Endometriosis ups risk of miscarriage in women

Mothers-to-be, please take note! Women with endometriosis - the lining of the uterus (womb) grows outside of the uterus - are at a greater risk of complications during pregnancy and at delivery, a recent study has warned.

The results revealed that the women with this condition were at a higher risk of preterm birth, miscarriage, cesarean delivery and placenta previa.

Researchers showed that endometriosis was associated with the birth of infants who were small for their gestational age.

Researcher  said that it is important that women with a history of endometriosis and obstetricians caring for them, are aware of this association between prior endometriosis and higher risks of miscarriage, preterm birth, placenta previa, cesarean delivery and a baby small for gestational age.

Dr. added that these pregnancies deserve closer monitoring for these complications.

"Endometriosis is known to alter a woman's physiology in a way that could interfere with a number of stages of pregnancy," stated the Dr.

From causing inflammation at the endometrium, to resisting the action of progesterone during implantation and throughout the pregnancy, there are a number of ways that endometriosis may affect the normal course of pregnancy, the researchers explained.

The team analysed 24 studies, which comprised over a million women.

"Studies like ours help clarify the findings by pooling the data from many studies to give the field a more conclusive answer to a debated research question. The collective data is stronger than any single study alone and often helps shape opinion in the field."

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Vaginal progesterone treatment may help pregnant women cut preterm birth risk

Treatment with vaginal progesterone in women with a short cervix and a twin pregnancy may reduce the risk of preterm birth, claims a new study.

The results indicated, women who received vaginal progesterone were 31% less likely to deliver before 33 weeks of pregnancy.
The findings come from an Ultrasound in Obstetrics and Gynecology meta-analysis of six studies encompassing 303 women pregnant with twins, all of whom had a cervical length of 25 mm or less in the mid-trimester.

About 159 women received vaginal progesterone and 144 received a placebo or no treatment.

Vaginal progesterone also reduced the rate of preterm delivery before 32 weeks and 34 weeks.

Infants born to patients who received vaginal progesterone had a 30% reduction in the rate of respiratory distress syndrome, the most common complication of prematurity, a 46% reduction in the rate of mechanical ventilation and a 4% reduction in the risk of dying in the neonatal period.

“To date, clinical practice and national recommendations to prevent preterm birth and reduce related adverse outcome in twin pregnancies vary significantly because of a lack of convincing scientific evidence and regional variation in the interpretation of said evidence,” said Basky Thilaganathan, Ultrasound in Obstetrics and Gynecology’s chief.

“The findings of this individual patient data meta-analysis provide scientific evidence that treatment with vaginal progesterone in women with a short cervix and a twin pregnancy reduces the frequency of preterm birth and related serious adverse perinatal outcomes,” Thilaganathan added.

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