Smokers with gene defect may get lung cancer

The BRCA mutations already greatly raise the risk of breast, ovarian and prostate cancers. Smoking causes several ailments, from heart disease to stroke, emphysema and cancer. But the chance of any individual smoker developing lung cancer is only 15 percent. The researchers then started the study with an aim to find if a genetic factor was involved in this.

The researchers were not looking for mutations in BRCA2. For the study, a genome-wide association study was conducted by the researchers, They looked at all the known genes and compared genetic data on more than 11,000 lung cancer patients and 15,000 people who did not have lung cancer.

The researchers found 50 potential mutations of interest, and then focused their study on some mutations in the BRCA2 gene. The researchers said that for a smoker carrying this variant, the risk of developing lung cancer is approximately doubled. The study suggests that cancer drugs called PARP inhibitors might help lung cancer patients with this mutation.

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