Exposure to solvents before first childbirth linked to higher breast cancer risk

For the research, Dr. Ekenga and her coworkers analyzed data from the Sister Study. This took into account 50,884 women who were not diagnosed with cancer at the onset of the study, but they were sisters of women who had been diagnosed with breast cancer.

The lead researcher Christine C. Ekenga, PhD, a postdoctoral fellow in the epidemiology branch of the National Institute of Environmental Health Sciences at the National Institutes of Health said in a statement, "Our study is an important first step toward understanding how the timing of chemical exposures may impact breast cancer risk. We hope that our findings will generate additional interest in the possible role of solvents and other chemicals in the etiology of breast cancer."

The research was conducted on the data spanning the years from 2003-2009, where in the participants were required to answer questionnaires with respect to their employment history as well as other possible risk factors for breast cancer. The participants were also followed up for health updates on an yearly basis.

The Questions pertained to the duration of solvent exposure in their job, the weekly occurrence of this exposure and how old they were when they took up their first job involving organic solvents.

During the course of the study, 1,798 women were diagnosed with breast cancer. Of these women, 1,255 had invasive cancer, and 77 percent of these cancers were hormone-receptor positive.

In the words of the researcher, Christine C. Ekenga, "The time between puberty and before first birth is an important period of development when the breast may be more vulnerable to chemical exposures. We observed that women who started working with solvents before their first full-term birth had a greater risk for breast cancer. All women should be familiar with the chemicals and hazards that are present in their workplace, and use personal protective equipment and minimize exposures when appropriate."

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