Abdominal CT by AI algorithm may help analyse abdominal fat, predict CVD risk
According to a recent presentation at the RSNA 2010 virtual meeting, Body composition metrics automatically calculated from abdominal CT exams by an artificial intelligence (AI) algorithm are significantly associated with patient risk for future major cardiovascular events that include heart attack and stroke.
Automated deep learning analysis of abdominal CT images produces a more precise measurement of body composition and predicts major cardiovascular events, such as heart attack and stroke,, better than overall weight or body mass index (BMI).
Unlike BMI, which is based on height and weight, a single axial CT slice of the abdomen visualizes the volume of subcutaneous fat area, visceral fat area and skeletal muscle area. However, manually measuring these individual areas is time intensive and costly.
“Established cardiovascular risk models rely on factors like weight and BMI that are crude surrogated of body composition,” said a researcher. “It’s well established that people with the same BMI can have markedly different proportions of muscle and fat. These differences are important for a variety of health outcomes”.
The study cohort was derived from 33, 182 abdominal CT outpatient exams performed on 23,136 patients in 2012. The researchers identified 12,128 patients who were free of major cardiovascular and cancer diagnoses at the time of imaging. Mean age of the patients was 52 years and 57% of patients were women.
The researchers selected the L3 CT slice from the 3rd lumbar spine vertebra) and calculated body composition areas for each patient. Patients were then divided into 4 quartiles based on the normalized values of subcutaneous fat area, visceral fat area and skeletal area.
In this retrospective study, it was determined which of these 12,1228 patients has a myocardial infarction ( heart attack) or stroke within 5 years after their index abdominal CT scan. The researchers found 1,560 myocardial infarctions and 938 strokes occurred in this study group.
Statistical analysis demonstrated that visceral fat area was independently associated with future heart attack and stroke. BMI was not associated with heart attack or stroke.
“The group of patients with the highest proportion of visceral fat area were more likely to have a heart attack, even when adjusted for known cardiovascular risk factors”, said a Dr. “ The group of patients with the lowest amount of visceral fat area were protected against stroke in the years following the abdominal CT exam”.
“ These results demonstrate that precise measures of body muscle and fat compartments achieved through CT outperform traditional biomarkers for predicting risk for cardiovascular outcomes”, the Dr. added.
According to the Dr., this work demonstrates that fully automated and normalized body composition analysis could not be applied to large-scale research projects.
This work shows the promise of AI systems to add value to clinical care by extracting new information from existing imaging data”, said the Dr. “The deployment of AI systems would allow radiologists, cardiologists and primary care doctors to provide better care to patients at minimal incremental cost to the health care system”.