Dysfunction in single gene increases risk of diabetes

Researchers including an Indian-origin researcher have found that dysfunction in a single gene in mice causes fasting hyperglycemia, which is one of the major symptoms of type 2 diabetes.

Researchers including an Indian-origin researcher have 

found that dysfunction in a single gene in mice causes 

fasting hyperglycemia, which is one of the major symptoms 

of type 2 diabetes.

Lead author Bellur S. Prabhakar, professor and head of 

microbiology and immunology at UIC, said that if a gene 

called MADD is not functioning properly, insulin is not 

released into the bloodstream to regulate blood sugar levels.

Small genetic variations found among thousands of human 

subjects revealed that a mutation in MADD was strongly 

associated with type 2 diabetes in Europeans and Han 

Chinese.

To study the role of MADD in diabetes, Prabhakar and his 

team developed a mouse model in which the MADD gene 

was deleted from the insulin-producing beta cells. All such 

mice had elevated blood glucose levels, which the 

researchers found was due to insufficient release of insulin.

The finding shows that type 2 diabetes can be directly 

caused by the loss of a properly functioning MADD gene 

alone, Prabhakar said. “Without the gene, insulin can’t leave 

the beta cells, and blood glucose levels are chronically high.

The findings have been reported online in the journal 

Diabetes.

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