Novel drug may help tackle treatment-resistant cancers
A new class of drug that has the potential to help cancer patients,
especially those suffering from breast cancer and who no longer respond
to existing therapies has been discovered.
Breast cancer patients frequently become resistant to existing treatments, leading to the disease becoming fatal.
Early lab-based tests of a drug named ICEC0942 were successful in targeting resistant breast cancers and indicated minimal side effects.
“Treatment-resistant tumours represent a significant threat for patients, as once a cancer stops responding to treatments there is increasingly little clinicians can do,” said a Professor.
“Drugs such as these could help to shift the balance back in favour of the patients, potentially providing a new option to patients for who existing treatments no longer work,” the Prof. added.
The findings, published in the journal, noted that the drug targets an enzyme called CDK7 — involved in directing cells through their life-cycle, which consists of growth, DNA replication and cell division.
CDK7 is also involved in the process of transcription — a vital step in gene expression — the creation of proteins to carry out cell functions.
Particular cancers, such as treatment-resistant breast cancers, have a unique dependence on transcription, meaning targeting CDK7 may be particularly effective.
By inhibiting transcription, ICEC0942 shuts down the ability of the cancer to spread.
In addition, cancers such as acute myeloid leukaemia and small-cell lung cancer are particularly transcription-dependent.
Therefore, ICEC0942 drug may also work well for these too, especially where they have become resistant to other treatments, the researchers suggested.
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Breast cancer patients frequently become resistant to existing treatments, leading to the disease becoming fatal.
Early lab-based tests of a drug named ICEC0942 were successful in targeting resistant breast cancers and indicated minimal side effects.
“Treatment-resistant tumours represent a significant threat for patients, as once a cancer stops responding to treatments there is increasingly little clinicians can do,” said a Professor.
“Drugs such as these could help to shift the balance back in favour of the patients, potentially providing a new option to patients for who existing treatments no longer work,” the Prof. added.
The findings, published in the journal, noted that the drug targets an enzyme called CDK7 — involved in directing cells through their life-cycle, which consists of growth, DNA replication and cell division.
CDK7 is also involved in the process of transcription — a vital step in gene expression — the creation of proteins to carry out cell functions.
Particular cancers, such as treatment-resistant breast cancers, have a unique dependence on transcription, meaning targeting CDK7 may be particularly effective.
By inhibiting transcription, ICEC0942 shuts down the ability of the cancer to spread.
In addition, cancers such as acute myeloid leukaemia and small-cell lung cancer are particularly transcription-dependent.
Therefore, ICEC0942 drug may also work well for these too, especially where they have become resistant to other treatments, the researchers suggested.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES. PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG- https://gseasyrecipes.blogspot.com/
FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG- https:// kneereplacement-stickclub.blogspot.com/
FOR CROCHET DESIGNS https://my crochet creations.blogspot.com/
Labels: Breast cancer, cell division, DNA, enzyme-CDK7, less side-effects, myeloid leukemia, novel drug- ICEC0942, replication, small cell lung cancer, tackles, targets, treatment-resistant cancers
posted by G S Iyer at 3:18 AM
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