Saturday, February 02, 2019

How Your Body Reacts When Temperatures Drop

The human body uses some pretty incredible mechanisms to try to stay warm, whenever temperatures drop below freezing. Here are 10 weird things that happen to your body when it's freezing:
1. Your blood vessels constrict
Your body is built to maintain a stable temperature of 98.6 degrees Fahrenheit, or 37 degrees Celsius. But, what happens to your body when a temperature in your environment drops to freezing cold? Thermo-receptors in your skin sound the alarm, alerting an area of the brain called the hypothalamus. This area of the brain acts like a thermostat that's job is to maintain steady body temperature. So, when it's too cold, the hypothalamus tightens the blood vessels in your arms, hands, feet, and legs. Blood delivers heat to the skin, so if you decrease blood flow to the skin, you decrease heat loss from the skin. 

2. You can become too cold if you dress too warmly
As ironic as this scenario might sound if you're outside in cold weather shoveling snow, this amount of physical work will cause your muscles to contract, generating a lot of heat, causing your core temperature to go up. According to a research physiologist “In this situation, your blood vessels dilate instead of constrict, and you start sweating. If that sweat then gets trapped in your clothing, then it can start sucking heat away from your body. That’s a recipe for hypothermia right there.”
3. You have to urinate
Here's an irritating scenario: You use the bathroom, right before you head outdoors, but feel the need to go again soon after being outside. This happens because all that vasoconstriction (the constriction of blood vessels) forces fluid to concentrate in your core. This causes volume receptors to communicate with the hypothalamus, letting it know that it should get rid of some of that fluid, thus causing you to pee. 

4. You have trouble catching your breath
When you inhale air, your nose moistens, humidifies and warms it before moving down to the lungs. But for people who suffer from asthma, or where the weather is bitter cold, the air doesn't warm enough first, causing the lungs to spasm and constrict, making breathing difficult. 
5. You scrunch down and huddle with others
When your blood vessels have been constricted, this causes your muscles to start to shiver, making you instinctually engage in social behaviors that help conserve heat. So when you scrunch down and make yourself smaller, you lose less heat to the environment. This happens because you decrease your own surface area. 
6. You shiver
While you do shiver when it's cold, the reason you do so is pretty interesting.A Prof. says “When vasoconstriction isn’t doing enough to warm you, the hypothalamus tells your muscles to start contracting. One of the byproducts of muscle contraction is heat.” If you get cold enough to enter into mild hypothermia, you can produce 400 to 600 watts of heat through shivering. 
7. Your muscles tense
The Prof. explains that as muscle tissue cools, it doesn't work as well. “At first, you lose the ability to do fine motor tasks, like using your cell phone correctly,” he says. “Then eventually as your bigger muscle groups are affected, you might not, say, be able to hold on to an overturned boat in cold waters.”


8. You freeze much faster if wet
Do you notice how little kids shiver when they get out of a heated swimming pool in 80-degree weather? the Prof. says, “Water carries heat away from the body 25 times faster than air, so you can lose a great amount of heat very quickly when you’re wet. Shivering is one way your body is trying to raise your core temperature back up.” 
9. Your skin turns white and hard
These are signs of frostbite, a condition that arises when you expose your skin to cold and freezing temperatures. Your cheeks, nose, and fingers tend to be especially vulnerable because they are getting less blood flow due to the vasoconstriction effect. Because of the shape of your fingers, it gives them more surface area relative to their size, making them more vulnerable to heat loss. Frostbite means the skin tissue has become damaged, and if severe enough, it can turn black and actually fall off. You begin to feel pain as your skin gets colder and colder, but soon, it will feel numb. And when this happens, the thermoreceptors in your skin have stopped working. 
10. You make things worse if you drink alcohol
If you think that a flask of whiskey will keep you toasty, you are dead wrong. The body's first major reaction to cold is to constrict the blood vessels. However, “alcohol does the opposite—it causes peripheral vasodilation,” explains the Prof. “Those blood vessels widen and dump all this heat to the environment.” So, what happens here is that your skin will feel warm, but that provides a false sense of security, because, in reality, your core temperature drops, leading to extreme hypothermia. 
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Sunday, December 16, 2018

High blood pressure before age 40 linked to higher risk of cardiovascular disease

New  research has found that younger adults with high blood pressure before the age of 40 have an increased risk of cardiovascular events such as heart failure, strokes and blood vessel blockages as they age.

The study used the new blood pressure guidelines issued in 2017, which lowered the clinical definition of high blood pressure from earlier levels, to investigate the association between level of blood pressure (BP) in young adulthood and the risk of cardiovascular disease (CVD) by middle age.

Participants included 4,851 young adults aged 18 to 30 years who had blood pressure measurements taken before age 40 as part of the Coronary Artery Risk Development study  which began in 1985. 

Participants were then categorised into four groups based on their blood pressure levels: Normal (120 or lower systolic blood pressure over 80 diastolic or less); elevated (120-129 over less than 80); stage 1 hypertension (130-139 over 80-89); or stage 2 hypertension (140 or greater over 90 or greater). 
The researchers looked at participants’ data over a median of 18.8 years.

The findings,  showed that participants with elevated blood pressure, stage 1 hypertension, and stage 2 hypertension before age 40, as defined by the 2017 guidelines, had a significantly higher risk of cardiovascular disease events compared with those with normal blood pressure before the age of 40.

"This is a first step in assessing whether high blood pressure, as defined by the new criteria, is something that younger people should be concerned about as a potential precursor to serious problems," commented lead author. "Although this is an observational study, it demonstrates that the new blood pressure guidelines are helpful in identifying those who might be at risk for cardiovascular events."

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Sunday, May 10, 2015

Young prostate cancer patients suffer more hot flashes

Men who are younger or have a lower body mass index (BMI) are more prone to experience hot flashes during a common treatment for patients with advanced stage prostate cancer, a new research has found.

More than 25 percent of prostate cancer patients report that hot flashes are the most distressing side effect of androgen deprivation therapy (ADT).

"This study is a concrete step towards identifying which patients are more likely to experience these distressing symptoms," said Mayer Fishman from the Moffitt Cancer Center in Florida, US.
The researchers also reported that the presence of certain genes involved in processes such as immune function, nerve impulse transmission, blood vessel constriction and circadian rhythms were associated with an increased number of hot flashes.

They compared 60 prostate cancer patients on ADT to 83 prostate cancer patients who did not have ADT and 86 men without cancer.
They discovered that patients on ADT experienced significantly more hot flashes at six months and 12 months after therapy initiation than the other two control groups combined.

The severity of the hot flashes also increased over time in the group of men receiving ADT.

The patients reported that the hot flashes interfered with their daily lives by affecting leisure activities, sleep and general quality of life.
The researchers analysed patient characteristics and their DNA to determine which factors were associated with an increase of hot flashes.

The study appeared in The Journal of Urology. 


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