.

Ohlin Frank, a trained chocolate Labrador has been able to detect ovarian cancer tissue 100 % of the time, researchers said.

Frank and its fellow trainee, McBaine Chamberlain, a spunky springer spaniel, are a part of an interdisciplinary research project at the University of Pennsylvania to help scientists discover a chemical footprint that might lead to earlier diagnostic tests to save human lives.

They are among 15 carefully bred detection dogs learning to sniff out explosives, drugs and missing people. Researchers are using the keen sense of smell of the dogs to identify the earliest odour of ovarian cancer, a silent killer often diagnosed too late.

Cancer cells leave a detectable biomarker, just as asparagus can affect the smell of urine when eaten.

A researcher hopes the dogs can be trained to narrow down a specific odour within two years, so scientists can design an inexpensive and less-invasive blood test to catch ovarian cancer while it's still treatable.

"All dogs are really good at sniffing, but part of what gives them a huge advantage over us is the surface area of the olfactory receptors," he said.

The dogs have already been introduced to the cancer tissue smell and were taught to sit when they found it.

His work builds on a 2010 Swedish study, which used pet giant schnauzers to detect ovarian cancer. Tissue tests showed sensitivity of 100 per cent and specificity of 95 per cent; blood tests showed sensitivity of 100 per cent and specificity of 98 per cent, the report said. Dogs with long noses have the largest surface areas of olfactory receptors, said researchers. 

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