What causes migraine?

Adults who suffer from migraine are more likely to have 

incomplete network of arteries supplying blood flow to the 

brain, a new study has revealed.

The research found that variations in arterial anatomy lead 

to asymmetries in cerebral blood flow that might contribute 

to the process triggering migraines.

The arterial supply of blood to the brain is protected by a 

series of connections between the major arteries, termed the 

"circle of Willis."

People with migraine, particularly migraine with aura, are 

more likely to be missing components of the circle of Willis.

Study's lead author, said that people with migraine actually 

have differences in the structure of their blood vessels - this 

is something you are born with.

"These differences seem to be associated with changes in 

blood flow in the brain, and it's possible that these changes 

may trigger migraine, which may explain why some people, 

for instance, notice that dehydration triggers their 

headaches," he said.

In a study of 170 people from three groups - a control group 

with no headaches, those who had migraine with aura, and 

those who had migraine without aura - the team found that 

an incomplete circle of Willis was more common in people 

with migraine with aura (73 percent) and migraine without 

aura (67 percent), compared to a headache-free control 

group (51 percent).

The team used magnetic resonance angiography to examine 

blood vessel structure and a non-invasive magnetic 

resonance imaging method , called Arterial 

spin labelling (ASL), to measure changes in cerebral blood 

flow.

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