Low Testosterone sign of PCa reclassification: Study

A new research has found that men under active surveillance for prostate cancer who have reductions in testosterone levels are more at risk of facing the disease.

The findings of the study were published online on May 4 in BJU International.

Ignacio F. San Francisco, M.D., of the Pontificia Universidad Catolica de Chile, Santiago, and colleagues analyzed data of 154 men who were on active surveillance for prostate cancer in order to assess the association between testosterone levels and risk of disease reclassification.

The study showed that patients who had disease that was reclassified, compared with those who did not, had lower levels of free testosterone (0.75 versus 1.02 ng/dL; P = 0.03).

A higher rate of reclassification of disease was observed in patients with free testosterone levels <0 .45="" 0.032="" br="" dl="" in="" levels="" ng="" than="" those="" with="">
Patients with free testosterone levels <0 .45="" 1.25="" 14.73="" 4.3="" 95="" at="" br="" confidence="" disease="" dl="" increased="" interval="" ng="" odds="" of="" percent="" ratio="" reclassification="" risk="" to="" were="">
"Men with moderately severe reductions in free testosterone level are at increased risk of disease reclassification," the researchers claimed.

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