Dim Light Escalates Breast Cancer's Spread to Bones
Exposure to dim light at night may contribute to the spreading of breast
cancer to bones, researchers have shown in an animal study.
When breast cancer spreads it often affects bones, cause severe pain and make them fragile. "To date no one has reported that exposure to dim light at night induces circadian disruption, which increases spread of bone metastatic breast cancer," said an Assistant Professor.
For the preliminary study, the team created a mouse model of bone metastatic breast cancer. They injected oestrogen receptor-positive human breast cancer cells, which have a low propensity to grow in bones, into the tibia (shinbone) of female mice.
Like humans, mice produced a strong night-time circadian melatonin signal, shown to produce strong anti-cancer actions and for promoting sleep.
While one group of mice was kept in the light for 12 hours each day, the other group of three mice in the dark for 12 hours. Another group spent 12 hours in light, followed by 12 hours in dim light at night.
X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle, he noted.
"Our research identified the importance of an intact nocturnal circadian melatonin anti-cancer signal in suppressing bone-metastatic breast tumour growth," said the Asst. Prof.
When breast cancer spreads it often affects bones, cause severe pain and make them fragile. "To date no one has reported that exposure to dim light at night induces circadian disruption, which increases spread of bone metastatic breast cancer," said an Assistant Professor.
For the preliminary study, the team created a mouse model of bone metastatic breast cancer. They injected oestrogen receptor-positive human breast cancer cells, which have a low propensity to grow in bones, into the tibia (shinbone) of female mice.
Like humans, mice produced a strong night-time circadian melatonin signal, shown to produce strong anti-cancer actions and for promoting sleep.
While one group of mice was kept in the light for 12 hours each day, the other group of three mice in the dark for 12 hours. Another group spent 12 hours in light, followed by 12 hours in dim light at night.
X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle, he noted.
"Our research identified the importance of an intact nocturnal circadian melatonin anti-cancer signal in suppressing bone-metastatic breast tumour growth," said the Asst. Prof.
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Labels: breast cancer spreading to bones, circadian rhythm, dim light, exposure, fragile, increases risk, metastatic, night, oestrogen receptor positive breast cancer cells, severe pain, tibia
posted by G S Iyer at 8:35 AM
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