Thursday, July 25, 2013

'Artificial bones' generated from umbilical cord stem cells

Scientists have successfully developed 'artificial bones' from 

umbilical cord stem cells, paving way for repair of bones 

and replacement of lost cartilage in limbs. Scientists 

in  Spain, patented a new bio-material that facilitates 

generating bone tissue or artificial bones. The material 

consists of an activated carbon cloth support for cells that 

differentiate giving rise to a product that can promote bone 

growth.

Although the method has not yet been applied in living 

organisms, laboratory results are highly promising. In the 

future, they could help manufacture medicines for the 

repair of bone or osteochondrial, tumour or traumatic 

lesions and to replace lost cartilage in limbs, researchers 

said.


After obtaining artificial bones in the laboratory, the 

researchers' next step is to implant this bio-material in 

experimental animal models like rats or rabbits to see if it 

can regenerate bone in them.


The scientists have made this important scientific 

breakthrough after years of research in cell biology, radio-

biology and materials studies. No alternative materials are 

currently available on the market, nor have any been 

described in the literature, researchers said.

Precedents exist in the development of materials that fulfil 

the basic function of stimulating cell differentiation but a 

biologically complex material similar to bone tissue has 

never before been produced "ex vivo".

The method of stem cell differentiation uses a three-

dimensional support and facilitates obtaining cell types 

implicated in bone regeneration in cell culture conditions 

not requiring additional differentiation factors or factors 

that differ from those present in the cell culture serum.

Thanks to this invention, a bio-material consisting of stem 

cells supported on activated carbon cloth and capable of 

generating a product in which osteochondrial and 

mineralised extracellular organic matrix lineage cells exist, 

can be obtained, researchers said. The patent developed in 

Granada could have numerous applications in stem cell use 

in regenerative medicine, as well as in treating bone tissue 

and cartilage lesion problems.


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