Women more susceptible than men to asthma
Women are twice as likely as men to have asthma, and this gender difference may be caused by the effects of sex hormones on lung cells, a study has found.
Researchers found that testosterone hindered an immune cell linked to asthma symptoms, such as inflammation and mucus production in the lungs.
"When we started this study, we really thought that ovarian hormones would increase inflammation, more so than testosterone making it better," said a researcher.
"I was surprised to see that testosterone was more important in reducing inflammation," said a senior author of the study.
Prior studies have found that, before puberty, boys have about 1.5 times higher rate of asthma than girls. That trend reverses after puberty, when women are twice likely to have asthma as men, researchers said.
This pattern continues until women hit menopause, and then the asthma rates in women start to decline.
Increased asthma symptoms are regulated by many different factors, including exposure to allergens and viral infections, and the researchers suspected that sex hormones might also be involved.
Researchers looked at human and mouse cells to further study the trend in gender differences that they had observed.
They focused on lung cells called Group 2 innate lymphoid cells, or ILC2 cells. These cells make cytokines, proteins that cause inflammation and mucus production in the lungs, which makes it harder to breathe.
The researchers collected blood from people with and without asthma and found that those with asthma had more ILC2 cells than those without. Of that group, asthmatic women had more ILC2 cells than asthmatic men.
ILC2 cells are also found in the lungs of mice, but they are rare. They make up only about 10,000 of the 10 million cells in a mouse lung, researchers said.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
Researchers found that testosterone hindered an immune cell linked to asthma symptoms, such as inflammation and mucus production in the lungs.
"When we started this study, we really thought that ovarian hormones would increase inflammation, more so than testosterone making it better," said a researcher.
"I was surprised to see that testosterone was more important in reducing inflammation," said a senior author of the study.
Prior studies have found that, before puberty, boys have about 1.5 times higher rate of asthma than girls. That trend reverses after puberty, when women are twice likely to have asthma as men, researchers said.
This pattern continues until women hit menopause, and then the asthma rates in women start to decline.
Increased asthma symptoms are regulated by many different factors, including exposure to allergens and viral infections, and the researchers suspected that sex hormones might also be involved.
Researchers looked at human and mouse cells to further study the trend in gender differences that they had observed.
They focused on lung cells called Group 2 innate lymphoid cells, or ILC2 cells. These cells make cytokines, proteins that cause inflammation and mucus production in the lungs, which makes it harder to breathe.
The researchers collected blood from people with and without asthma and found that those with asthma had more ILC2 cells than those without. Of that group, asthmatic women had more ILC2 cells than asthmatic men.
ILC2 cells are also found in the lungs of mice, but they are rare. They make up only about 10,000 of the 10 million cells in a mouse lung, researchers said.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
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Women
are twice as likely as men to have asthma, and this gender difference
may be caused by the effects of sex hormones on lung cells, a study has
found.
Researchers found that testosterone hindered an immune cell linked to asthma symptoms, such as inflammation and mucus production in the lungs.
Researchers found that testosterone hindered an immune cell linked to asthma symptoms, such as inflammation and mucus production in the lungs.
Women are twice as likely as men to have asthma, and this gender
difference may be caused by the effects of sex hormones on lung cells, a
study has found.
Researchers found that testosterone hindered an immune cell linked to asthma symptoms, such as inflammation and mucus production in the lungs.
"When we started this study, we really thought that ovarian hormones would increase inflammation, more so than testosterone making it better," said Dawn Newcomb, from the Vand ..
Researchers found that testosterone hindered an immune cell linked to asthma symptoms, such as inflammation and mucus production in the lungs.
"When we started this study, we really thought that ovarian hormones would increase inflammation, more so than testosterone making it better," said Dawn Newcomb, from the Vand ..
Labels: asthma, Breathing difficulties, cytokines, hinders, immune ells, inflammation, innate lymphoid cells(ILC2), lung cells, mucus, prone, sex hormones, testosterone, women
posted by G S Iyer at 8:01 AM
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