A doctor discovers way to prevent Sepsis in Newborns
In a major breakthrough, a doctor has discovered an inexpensive prevention technique against sepsis. He along with members of his team has found that feeding babies with probiotic bacteria dramatically reduces the risk of sepsis in newborns. This is a breakthrough study in which it has been found that it is going to be an inexpensive treatment that could possibly save hundreds of thousands of newborns from a top killer- Sepsis .
Sepsis in early infancy results in one million annual deaths worldwide, most of them in developing countries. No efficient means of prevention is currently available. “All the sudden the baby stops being active. It stops crying and breastfeeding,” says the Dr. , a pediatrician , who led the study.”By the time the mother has a chance to bring the baby to the hospital, the baby dies,” he says.
Dr. who has been working on a way to prevent sepsis for the past 20 years ,early on thought probiotic bacteria might be the answer because they work well on another infection that affects preemies, called necrotizing enterocolitis which damages the intestines.The tricky part, Dr. says, was figuring out the best strain of bacteria to protect against sepsis.”We screened more than 280 strains in preliminary animal and human studies,” Dr. says. “So it was a very methodical process.”
In the end, the one that seemed the most promising was a strain of Lactobacillus plantarum isolated from the diaper of a healthy baby. So the Dr. and his team decided to move forward with a large-scale study on thousands of babies in rural places.
In a randomized, double-blind, placebo-controlled trial of an oral synbiotic preparation (Lactobacillus plantarum plus fructooligosaccharide) in rural places newborns, 4,556 infants that were at least 2,000 g at birth, at least 35 weeks of gestation, and with no signs of sepsis or other morbidity were enrolled and monitored for 60 days. There was a significant reduction in the primary outcome (combination of sepsis and death) in the treatment arm (risk ratio 0.60, 95% confidence interval 0.48–0.74), with few deaths (4 placebo, 6 synbiotic). Significant reductions were also observed for culture-positive and culture-negative sepsis and lower respiratory tract infections. These findings suggest that a large proportion of neonatal sepsis in developing countries could be effectively prevented using a synbiotic containing L. plantarum ATCC-202195.
The team of doctors was taken aback to see the results as the babies who were fed on the microbes for a week along with some sugars showed a dramatic reduction in their risk of death and sepsis by 40 percent, from 9 percent to 5.4 percent.The probiotics were highly effective against several other types of infections, including respiratory infections which dropped by about 30 percent after its administration .
“That was a big surprise, because we didn’t think gut bacteria were going to work in a distant organ like the lung,” Dr. says.The treatment worked so well that the safety board for trial stopped the study early. “We were planning to enroll 8,000 babies, but stopped at just over 4,000 infants,” Dr. says.
The only significant side effect seen in the study was abdominal distension, which occurred in six babies. But there were more cases reported in the placebo group than in the group that got the probiotic.
Dr. estimates a course of the probiotic costs about $1 per baby. “It can be manufactured in a very simple setting,” he says, “which makes it cheap.” It seems counter-intuitive as researcher are preventing a bacterial infection, Sepsis with bacteria.
How is that possible? “Essentially these bacteria have a whole number of health benefits that we have just started to understand in the past couple of years, says a neonatologist.
First off, these beneficial bacteria can push out harmful bacteria in the baby’s gut by changing the environment or simply using up resources, Dr. says.
The probiotic bacteria also produces a compound that strengthens the wall of the intestine. “It acts as a barrier to prevent the bad bacteria from going through the wall into the blood,” he says.
And, the probiotic bacteria can jump-start a baby’s immune system.
“They can promote maturation of the immune system in a healthier way,” Dr. says. “Probiotics can be much more powerful than drugs.”
But like drugs, they need to be fully tested before they become routine in maternity wards around the world, Dr. says. That means testing the probiotic in more locations and on babies who have the highest risk for sepsis — those born prematurely or underweight.
“Sepsis is such a important problem around the world,” Dr. says. “This study has huge potential,” according to some reports .
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on. https://gscrochetdesigns.blogspot.com. one can see my crochet creations https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
Sepsis in early infancy results in one million annual deaths worldwide, most of them in developing countries. No efficient means of prevention is currently available. “All the sudden the baby stops being active. It stops crying and breastfeeding,” says the Dr. , a pediatrician , who led the study.”By the time the mother has a chance to bring the baby to the hospital, the baby dies,” he says.
Dr. who has been working on a way to prevent sepsis for the past 20 years ,early on thought probiotic bacteria might be the answer because they work well on another infection that affects preemies, called necrotizing enterocolitis which damages the intestines.The tricky part, Dr. says, was figuring out the best strain of bacteria to protect against sepsis.”We screened more than 280 strains in preliminary animal and human studies,” Dr. says. “So it was a very methodical process.”
In the end, the one that seemed the most promising was a strain of Lactobacillus plantarum isolated from the diaper of a healthy baby. So the Dr. and his team decided to move forward with a large-scale study on thousands of babies in rural places.
In a randomized, double-blind, placebo-controlled trial of an oral synbiotic preparation (Lactobacillus plantarum plus fructooligosaccharide) in rural places newborns, 4,556 infants that were at least 2,000 g at birth, at least 35 weeks of gestation, and with no signs of sepsis or other morbidity were enrolled and monitored for 60 days. There was a significant reduction in the primary outcome (combination of sepsis and death) in the treatment arm (risk ratio 0.60, 95% confidence interval 0.48–0.74), with few deaths (4 placebo, 6 synbiotic). Significant reductions were also observed for culture-positive and culture-negative sepsis and lower respiratory tract infections. These findings suggest that a large proportion of neonatal sepsis in developing countries could be effectively prevented using a synbiotic containing L. plantarum ATCC-202195.
The team of doctors was taken aback to see the results as the babies who were fed on the microbes for a week along with some sugars showed a dramatic reduction in their risk of death and sepsis by 40 percent, from 9 percent to 5.4 percent.The probiotics were highly effective against several other types of infections, including respiratory infections which dropped by about 30 percent after its administration .
“That was a big surprise, because we didn’t think gut bacteria were going to work in a distant organ like the lung,” Dr. says.The treatment worked so well that the safety board for trial stopped the study early. “We were planning to enroll 8,000 babies, but stopped at just over 4,000 infants,” Dr. says.
The only significant side effect seen in the study was abdominal distension, which occurred in six babies. But there were more cases reported in the placebo group than in the group that got the probiotic.
Dr. estimates a course of the probiotic costs about $1 per baby. “It can be manufactured in a very simple setting,” he says, “which makes it cheap.” It seems counter-intuitive as researcher are preventing a bacterial infection, Sepsis with bacteria.
How is that possible? “Essentially these bacteria have a whole number of health benefits that we have just started to understand in the past couple of years, says a neonatologist.
First off, these beneficial bacteria can push out harmful bacteria in the baby’s gut by changing the environment or simply using up resources, Dr. says.
The probiotic bacteria also produces a compound that strengthens the wall of the intestine. “It acts as a barrier to prevent the bad bacteria from going through the wall into the blood,” he says.
And, the probiotic bacteria can jump-start a baby’s immune system.
“They can promote maturation of the immune system in a healthier way,” Dr. says. “Probiotics can be much more powerful than drugs.”
But like drugs, they need to be fully tested before they become routine in maternity wards around the world, Dr. says. That means testing the probiotic in more locations and on babies who have the highest risk for sepsis — those born prematurely or underweight.
“Sepsis is such a important problem around the world,” Dr. says. “This study has huge potential,” according to some reports .
this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on. https://gscrochetdesigns.blogspot.com. one can see my crochet creations https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
In a major
breakthrough, Dr. Pinaki Panigrahi, a US-based Odia doctor has
discovered an inexpensive prevention technique against sepsis. He along
with members of his team has found that feeding babies with probiotic
bacteria dramatically reduces the risk of sepsis in newborns. This is a
breakthrough study in which it has been found that it is going to be
an inexpensive treatment that could possibly save hundreds of thousands
of newborns from a top killer- Sepsis .
Sepsis in early infancy ...
Read more at Medical Dialogues: Breakthrough: US Based Indian doctor discovers way to prevent Sepsis in Newborns http://medicaldialogues.in/breakthrough-us-based-indian-doctor-finds-way-to-prevent-sepsis-in-newborns/
Copyright 2017@ Medical Dialogues
Read more at Medical Dialogues: Breakthrough: US Based Indian doctor discovers way to prevent Sepsis in Newborns http://medicaldialogues.in/breakthrough-us-based-indian-doctor-finds-way-to-prevent-sepsis-in-newborns/
Copyright 2017@ Medical Dialogues
Labels: inexpensive, newborn, prevent, probiotic bacteria, Respiratory infections, sepsis
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