Tuesday, August 25, 2020

What exactly does COVID-19 do to your lungs?

COVID-19, short for coronavirus disease 2019, is a new illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There has been a lot of discussion about the symptoms of COVID-19, but not much is known about the condition after a patient has recovered from the illness. Perhaps, there’s little information available on whether COVID-19 can cause any permanent or long-term effects on the body, especially the lungs.

Early symptoms of COVID-19

The infection starts off with mild flu-like symptoms or no symptoms and further progresses to severe symptoms. Initially, COVID-19 infects the lung in the affected individual and, in severe cases, causes death due to ARDS (acute respiratory distress syndrome) and pneumonia. However, it is important to remember that COVID-19 does not lead to ARDS and pneumonia in all cases.

Worldwide, it has been observed that most people (about 80 per cent of total cases) infected with coronavirus will exhibit mild symptoms, 13 per cent will have pneumonia, 5 per cent will suffer from septic shock and organ failure (mostly respiratory failure) and 2 per cent of cases may result in fatality.

Some of the primary symptoms to look for in COVID-19 patients are fever, breathing problems, headache, dry cough (eventually results in phlegm) and in a few cases it may cause loss of smell and taste. Some patients could experience diarrhea and fatigue as primary symptoms.

COVID-19 primarily affects your lungs

The lung is the organ which is most commonly affected by COVID-19 and can result in a spectrum of adverse effects. However, the SARS-CoV-2 virus can cause devastating effects on your other organs, including the heart and blood vessels, brain, kidneys, liver, immune system, stomach and intestines - and not just the lungs.

“In case of pneumonia, the infection causes initial damage (inflammation) to the small air sacs present in the lungs and makes the lungs to be filled with fluid/puss, making it hard for the patients to breathe. If a large percentage of the lungs is affected, people struggle to absorb enough oxygen and are admitted to hospital with severe difficulty in breathing,” said Dr Govini Balasubramani, Senior Consultant - Cardiothoracic Surgery, Heart & Lung Transplantation, Gleneagles Global Health City, Chennai.

According to Dr Balasubramani, another severe complication is acute respiratory distress syndrome (ARDS) - also known as “wet lung”. This occurs due to the infection spreading quickly throughout the lungs. People who develop this condition may need assisted breathing i.e. mechanical ventilation in an intensive care unit. In some cases, the patient may also require a ventilator for a prolonged period of time. COVID-19 also causes marked clotting in the small blood vessels of the lungs as well as other organs.

Does COVID-19 have long-term effects on the lungs?

While the lungs can recover from severe COVID-19 disease, they can sustain long-term damage by leaving a scar behind.

“The SARS-CoV-2 virus enters the cells of the airway through angiotensin-converting enzyme receptor, a molecule that connects the inside of our cells to the outside via the cell membrane. When this happens, an intense immune response, known as cytokine storm occurs, along with increased blood clotting, all of which leads to damage of lung cells. The body replaces the cells damaged by the virus with scar tissue, which is thick and rigid. This can result in a condition called “pulmonary fibrosis”, which is mostly seen in people diagnosed with COVID-19. This condition is probably more likely to develop if the lungs are severely affected by the infection. The condition can make people experience breathlessness while doing routine activities that they would otherwise manage easily without any difficulty. Drugs that reduce scarring could help in preventing this complication,” added Dr Balasubramani.

Health experts are yet to better understand the impact of pulmonary fibrosis, but they believe that it may lead to long-term symptoms and a progressive fall in lung function that can be diagnosed by a pulmonary function test. Hence, follow-up care of these patients for deteriorating lung function is very important.

Follow-up care for COVID-19 patients

Available data shows that SARS can cause pulmonary fibrosis and a large analysis of SARS and MERS patients showed weakened lung function in some survivors up to six months after hospital discharge. However, 15 years follow-up of such patients showed improvement in lung function and less damage visible on CT scans over time. According to earlier studies done on people who were recovering from COVID-19, lung condition improves in the first few weeks after getting discharged from the hospital.

People who are getting treated for the disease may have an impact on their general fitness. Furthermore, those who underwent mechanical ventilation for a long time may lose a significant degree of muscle mass, leaving them weak even after their lungs have recovered.

People who are vulnerable to the infection especially older adults can become destabilised even after suffering from “mild” COVID-19. This may impact their ability to live independently, so it has important implications on the demand for social care services and pulmonary rehabilitation.

While the vast majority who contract with COVID-19 will recover completely, we’re likely to see more people with pulmonary fibrosis or persistent lung damage suffering from ARDS caused by COVID-19. These patients may need antifibrotics (after research data availability), home oxygen therapy, pulmonary rehabilitation, and regular follow-ups. Meeting such people’s long-term healthcare needs will pose a significant challenge.

Coronavirus can affect anyone, however, people with underlying conditions are more likely to have severe symptoms than those who don't have a medical condition that increases their risk. If you're particularly at risk due to a lung condition or other serious health issue, take extra precautions to reduce your risk and stay safe.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement

 


 

 

 

Labels: , , , , , , ,

Friday, June 12, 2020

Study discovers inhibition of SARS-CoV-2 entry priming protein by approved drug

The COVID-19 pandemic caused by the severe acute respiratory syndrome -coronavirus 2 (SARS-CoV-2) has spread to most of the world, causing millions of cases and hundreds of thousands of deaths. A new study published on the preprint server bioRxiv* shows that a protease inhibitor drug already approved by the Food and Drug Administration (FDA) could inhibit viral entry.

What is TMPRSS2?

The SARS-CoV-2 enters the host cell via the angiotensin-converting enzyme 2 (ACE2) receptor, to which it attaches via the spike (S) protein on the virus envelope. Another host protein called transmembrane protein serine protease TMPRSS2 also plays a vital role in processing the S protein and receptor. This is necessary for further interaction of the S protein and ACE2 receptor leading to infection.

When the TMPRSS2 protein is blocked by a molecule called camostat mesylate, the virus cannot enter the host cell. This offers a promising avenue for the therapy of this infection.

TMPRSS2 plays a role in several coronavirus infections, such as the earlier SARS, MERS and the current SARS-CoV-2, and also some influenza infections. It is also important biologically as a prostate cancer oncogene.

It is a promising antiviral drug target because it is a host protein. Drugs that are designed to fit viral proteins are always subject to the risk of becoming obsolete due to the high rate of viral genomic mutations that can change the protein characteristics. However, agents that are directed against host proteins are less likely to counter rapid drug resistance.

This type of drug does carry one risk, however. This is the risk that alterations in the protein pathway involved will also cause undesirable changes in the host physiology.

Researchers have been concerned that TMPRSS2 is the starting point for a series of amplifying proteolytic activation events. These are important in regulating seminal fluid and lung proteins since TMPRSS2 is a sodium channel regulator.

However, mouse experiments in which the mice lack this protein do not show any apparent deficits. Scientists hope that this means other proteases can replace the protein with respect to its function.
This could mean it is safe to target TMPRSS2 during viral infections. Moreover, there are already approved drugs that act to inhibit the proteolytic activity of this enzyme, such as camostat mesylate, nafamostat, and BHH.

How was the study done?

The researchers did a functional screening to find TMPRSS2 inhibitors and compared their efficiency. The tested molecules include secretory leukocyte peptidase inhibitor (SLPI), 4-(2-aminomethyl) benzenesulfonyl fluoride (AEBSF), Boc-Gln-Ala-Arg-7-Amino-4-methylcoumarin (BOC-QAR-AMC), camostat mesylate, bromhexine hydrochloride (BHH) and alpha 1 antitrypsin (A1AT).

They used a human cell line in which TMPRSS2 was expressed at very high levels, at 2.5 times that of control cells. The rate of proteolysis was increased over 3.5 fold compared to that of controls and remained more than double after hours.

What did the study show?

The researchers used camostat mesylate, a known TMPRSS2 inhibitor, in control cells. At concentrations as low as 100 nM, it showed inhibitory action.

Next, they tested for the inhibitory action of SLPI, at various concentrations, without success. However, A1AT showed dose-dependent inhibition of the proteolysis induced by TMPRSS2 with the highest effects at a concentration of 1 μM.

With AEBSF, a protease inhibitor capable of inhibiting influenza infection in a murine experiment, dose-dependent inhibition of TMPRSS2 occurred with a peak at 1 μM.

BHH is an FDA-approved drug used as a mucolytic and cough suppressant, which inhibits TMPRSS2 in a dose-dependent manner, but is less efficient than A1AT or AEBSF.

What do the findings imply?

In the current study, the researchers shortlisted two novel inhibitor molecules, namely, AEBSF and A1AT. It is possible that these inhibitors could potentially block viral activity by preventing TMPRSS2’s action on S protein processing.

A1AT is a small protein manufactured in the liver and present in the blood at high levels. It can shoot up six times in acute inflammation or injury. It is delivered to many organs when administered as a drug.

In the lungs, it blocks the action of the protease enzymes neutrophil elastase, proteinase 3, and cathepsin G. it also enhances the clearance of apoptotic cells, and so protects the body against tissue damage and overactive inflammation.

Mutations in the A1AT gene could lead to subnormal levels of the protein, causing the lung to suffer protein breakdown and widespread emphysema of the lobes. The FDA approved the use of A1AT as a replacement in cases of deficiency.

While A1AT was previously known to block H3N2 infection and influenza B virus in animal models, this is the first time that it is being shown to inhibit TMPRSS2. The earlier viruses do not need to be primed by TMPRSS2, and their blocking was presumed to be via hepsin inhibition.

The use of A1AT may reduce the disease severity in COVID-19 by dampening inflammation within the alveoli as well as inhibiting TMPRSS2. Earlier experiments have shown that the levels of truncated A1AT found in peripheral blood in SARS patients are higher than in controls, and rise in proportion to disease severity. This could mean that this protein is a component of a natural immune response against CoV infection as well as acute lung disease.

A1AT is a serine protease inhibitor (SERPIN) and thus has a reactive center loop that is broken apart by interaction with proteases. This breakage causes A1AT to undergo a conformational change, which results in irreversible covalent bonding with the target protease, inhibiting its activity permanently.

It is thought that the truncated A1AT seen in SARS patients arise from this type of cleavage caused by TMPRSS2 and other proteases.

AEBSF also blocks the activity of TMPRSS2, being a small molecule that inhibits proteases nonspecifically. It has caused a decrease in the levels of both H1N1 and H7N7 nuclear proteins within the lung tissue of mice infected with influenza. Its mechanism of action is via a covalent bonding, which adds a sulfonyl group to the active site.

The use of protease inhibitors – camostat mesylate, A1AT, BHH, and AEBSF – could help develop antivirals against COVID-19. The researchers say, “A1AT may be particularly effective as it has the dual capacity, inhibiting TMPRSS2 (and hence viral uptake and subsequent replication) and possessing anti-inflammatory activity. The ready availability of A1AT calls attention to its potential clinical use for the COVID-19 pandemic.”


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement


Labels: , , , , , , , , ,

Thursday, May 21, 2020

SARS antibody found to neutralise COVID-19 virus

An antibody first identified in a blood sample from a patient who recovered from Severe Acute Respiratory Syndrome (SARS) in 2003 has demonstrated the ability to prevent SARS-CoV-2 live virus infection of cells in the laboratory, says a study, raising new hope in the fight against COVID-19.

The antibody, called S309, is now on a fast-track development and testing path at San Francisco-headquartered Vir Biotechnology in the next step toward possible clinical trials.

The initial results, published in the journal Nature, could ultimately pave the way for using the S309 antibody, alone or in a mixture, as a preventive measure for people at high-risk of exposure to the COVID-19 coronavirus or as post-exposure therapy to limit or treat severe illness, according to the scientists.

"We still need to show that this antibody is protective in living systems, which has not yet been done," said study co-author David Veesler, Assistant Professor of Biochemistry at the University of Washington School of Medicine.

"Right now there are no approved tools or licensed therapeutics proven to fight against the coronavirus that causes COVID-19," he added.

Vir Biotechnology in a separate statement said it is advancing two clinical development candidates based on the S309 antibody as potential therapeutics for COVID-19 -- VIR-7831 and VIR-7832 -- in collaboration with GlaxoSmithKline plc.

The research showed that the S309 antibody is particularly potent at targeting and disabling the spike protein that promotes the coronavirus entry into cells.


It was able to neutralise SARS CoV-2 by engaging with a section of the spike protein near the attachment site to the host cell.

Through their cryo-electronmicroscopy studies and binding assays, the researchers learned that the S309 antibody recognises a binding site on the coronavirus that is conserved across many sarbocoviruses, not just the SARS and COVID-19 viruses.

That is probably why this antibody, instead of being single-minded, is able to act against related coronaviruses.

Combining the S309 antibody with other, though weaker, antibodies identified in the recovered SARS patient enhanced the neutralisation of the COVID-19 coronavirus, said the study.

This multiple antibody cocktail approach might help limit the coronavirus' ability to form mutants capable of escaping a single-ingredient antibody treatment, according to the researchers.

"Remarkably, we believe S309 likely covers the entire family of related coronaviruses, which suggests that, even as SARS-CoV-2 continues to evolve, it may be quite challenging for it to become resistant to the neutralizing activity of S309," Herbert "Skip" Virgin, Chief Scientific Officer, Vir, said in a statement.

"In addition, S309 exhibits potent effector function in vitro, potentially allowing the antibody to engage and recruit the rest of the immune system to kill off already infected cells."


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement

Labels: , , , , , , ,