'Artificial bones' generated from umbilical cord stem cells
Scientists have successfully developed 'artificial bones' from
umbilical cord stem cells, paving way for repair of bones
and replacement of lost cartilage in limbs. Scientists
in Spain, patented a new bio-material that facilitates
generating bone tissue or artificial bones. The material
consists of an activated carbon cloth support for cells that
differentiate giving rise to a product that can promote bone
growth.
Although the method has not yet been applied in living
organisms, laboratory results are highly promising. In the
future, they could help manufacture medicines for the
repair of bone or osteochondrial, tumour or traumatic
lesions and to replace lost cartilage in limbs, researchers
said.
After obtaining artificial bones in the laboratory, the
researchers' next step is to implant this bio-material in
experimental animal models like rats or rabbits to see if it
can regenerate bone in them.
The scientists have made this important scientific
breakthrough after years of research in cell biology, radio-
biology and materials studies. No alternative materials are
currently available on the market, nor have any been
described in the literature, researchers said.
Precedents exist in the development of materials that fulfil
the basic function of stimulating cell differentiation but a
biologically complex material similar to bone tissue has
never before been produced "ex vivo".
The method of stem cell differentiation uses a three-
dimensional support and facilitates obtaining cell types
implicated in bone regeneration in cell culture conditions
not requiring additional differentiation factors or factors
that differ from those present in the cell culture serum.
Thanks to this invention, a bio-material consisting of stem
cells supported on activated carbon cloth and capable of
generating a product in which osteochondrial and
mineralised extracellular organic matrix lineage cells exist,
can be obtained, researchers said. The patent developed in
Granada could have numerous applications in stem cell use
in regenerative medicine, as well as in treating bone tissue
and cartilage lesion problems.
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Labels: activated, artificial bones, carbon, cartilage, generation, lesion, osteochondrial, replacement, Stem cells, tissues, trauma, tumour, umbilical cord
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