Cutting down sugar could reduce cancer risk in obese and diabetic people

Blocking dietary sugar and its activity in tumour cells may reduce cancer risk and progression in obese and diabetic people , a new study has found.

The study, by researchers , conducted in fruit flies, provides insight as to why metabolism-related diseases such as diabetes or obesity are associated with certain types of cancer, including pancreatic, breast, liver, and colon cancers.

A researcher has developed a cancer model in the fruit fly Drosophila that allows scientists to evaluate diseases in the context of the whole animal and multiple genetic targets, rather than just looking at the connection of one gene to one disease.

In the current study, he used fruit flies to understand the effects of diet and insulin resistance on cancer progression.

Cells use glucose for energy and to grow. When a cell becomes insulin resistant, glucose builds up in the blood instead of being absorbed by the cell, starving the cell and leading to metabolic diseases like diabetes.

Because of this dysfunctional growth, scientists have been puzzled about how tumours can thrive in an insulin-resistant environment.

"Previous research has established a strong correlation between metabolic diseases and pancreatic, breast, liver, and colon cancers, but we have not determined how tumours grow so aggressively in this environment if they do not have the energy provided by glucose," Dr. said.

"Using our fruit fly model, we discovered how tumours overcome insulin resistance in the body and turn metabolic dysfunction to their advantage," the researcher added.

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