High blood-sugar makes Alzheimer's more deadly

A new study has revealed that high blood-sugar levels, such as those linked with Type 2 

diabetes, make beta amyloid protein associated with Alzheimer's disease dramatically 

more toxic to cells lining blood vessels in the brain.

The  study supports growing evidence pointing to glucose levels and vascular damage as 

contributors to dementia.

"Previously, it was believed that Alzheimer's disease was due to the accumulation of 

'tangles' in neurons in the brain from overproduction and reduced removal of beta amyloid 

protein," senior investigator said.

"While neuronal involvement is a major factor in Alzheimer's development, recent 

evidence indicates damaged cerebral blood vessels compromised by high blood sugar 

play a role. Even though the links among Type 2 diabetes, brain blood vessels and 

Alzheimer's progression are unclear, hyperglycemia appears to play a role," he said.

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