Type 2 diabetes quietly rewires heart, raises risk of failures: Study

 Type 2 diabetes quietly changes the heart structure and how it produces energy, thus increasing the risk of heart failure, according to a study.

Researchers at the University of Sydney, Australia, studied donated human hearts and found that diabetes disrupts how heart cells produce energy, weakens the muscle’s structure, and triggers a buildup of stiff, fibrous tissue that makes it harder for the heart to pump.

These effects were most pronounced in patients with ischemic cardiomyopathy-- the leading cause of heart failure. The findings, published in the journal EMBO Molecular Medicine, can help explain why people living with diabetes face a much higher risk of developing heart failure.

"We've long seen a correlation between heart disease and type 2 diabetes, but this is the first research to jointly look at diabetes and ischemic heart disease and uncover a unique molecular profile in people with both conditions,” said Dr. Benjamin Hunter, from the School of Medical Sciences.

"Our findings show that diabetes alters how the heart produces energy, maintains its structure under stress, and contracts to pump blood. Using advanced microscopy techniques, we were able to see direct changes to the heart muscle as a result of this, in the form of a build-up of fibrous tissue," he added.

To better understand how diabetes affects the heart, the researchers studied heart tissue from both transplant recipients and healthy individuals. This direct examination allowed them to see how diabetes influences heart biology in real human patients rather than relying solely on animal models.

The results showed that diabetes is more than a co-morbidity for heart disease. It actively accelerates heart failure by interfering with essential biological processes and reshaping the heart muscle at the microscopic level. "The metabolic effect of diabetes in the heart is not fully understood in humans," said Hunter.

In healthy hearts, energy is mainly generated from fats, with glucose and ketones also contributing. Previous research has shown that glucose use increases during heart failure. However, diabetes interferes with this process by reducing how sensitive heart cells are to insulin.

 

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

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Study shows heart disease deaths surge in patients with cancer

The team studied a total of 3,79,944 participants without cardiovascular disease at baseline, including 65,047 individuals with cancer.

Patients with cancer are more likely to die from cardiovascular diseases, according to a study. The study, published in the Journal of the American Heart Association, showed that the risk may be related to altered expression of inflammation‐ and coagulation‐related proteins.

The researchers from the Chinese Academy of Medical Sciences stressed the need to manage endocrine, kidney, and inflammation‐related risk factors in people with cancer. “Our study found an elevated cardiovascular death in patients with cancer,” said the team.

“Patients with cancer need to pay attention to the risk of cardiovascular mortality, particularly among younger individuals and those diagnosed at an early stage; in clinical practice, it is recommended to emphasise the management of endocrine, kidney, and inflammation‐related risk factors in the population with cancer,” they added.

Previous studies have identified a link between cancer and cardiovascular disease; however, the underlying genetic and proteomic mechanisms remain unclear. Therefore, the new study aimed to investigate the association between cancer diagnosis and cardiovascular mortality and to explore the potential mechanisms involved.

The team studied a total of 3,79,944 participants without cardiovascular disease at baseline, including 65,047 individuals with cancer. Genome‐wide association studies, phenome‐wide association studies, and proteomic analyses were applied to investigate the underlying genetic and proteomic mechanisms.

The results revealed only a limited number of shared genetic variations between cancer and cardiovascular conditions, such as hypertension and cardiac dysrhythmias. The researchers also identified nine independent risk factors for cardiovascular death, including age, sex, smoking, BMI, systolic and diastolic blood pressure, HbA1c, cystatin C, and neutrophil count.

Interestingly, the probability of survival from CVD was comparable between participants with and without cancer during the first 10 years of follow‐up but declined more sharply thereafter among patients with cancer. This was possibly associated with the reduction in systemic tumour burden and the resolution of inflammation and coagulation disorders following treatment therapies, the team said.

 

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

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Treating Stiff and Sore Muscles

 Have you ever woken up in the morning and stretched only to feel neck or shoulder pain? Every movement afterward sends pain shooting down your back, but why exactly does this happen? Read on to find out:

Why do muscles get stiff?

 

• Muscles require magnesium for them to relax, and calcium for them to contract. When the two are imbalanced, it can lead to muscle spasms and contractions. 

 

• Dehydration is also a contributing factor to stiff muscles. This is because muscles are active tissues and require lots of water. The water contains electrolytes that help transfer orders from your nervous system to your muscles and back. Without enough water, muscles lose their ability to communicate with the brain. 

 

• Inactivity is another culprit. Leaving your muscles in one state for a prolonged period (sleep or sitting in a chair for an extended period, for instance) can cause them to stiffen. Another cause of muscle stiffness is stress. When we’re stressed, our bodies tighten up in preparation for a “fight or flight” situation. Prolonged stress can lead to tightness in the muscles, resulting in strain. 

 

• The biggest contributor to muscle pain of all is exercise. Muscles lose mass after a prolonged period of inactivity, so when you start training again, it leads to micro-tears that cause pain and stiffness. 

How to treat stiff muscles

 

1. Exercise 

 

Exercising for 30 minutes each day (or every other day) can prevent most cases of muscle stiffness. Exercise keeps your muscles relaxed, and can even improve your mental state. Just don’t overdo it, because that’s when your muscles get stiff. 

 

2. Baking soda bath  

Add 2-4 heaped tablespoons of baking soda to a hot bath and climb in for rapid muscular pain relief. You can even try replacing the baking soda with ¾ cup of Epsom salt if you wish to. 

 

3. Take supplements 

Balance your magnesium and calcium levels by taking supplements, and consider making dietary changes. 

 

4. Massage therapy 

Getting a good massage can work wonders for stiff muscles. A licensed masseuse will be able to relieve stiff muscles in a single session, sending you home pain-free and much more relaxed (consult your massage therapist regarding the best treatment for you). 

 

5. Heat application 

Simply applying heat to muscles causes the tissue to expand and increase blood flow to the heated area. You can do this by taking a hot shower or massaging the stiff area with a heating pad. 

 

6. Relax & Meditate  

Calm yourself down. By reducing the level of stress in your life, your body will relax as well, reducing the likelihood of tight and stiff muscles. 

 

7. Take an NSAID

Nonsteroidal anti-inflammatory drugs such as ibuprofen, aspirin, or naproxen are your best choices. Do not exceed the recommended daily dosage or take them for more than a couple of days at a time. 

 

8. Make sure you’re hydrated 

Drink water or isotonic drinks to keep your hydration and electrolytes at an adequate level. Men require 13 cups (3 liters) of water per day, while women need nine (2.2 liters). 

 

9. Stretch 

Stretching your muscles when you wake up can prevent muscles from stiffening. It increases blood flow throughout your body, and prepares the muscles for the daily movements ahead.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  

https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    

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https://GSiyers home remedies.blogspot.com   is the latest addition to my blogs