Easier detection of concussions!

According to a study some specific small molecules in blood plasma may be useful in determining whether someone has sustained a mild traumatic brain injury (mTBI), commonly known as a concussion.

Six specific small molecules from blood plasma were discovered in a group of college athletes who had been diagnosed with concussions. When these molecules were assessed, their combined presence accurately predicted whether teammates had sustained an mTBI or not.

This suggests that these small molecules, and possibly others, might be clinically relevant biomarkers of mTBI.

The same six biomarkers were then tested in a separate group of individuals, without and with mTBI, and the results replicated the athlete findings.

Although the results are encouraging, the authors reported limitations to their study and recommended additional investigations related to these and other mTBI biomarkers in blood that will further clarify their utility in clinical management.

“Such blood tests are important in determining not only whether someone has sustained a concussion, which is not currently an easy task, but may eventually prove useful in defining when injured individuals may be eligible to safely return to regular activities,” said  the paper’s first author.

Researchers are helping advance technologies and therapeutic approaches that may benefit all societies, but are directly relevant to their local populations.

The estimated 40 million individuals worldwide diagnosed with mTBI likely represent a gross underestimation of those actually sustaining such injuries.

Clinical practitioners require a relevant and reliable, minimally invasive, objective diagnostic test to determine high versus low probability of mTBI in a timely manner.

The author said there is a clear need to improve diagnostic capabilities, which could reduce under-reporting of mTBI and allow more appropriate care to be delivered to concussed individuals.

Although current technologies for defining the discovered small molecules in today’s publication lack the rapid, point-of-care platforms being developed for other measures, the study authors anticipated a growing technological momentum to develop such novel platforms resulting from this and similar investigations.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/  

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                              https:// kneereplacement-stickclub.blogspot.com/                              
FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://my crochet creations.blogspot.com  

Diagnostic tests for nut allergy may be 'unreliable', say scientists

Scientists have deemed nut allergy tests inaccurate, saying that an allergy from one type of nut doesn't determine your sensitivity to all other nuts.
 
The scientists have further claimed that certain diagnostic tests may be unreliable.

Researchers from American College of Allergy, Asthma and Immunology (ACAAI) in the US examined records of about 109 people with a known tree nut allergy to an individual nut.

They were then tested for other tree nuts they had never eaten before using blood or skin prick tests.

Researchers found that among people allergic to one nut who have a positive test to other tree nuts, more than half passed an oral food challenge to other tree nuts without a reaction.

"Too often, people are told they're allergic to tree nuts based on a blood or skin prick test," said Christopher Couch of ACAAI.

"They take the results at face value and stop eating all tree nuts when they might not actually be allergic. Despite showing a sensitivity to the additional tree nuts, more than 50 percent of those tested had no reaction in an oral food challenge," Couch said.

At present, the most accurate way to diagnose a possible food allergy is an oral food challenge, during which, the patient eats tiny amounts of the food in increasing doses over a period of time, followed by a few hours of observation to see if they have a reaction.

"An oral food challenge should only be conducted under the care of a trained, board-certified allergist. You should never do one on your own since if you are allergic, you could have a severe, life-threatening reaction," researchers said.

Tree nuts include almonds, cashews, walnuts and hazelnuts, but not peanuts. The study noted that nearly none of the people allergic to peanut, but sensitised to tree nut, were clinically allergic to tree nut.

The study was published in the journal Annals of Allergy, Asthma and Immunology.

 this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.

https://gscrochetdesigns.blogspot.com. one can see my crochet creations
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes 
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement

Skin patches may replace blood diagnostic test

Scientists have, for the first time, designed and successfully tested a small skin patch that detected malaria proteins in live mice and could replace the traditional blood diagnostic test.

Drawing blood and testing it is standard practise for many medical diagnostics. As a less painful alternative, scientists are developing skin patches that could one day replace the syringe.

In the The American Chemical Society (ACS)'s journal Analytical Chemistry, a team of researchers report they have designed and successfully tested, for the first time, a small skin patch that detected malaria proteins in live mice.

It could someday be adapted for use in humans to diagnose other diseases, too, researchers said.
Simon R Corrie and colleagues note that while blood is rich with molecular clues that tell a story about a person's health, withdrawing it is often painful.

It also requires trained personnel and expensive lab equipment and facilities for analysis. These factors don't lend themselves to patient compliance or accessibility in resource-limited places.

Scientists have been trying to address these hurdles by developing diagnostic patches that are covered on one side with thousands of microscopic, hollow needles that can sample fluid in the skin.

But so far, these devices have only been able to test for one compound at a time. However, many diseases can be diagnosed more reliably by detecting multiple bio-markers. Corrie's team wanted to design a new patch that could meet this need.

The researchers optimised their device so it could capture two bio-markers for the malaria parasite, Plasmodium falciparum, which kills more than 1 million people every year.

To test it, they injected malaria proteins into the bloodstream of live mice and applied the patch to their skin. The patch successfully captured the proteins in the skin tissue.

Such devices, they conclude, could be used in the future to diagnose malaria and other infectious diseases in a less painful way.

 THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.








PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-

HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/

FOR CROCHET DESIGNS

HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM