Tanning gene linked to high testicular cancer risk

A gene that is important in skin tanning has been linked to increased risk for testicular cancer in white men, according to a study.

Scientists found that almost 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study.

The team suspected that variations in a gene pathway controlled by the tumour suppressor gene p53 could have both positive and negative effects on human health.

The author on the paper and researcher , said that gene variations occur naturally, and may become common in a population if they convey a health benefit.

He asserted that it appears that this particular variant could help protect light-skinned individuals from UV skin damage, like burning or cancer, by promoting the tanning process, but it permits testicular stem cells to grow in the presence of DNA damage, when they are supposed to stop growing.

He explained that p53 stimulates skin tanning when ultraviolet light activates it in the skin. It then must bind a specific sequence of DNA located in a gene called the KIT ligand oncogene (KITLG), which stimulates melanocyte production, causing the skin to tan.

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