Why some people remain lean and others obese

Researchers have said that becoming obese or remaining lean can depend on the dynamics of the mitochondria, the body's energy-producing "battery."

Mitochondria are vital cellular organelles that generate and maintain proper energy levels in complex organisms. Using animal models, the  research team studied mitochondria in different populations of brain cells known to be involved in the regulation of appetite.

The team found that during the transition from a fasting to an over-fed state, mitochondria in neurons that promote hunger show dynamic changes that are the opposite of those found in neurons that control feelings of fullness.

Lead author  said that they have found that mitochondrion need to have ongoing dynamic plasticity in order to support neurons, which are necessary for appetite and for the maintenance of life.

He asserted that if these dynamic events - during which the mitochondria fuse to become more effective in generating energy - are disrupted, mitochondria become static, appetite-stimulating neurons become less active, and animals do not develop obesity when exposed to high-fat, high-calorie diets.

The co-lead author said these same cellular events have different consequences in neurons that promote feelings of fullness. 

The study showed that similar molecular drivers control mitochondria-endoplasmic reticulum interactions and related stress. If the cellular events are disrupted in these mitochondria, animals become morbidly obese.

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

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