Monday, December 01, 2025

Your Poop Schedule Says a Lot About Your Overall Health, Study Shows

"How often do you poop?" might sound like a very personal question, but your answer could reveal quite a lot about your overall health.

A study published in July 2024 investigated how often 1,425 people went number two, and compared those stats to their demographic, genetic, and health data.

The healthiest participants reported pooping once or twice a day – a 'Goldilocks zone' of bowel movement frequency.

Pooping too often or too rarely were both associated with different underlying health issues, the team led by researchers at the Institute for Systems Biology (ISB) found.

"This study shows how bowel movement frequency can influence all body systems, and how aberrant bowel movement frequency may be an important risk factor in the development of chronic diseases," says ISB microbiologist Sean Gibbons, the corresponding author of the report.

"These insights could inform strategies for managing bowel movement frequency, even in healthy populations, to optimize health and wellness."

The study investigated the bathroom habits of people who were "generally healthy" – that is, with no history of kidney or gut issues like kidney disease, irritable bowel syndrome, or Crohn's disease

 Participants self-reported how often they dropped the kids off at the pool, and the researchers organized them into four categories: constipation for those reporting one or two bowel movements per week; low-normal for three to six movements per week; high-normal for one to three movements per day; and diarrhea for four or more watery stools per day.

The researchers also analyzed patients' blood metabolites and chemistry, their genetics, and the gut microbes present in their stool samples.

The team looked for possible associations between bowel movement frequency and these health markers, as well as other factors like their age and sex.

In general, those who reported less frequent bowel movements tended to be women, younger, and with a lower body mass index (BMI). But even accounting for these factors, people with constipation or diarrhea showed clear links to underlying health issues.

Bacteria usually found in the upper gastrointestinal tract were more common in stool samples from participants with diarrhea. Their blood samples, meanwhile, showed biomarkers associated with liver damage.

Stool samples from people with less frequent bowel movements had higher levels of bacteria associated with protein fermentation. This is a known hazard from constipation

"If stool sticks around too long in the gut, microbes use up all of the available dietary fiber, which they ferment into beneficial short-chain fatty acids," says Johannes Johnson-Martinez, a bioengineer at ISB.

"After that, the ecosystem switches to fermentation of proteins, which produces several toxins that can make their way into the bloodstream."

Sure enough, some of these byproducts were found in these patients' blood samples. Particularly enriched was a metabolite called indoxyl-sulfate, a known product of protein fermentation that can damage the kidneys.

The team suggests the finding is potential evidence of a causal link between bowel movement frequency and overall health.

There is some hope that people can change their habits and, as a result, their health. Recent research suggests your gut microbiome can shift a lot faster than you might think.

For instance, a 2025 study from Germany, yet to undergo peer review, tracked inactive adults who began resistance training twice or three times a week. Those who gained the most strength showed changes in the makeup of their gut bacteria in just eight weeks.

These kinds of changes might help some people move out of the constipation or diarrhea categories and into a healthier bowel-movement range.

Those in the Goldilocks zone of pooping reported eating more fiber, drinking more water, and exercising more often. Their stool samples also showed high levels of bacteria associated with fermenting fiber.

 A clinical trial published in 2025 by US researchers found that people with a lot of methane-producing microbes in their guts are especially efficient at turning dietary fiber into short-chain fatty acids.

This suggests that both the amount of fiber and the specific mix of microbes in an individual's gut are important, which explains why two people eating the same diet can experience different health outcomes.

Of course, everybody's found themselves at one extreme or the other at some point in their lives, after catching a stomach bug or eating too much cheese. But this study was looking at people's everyday routine, and reveals how our own version of 'normal' could hint at health issues we weren't aware of.

The research was published in the journal Cell Reports Medicine.

An earlier version of this article was published in July 2025.

 

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

 

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Sunday, December 19, 2021

A targeted therapy to treat inflammatory bowel disease

The biomedical scientists of the University of California, Riverside have found a way for drugs to be more effective against inflammatory bowel disease/ IBD.

IBD, a chronic inflammatory disease of the intestine, includes Crohn’s disease and ulcerative colitis. It is commonly treated with one of several available biological drugs that block an inflammatory molecule called Tumour Necrosis Factor Alpha or TNF-alpha, from binding to two receptors, TNFR1 and TNFR2. Only about 50 % of patients are helped long term by this treatment.

TNF-alpha does drive much of the inflammation and tissue destruction in IBD, said a distinguished Prof., who led the study.

It’s why it is targeted by drugs. Our interest in this study was to look for a more targeted therapy that might have better impact than the existing approach, which is to block all TNF-alpha, he added.

The Prof. explained that people have 2 different receptors, TNFR1 & TNFR2, in each of their cells that bind TNF-alpha. Currently, TNF-alpha-targeted drugs block both TNFR1 & TNFR2. His experiments were done in mice, which have the same 2 receptors. The pattern of inflammation in mice is similar to that seen in humans.

TNF-alpha, produced by the body’s cells, also induced specialized immune and other cells, which both promote inflammation and suppressed it. Thus, TNF-alpha played a role in the destruction and the healing of tissues—a double-edged sword. He said evidence existed that TNFR1 may be driving most of the destructive effects of IBD, and whereas TNFR2 may drive the healing and restorative effects.

If you block both the receptors, you block the destructive effects and the recovery, he said.

To circumvent this, in our work we opted to do selective targeting of TNFR1, he explained.

His group was encouraged by 2 pieces of evidence suggesting that targeting TNFR1 maybe a more beneficial strategy, the researchers used a reagent from Inmune Bio, a biotechnology company that was selective for blocking TNFR1. Mice treated with this reagent were found to benefit from it. The researchers also did genetic targeting of TNFR1 to reduce its signaling. The impact, they found, was dramatic.

When we reduced TNFR1 signalling, the mice showed a significant benefit relative to mice who had the full level of TNFR1 signalling, the Prof. said.

This approach may offer more opportunity to TNFR2 to contribute to the healing, he added.

According to the Prof., mice that have a genetic deficiency in TNFR2 got much more severe disease, suggesting that TNFR2 does indeed have beneficial effects.

Without TNFR2, IBD is a lot worse, he said.

Several diseases, such as rheumatoid arthritis, multiple sclerosis, and psoriasis, are related to the action of TNF-alpha, indeed, different tissues in the body are differently sensitive to the effects of TNF-alpha. The role of the receptors TNFR1 and TNFR2 varied in the different tissues.

TNF-alpha is a very common way in which your body reacts to inflammatory triggers, such as infection, he said.

This protein can mediate several processes in the body to promote inflammation. The inflammation arises to clear an infection or kill a tumour. But in autoimmune diseases, the same inflammation and tissue damage that TNF-alpha provokes are what drive the disease. In other words, you want TNF-alpha at the right time to knock off a certain infection but once that is accomplished, you don’t want this protein to be around any longer. Many diseases are linked to TNF-alpha lingering in tissues, he added.

The prof. said the current research was a combination of testing approved drugs that are used in the clinic as well as examining more detailed questions related to the mechanisms of disease and protection.

It’s about continuously finding better cutting-edge drugs and better targets to treat disease, he said.


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

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