Monday, September 28, 2026

Heart disease striking Indians decades early: Doctors flag diet, stress, pollution and genetics

Heart disease is increasingly being detected among younger Indians, with doctors pointing to a combination of genetic vulnerability, unhealthy diets, smoking, sedentary lifestyles, chronic stress and air pollution as major factors driving cardiovascular risk decades earlier than in the past.

Dr Sanjay Chugh, Director, Cardiology at Aakash Healthcare, said doctors are witnessing not only a rise in heart disease but also its earlier onset.

“We are not just seeing more heart disease – we are seeing it arrive decades ahead of schedule,” Chugh said.

He attributed the trend to a combination of unhealthy eating habits, or what he referred to as “Tamasik Bhojan”, smoking and alcohol consumption, lack of exercise, chronic stress, environmental pollution including air pollution exposure, and an underlying genetic or family vulnerability.

According to Chugh, Indian populations are more prone to metabolic syndrome X and coronary disease, including heart attacks, compared with Western populations.

“This is not a problem we can treat our way out of once patients are already on the table,” he said, stressing the need for preventive healthcare much earlier in life.

“We need people walking into a hospital or clinic in their 20s asking for a heart check-up the same way they would ask for an eye test. That is the culture shift India actually needs,” Chugh said.

Dr LK Jha, Associate Director and Head Unit-II, Cardiology at Asian Hospital, also identified genetics as a key factor while pointing to lifestyle changes behind the rise in cardiovascular disease among younger people.

“Genetics is a key factor. In addition, due to various lifestyle factors, we are seeing a rise in cardiovascular diseases even among the youth,” Jha said.

He said Indians tend to have lower levels of protective HDL cholesterol, higher rates of type 2 diabetes, more abdominal fat and a greater tendency towards high blood pressure compared with Western populations.

Jha said this underlying vulnerability is now interacting with changing food habits, including greater consumption of packaged foods and trans-fat-heavy street food, which he said increases cardiovascular risk.

Smoking is adding to the burden among younger Indians, he said, particularly with the growing use of vapes and flavoured tobacco.

According to Jha, smoking damages the lining of blood vessels and accelerates the narrowing process associated with cardiovascular disease, contributing to its appearance at younger ages.

Dr Rajendra Patil, Consultant – Cardiology at Jupiter Hospital, also warned about the role of trans fats in cardiovascular disease.

“Trans fats in particular are strongly linked to heart attacks and strokes,” Patil said, adding that many people consuming such foods several times a day may not know what their food contains.

He also pointed to increasingly sedentary routines as another contributor to the problem. Long commutes, desk-based jobs and screen-heavy leisure activities have reduced physical activity among millions of young Indians, including people who consider themselves otherwise healthy.

The concerns, doctors said, extend beyond cardiology, with chronic stress, poor sleep, inactivity and pollution affecting other areas of health and potentially appearing as early warning signs of cardiovascular problems.

Dr Vineet Malhotra, Head of Urology at VNA Hospital, said he is seeing more men in their late 20s and early 30s with erectile dysfunction linked to early vascular disease.

“The blood vessels involved in sexual function and the ones feeding the heart are built the same way,” Malhotra said.

“When a young man comes to us with this complaint, we don't just treat the symptom. We send him for a cardiac workup, because often this is the first sign, not the heart attack itself,” he added.

For women, Dr Archana Dhawan Bajaj, Founder and Director of The Nurture IVF Centre and a gynaecologist, said cardiovascular risk can be harder to identify because heart disease in women is frequently missed.

She noted that symptoms can present differently in women and that public awareness around heart disease remains disproportionately focused on men.

Bajaj also pointed to the sharp rise in polycystic ovary syndrome (PCOS) among young urban women, saying it could leave a section of the population accumulating cardiovascular risk without adequate screening.

Across specialities, the doctors' recommendations converge on shifting the focus from treating established heart disease to identifying cardiovascular risk earlier.

They advocate cholesterol and blood pressure checks from the 20s rather than waiting until the 40s, greater attention to chronic workplace stress, and recognition of air pollution as a cardiovascular concern in addition to its established respiratory impact.

Dr Praveen Gupta, Chairman - Marengo Asia International Institute of Neuro and Spine (MAIINS), Marengo Asia Hospitals said "People generally believe heart disease and brain disease are two separate conversations. However, it is important to understand that they share the same blood vessels. When we see arteries narrowing in someone's heart in their early 30s, the same process is quietly happening in the vessels feeding the brain -- it is just less visible until something goes wrong.

However, it may not announce itself as dramatically as a heart attack. It can show up first as brain fog, poor concentration, or unexplained fatigue -- symptoms young professionals often brush off as burnout or stress. Apart from stress, poor sleep and sedentary habits also have a silent impact on the brain's blood supply, one that builds up quietly over years without any visible symptom. We are increasingly asking patients about their cardiac history when they come in with cognitive complaints, because the two are far more connected than people realise. Chronic stress, disrupted sleep, high blood pressure -- these don't just strain the heart, they strain the brain's blood supply too. By the time someone actually has a cardiac event, in many cases their brain has already been under silent stress for years."

 

 

 

This is only for your information, kindly take the advice of your doctor for food, medicines, exercises and so on.   

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Wednesday, July 15, 2026

How to Treat Therapy-Resistant Depression

 Everyone feels low from time to time. That is simply part of being human. Depression is something else entirely: a heavy, persistent state that drains energy, interest and hope, and that can quietly damage work, family life and friendships. The good news is that most people who seek help do get better, usually with a combination of medication and talk therapy. But there is a group of people for whom the first, second or even third attempt at treatment simply does not work. If that describes you or someone you love, the situation may feel hopeless. It is not.

Depression that fails to improve after two adequate trials of antidepressants from different drug families has a name: treatment-resistant depression. The name sounds like a dead end, but in practice it is closer to a signpost. It tells doctors that the standard route has not worked and that it is time to look at the problem from a different angle. Here is what that means, why it happens, and what can be done about it. 

How common is it? 

More common than most people realize. Roughly one in three people with major depression does not get meaningful relief from standard antidepressants, and many others improve only partially, which can be almost as frustrating. Feeling somewhat better but never truly well is a very common experience, and it deserves the same attention as no improvement at all.

Before you accept the label, check the basics 

There is no single laboratory test that confirms treatment-resistant depression. Doctors reach the conclusion by working through the alternatives first, and that step matters enormously, because a surprising number of apparent treatment failures turn out to be something else. A careful clinician will want to know: 

Was the original diagnosis correct? Several conditions can look very much like depression from the outside, including bipolar disorder, an underactive thyroid, anemia, sleep apnea, chronic pain and the side effects of other medications. Treating the wrong target rarely works. 

Was the dose high enough? Antidepressants are often started low and gently increased. If the dose never reached a therapeutic level, the medication was not really given a fair trial. 

Was it taken consistently? Missed doses, stopping when side effects appear, or restarting a week later all blunt the effect. This is very common and nothing to be embarrassed about, but it needs to be said out loud to the doctor.

Was it given enough time?
Antidepressants are slow. Six to eight weeks at a proper dose is usually needed to judge the full effect. Interestingly, people who notice at least a small shift within the first two weeks are more likely to end up with a strong response later on. Someone who feels nothing at all early on is less likely to improve dramatically down the line, which is useful information for planning the next step rather than a reason to give up. 

Is something working against the treatment? Heavy alcohol use, ongoing insomnia, an untreated anxiety disorder or a difficult life situation that will not budge can all keep a person stuck no matter how good the prescription is.

Why do some people not respond? Researchers do not have a complete answer, but several explanations are being actively explored. 

Hidden bipolar disorder. One of the oldest theories is that a portion of people labeled treatment resistant actually have bipolar disorder, where the depressive episodes look identical but respond to a completely different set of medications. A history of periods of unusually high energy, reduced need for sleep or impulsive decisions is worth mentioning to your doctor.

Genetics
. Inherited differences affect how quickly the body breaks down a medication and how strongly the brain responds to it. Someone who metabolizes a drug very fast may never reach a useful level in the bloodstream even at a normal dose. Genetic testing that helps predict which antidepressants are most likely to suit a particular person now exists, though it is still a guide rather than a crystal ball. 

 Body chemistry and nutrients. Some studies have found unusually low levels of folate in the fluid surrounding the brain and spinal cord in people who do not respond to treatment. Deficiencies in vitamin D, vitamin B12 and iron can also drag mood down and are easy to check with a blood test.

Inflammation. A growing body of research links chronic low grade inflammation with depression that resists standard treatment, which may help explain why depression so often travels alongside conditions like heart disease and diabetes. 

Trying a different medication approach 

If a first antidepressant did not help, the usual next move is to switch to one that works through a different mechanism. Antidepressants are grouped into families, and jumping to a different family gives the brain a genuinely different signal rather than more of the same. The main families include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, norepinephrine and dopamine reuptake inhibitors, tricyclics, and the older monoamine oxidase inhibitors, which are used less often today but can be remarkably effective in stubborn cases.

Two antidepressants are sometimes prescribed together when one alone falls short. Doctors also frequently reach for what is known as augmentation, meaning a second medication that is not itself an antidepressant but boosts the one you are already taking. Lithium, low doses of certain antipsychotic medications and thyroid hormone are the classic examples, and all three have decades of evidence behind them. 

The rapid acting options 

The biggest change in depression treatment in a generation has come from medications that act on glutamate, a brain messenger that traditional antidepressants largely ignore. Esketamine, a nasal spray derived from ketamine, is approved specifically for treatment-resistant depression and is given in a clinic under supervision alongside an oral antidepressant. Unlike older drugs, it can lift symptoms within hours or days rather than weeks, which makes it especially valuable for people in crisis. Intravenous ketamine is used in a similar way in some clinics. An oral combination of dextromethorphan and bupropion works on related pathways and is another relatively new option.

These treatments require monitoring, they are not suitable for everyone, and cost and insurance coverage can be a real obstacle. But for people who have cycled through medication after medication, they represent a genuine change in what is possible. 

Talk therapy still matters
Medication is not the only tool, and people who respond poorly to pills sometimes respond very well to structured therapy. Cognitive behavioral therapy, which teaches practical ways to identify and interrupt the thought patterns that feed depression, has been shown to improve symptoms in people whose medication did not do the job. Most of the research looked at therapy combined with medication rather than therapy instead of it, so this is usually an addition to the plan and not a replacement.

Brain stimulation treatments  

When medications and therapy are not enough, treatments that act directly on brain activity come into play. 

Transcranial magnetic stimulation. A magnetic coil placed against the scalp delivers pulses to a specific area of the brain involved in mood regulation. It is done in a clinic, requires no anesthesia, and the person stays awake and goes home afterward. The standard course runs daily over several weeks, though accelerated protocols that compress treatment into a few days are increasingly available.

Electroconvulsive therapy. ECT has an unfortunate reputation built on films from another era. The modern version is performed under general anesthesia with muscle relaxants, and it remains one of the most effective treatments available for severe depression. It is generally reserved for serious cases, partly because of cost and partly because it requires anesthesia, and it can cause temporary memory problems. For people who have run out of other options, it can be genuinely life saving.

Vagus nerve stimulation. A small implanted device sends mild electrical pulses along a nerve that carries signals to mood regulating areas of the brain. It works slowly, over months rather than weeks. 

Deep brain stimulation remains experimental for depression and is available mostly through research settings. 

What about stimulants? 

There has been considerable interest in adding stimulant medications to antidepressants, and the results are genuinely mixed. Studies of methylphenidate, modafinil and lisdexamfetamine have generally failed to show a benefit for depression overall. What they did show is improvement in specific symptoms, particularly fatigue and daytime tiredness. That makes stimulants a reasonable option for a narrower group of people: those whose exhaustion refuses to lift even when the rest of the depression improves, and those who have attention deficit hyperactivity disorder alongside depression. As a general treatment for depression, the evidence does not support them.

The things you can do yourself 

None of these replace medical treatment, but they meaningfully improve the odds that treatment will work. Regular physical activity has real antidepressant effects, and even a daily walk counts. Protecting sleep, getting outdoors in daylight, cutting back on alcohol and staying connected to other people all push in the right direction. Keeping a simple written record of your mood, sleep, medication and side effects is also worth its weight in gold, because it turns vague impressions into information your doctor can actually use. 

The outlook 

Treatment-resistant depression is difficult, but the name is misleading. It does not mean untreatable. It means the standard route has not worked and a different one is needed, and there are now more of those routes than at any point in the past. Finding the right one takes patience, persistence and a doctor who will keep working the problem with you rather than shrugging and repeating the same prescription. 

In the meantime, do not carry it alone. Support groups, whether in person or online, connect you with people who have been through the same maze and can tell you what helped them. Depression is very good at whispering that nothing will ever change. It is a persuasive liar, and the evidence is against it. 

 If you or someone close to you is struggling, please speak to a doctor or mental health professional. If you are having thoughts of harming yourself, seek help immediately from a local emergency service or crisis line.


This is only for your information, kindly take the advice of your doctor for food, medicines, exercises and so on.   


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